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Akademický článek

Combining a deep learning model with clinical data better predicts hepatocellular carcinoma behavior following surgery

Autor: Benoit Schmauch, Sarah S. Elsoukkary, Amika Moro, Roma Raj, Chase J. Wehrle, Kazunari Sasaki, Julien Calderaro, Patrick Sin-Chan, Federico Aucejo, Daniel E. Roberts

Publikováno v: Journal of Pathology Informatics, Vol 15, Iss , Pp 100360- (2024)

Hepatocellular carcinoma (HCC) is among the most common cancers worldwide, and tumor recurrence following liver resection or transplantation is one of the highest contributors to mortality in HCC patients after surgery. Using artificial intelligence

Externí odkaz: https://doaj.org/article/9df2723580f74a68805a47b36e4ecca2

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Akademický článek

Dynamique sédimentaire et taphonomie des abris-sous-roche et des porches de grotte en milieu périglaciaire

Autor: Pascal Bertran, Cédric Beauval, Stéphane Boulogne, Michel Brenet, Julia Chrzavzez, Émilie Claud, Sandrine Costamagno, Véronique Laroulandie, Arnaud Lenoble, Philippe Malaurent, Bertrand Masson, Jean-Baptiste Mallye, Patrick Sin, Céline Thiébaut, Luc Vallin

Publikováno v: Les Nouvelles de l’Archéologie, Vol 118, Pp 11-16 (2009)

The Gavarnie project allows documentation of the sedimentary dynamics and taphonomic processes of rockshelter and cave entrances in a modern periglacial environment in the central Pyrenees. Thermal records in a small cave show that the regime is sign

Externí odkaz: https://doaj.org/article/b7bcb2d0e1b74e43b4484f8dc744db30

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Rare genetic coding variants associated with human longevity and protection against age-related diseases

Publikováno v: Nature Aging. 1:783-794

Extreme longevity in humans has a strong genetic component, but whether this involves genetic variation in the same longevity pathways as found in model organisms is unclear. Using whole-exome sequences of a large cohort of Ashkenazi Jewish centenari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88639d6837851dd07cacaf6f9b0cb4be
https://doi.org/10.1038/s43587-021-00108-5

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Akademický článek

The airborne transmission of viruses causes tight transmission bottlenecks

Autor: Patrick Sinclair, Lei Zhao, Clive B. Beggs, Christopher J. R. Illingworth

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract The transmission bottleneck describes the number of viral particles that initiate an infection in a new host. Previous studies have used genome sequence data to suggest that transmission bottlenecks for influenza and SARS-CoV-2 involve few v

Externí odkaz: https://doaj.org/article/54dff7b242dc4b99aea5535ed74d21d9

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Application of deep learning models on whole slide images uncover new histological markers related to high-risk malignant pleural mesothelioma

Autor: Douglas Hartman, Jean-Eudes Le Douget, Ye Ye, Yaming Li, Patrick Sin-Chan, Elodie Pronier, Michael Becich

Publikováno v: Journal of Clinical Oncology. 40:e13580-e13580

e13580 Background: Malignant Pleural mesothelioma (MPM) is a highly aggressive cancer of the pleural surface and represents 80-90% of mesothelioma diagnosis. MPM is broadly subclassified into three histological subgroups (epithelioid, sarcomatoid, bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d571737da096c219249bef18045e128
https://doi.org/10.1200/jco.2022.40.16_suppl.e13580

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Autor: Joris Deelen, Claudia Gonzaga-Jauregui, Patrick Sin-Chan, Tina Gao, Nir Barzilai, Gil Atzmon, A. R. Shuldiner, Danielle Gutman, Gabriel Lidzbarsky, Sofiya Milman

Publikováno v: Aging Cell

Centenarians (exceptionally long‐lived individuals—ELLI) are a unique segment of the population, exhibiting long human lifespan and healthspan, despite generally practicing similar lifestyle habits as their peers. We tested disease‐associated m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f57c04ba6647f6174f7c13f9f88b2d
https://hdl.handle.net/21.11116/0000-000B-2D86-C

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Exome-wide association studies in general and long-lived populations identify genetic variants related to human age

SUMMARYAging is characterized by degeneration in cellular and organismal functions leading to increased disease susceptibility and death. Although our understanding of aging biology in model systems has increased dramatically, large-scale sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0b9122e0fec6a5f78b11396b9011569
https://doi.org/10.1101/2020.07.19.188789

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Tails of a Super Histone

Autor: Iqra Mumal, Patrick Sin-Chan, Annie Huang

Publikováno v: Cancer Cell. 35:7-9

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We generated genetically engineered inducible mice and showed that H3.3 K27M enha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccdd25339a761072e22d9b70f6d59f1
https://doi.org/10.1016/j.ccell.2018.12.005

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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Autor: Anne Song, Alexander J. Federation, Leo J.Y. Kim, David T.W. Jones, Ana Fernandez Miñan, Laura McDonald, Mathieu Lupien, Susan Q. Ke, Lukas Chavez, Briana C. Prager, Sheila K. Singh, Peter B. Dirks, Borja L. Holgado, Kristian W. Pajtler, Yan Li, Till Milde, Marc Zapatka, Angel M. Carcaboso, Livia Garzia, Xiuxing Wang, Chao Jun Li, Kenneth Aldape, Christine Lee, Ian C. Scott, Xin Wang, Laura K. Donovan, Xiu-Wu Bian, Sylvia Doan, Stephen M. Dombrowski, Betty Luu, Michael D. Taylor, Adam Tropper, Vaidehi Mahadev, James E. Bradner, Ryan C. Gimple, Tyler E. Miller, Serap Erkek, Christopher G. Hubert, Daniel C. Factor, Kulandaimanuvel Antony Michaelraj, Stefan M. Pfister, Kelsey C. Bertrand, Jennifer Zuccaro, Zhiqin Huang, Yuan Yao Thompson, Hendrik Witt, Nada Jabado, Konstantin Okonechnikov, Paul A. Northcott, James J. Morrow, Senthuran Vijayarajah, Jeremy N. Rich, Susanne Gröbner, Andrey Korshunov, Vijay Ramaswamy, Sisi Lai, Stephen C. Mack, Alina Saiakhova, Annie Huang, Claudia L.L. Valentim, James T. Rutka, Eric Bouffet, Xiaochong Wu, Matthias Lienhard, Qiulian Wu, Jüri Reimand, Peter J. Houghton, Andrew R. Morton, Peter C. Scacheri, John J.Y. Lee, Marina Ryzhova, Patrick Sin-Chan, Peter Lichter, Stephen T. Keir, Marcel Kool

Publikováno v: Nature
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many malignancies remain unknown or non-targetable, so alternative approaches to the identification of therapeutic leads are necessary. Ependymomas are ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14b43b01c6fec382bc89e653995fb58
https://doi.org/10.1038/nature25169

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