Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Patrick Simon Welz"'
Autor:
Paula Berbegal-Sáez, Ines Gallego-Landin, Javier Macía, Laia Alegre-Zurano, Adriana Castro-Zavala, Patrick-Simon Welz, Salvador A. Benitah, Olga Valverde
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
Maintaining proper circadian rhythms is essential for coordinating biological functions in mammals. This study investigates the effects of daily arrhythmicity using Bmal1-knockout (KO) mice as a model, aiming to understand behavioural and motivationa
Externí odkaz:
https://doaj.org/article/3137121a7c5c4c9195553cb0a32dc0f9
Autor:
Jacob G. Smith, Kevin B. Koronowski, Thomas Mortimer, Tomoki Sato, Carolina M. Greco, Paul Petrus, Amandine Verlande, Siwei Chen, Muntaha Samad, Ekaterina Deyneka, Lavina Mathur, Ronnie Blazev, Jeffrey Molendijk, Arun Kumar, Oleg Deryagin, Mireia Vaca-Dempere, Valentina Sica, Peng Liu, Valerio Orlando, Benjamin L. Parker, Pierre Baldi, Patrick-Simon Welz, Cholsoon Jang, Selma Masri, Salvador Aznar Benitah, Pura Muñoz-Cánoves, Paolo Sassone-Corsi
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112588- (2023)
Summary: Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested the interactions between clocks in
Externí odkaz:
https://doaj.org/article/da43be69311647c3a3d0a4fdfd5731ef
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100539- (2021)
Summary: Molecular daily rhythms can be captured by precisely timed tissue harvests from groups of animals. This protocol will allow the investigator to identify transcriptional rhythms in the mouse liver while also providing a template for similar a
Externí odkaz:
https://doaj.org/article/830a73ddd86d44f7b6644631f4b16ad5
Autor:
Vanesa Fernández-Majada, Patrick-Simon Welz, Maria A. Ermolaeva, Michael Schell, Alexander Adam, Felix Dietlein, David Komander, Reinhard Büttner, Roman K. Thomas, Björn Schumacher, Manolis Pasparakis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
CYLD is a deubiquitinase known to act as a tumour suppressor in different models of carcinogenesis. Here, the authors show that CYLD suppresses carcinogen-induced tumorigenesis by deubiquitinating p53 and promoting its stabilization and activation in
Externí odkaz:
https://doaj.org/article/79bd90df0bdb446e800325e92d9eaee1
Autor:
Paul Petrus, Jacob G. Smith, Kevin B. Koronowski, Siwei Chen, Tomoki Sato, Carolina M. Greco, Thomas Mortimer, Patrick-Simon Welz, Valentina M. Zinna, Kohei Shimaji, Marlene Cervantes, Daniela Punzo, Pierre Baldi, Pura Muñoz-Cánoves, Paolo Sassone-Corsi, Salvador Aznar Benitah
Publikováno v:
Science advances, vol 8, iss 26
Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue communication is mediated, in par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8459b22b8bf6c1e51e626fa03be29a05
https://escholarship.org/uc/item/41g4628h
https://escholarship.org/uc/item/41g4628h
Autor:
Patrick-Simon Welz
Publikováno v:
Journal of Investigative Dermatology. 141:1024-1030
The circadian clockwork evolved as an adaptation to daily environmental changes and allows temporal alignment of functions between cells and organs on a systemic level in complex multicellular organisms. These clock functions are particularly importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84143ec503030e1b4352e7ec8c493086
https://doi.org/10.1016/j.jid.2020.10.009
https://doi.org/10.1016/j.jid.2020.10.009
Autor:
Jacob G. Smith, Kevin B. Koronowski, Tomoki Sato, Carolina Greco, Paul Petrus, Amandine Verlande, Siwei Chen, Muntaha Samad, Ekaterina Deyneka, Lavina Mathur, Ronnie Blazev, Jeffrey Molendijk, Thomas Mortimer, Arun Kumar, Oleg Deryagin, Mireia Vaca-Dempere, Peng Liu, Valerio Orlando, Benjamin L. Parker, Pierre Baldi, Patrick-Simon Welz, Cholsoon Jang, Selma Masri, Salvador Aznar Benitah, Pura Muñoz-Cánoves, Paolo Sassone-Corsi
Expressed throughout the body, the circadian clock system achieves daily metabolic homeostasis at every level of physiology, with clock disruption associated with metabolic disease (1, 2). Molecular clocks present in the brain, liver, adipose, pancre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fce109a2d4a4a9872a6a963dd06ba0aa
https://doi.org/10.1101/2022.02.27.482160
https://doi.org/10.1101/2022.02.27.482160
Autor:
Thomas Mortimer, Valentina M. Zinna, Carmelo Laudanna, Paul Petrus, Kevin B. Koronowski, Jacob G. Smith, Carolina M. Greco, Elisa García-Lara, Arun Kumar, Mireia Vaca-Dempere, Oleg Deryagin, Stephen Forrow, Paolo Sassone-Corsi, Patrick-Simon Welz, Pura Muñoz-Cánoves, Salvador Aznar Benitah
In mammals, an integrated network of molecular oscillators drives daily rhythms of tissue-specific homeostatic processes. This network is required for maintaining health and can be compromised by physiological aging, disease, and lifestyle choices. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e68fd039a5ae2e6f8a866f31b9f70c3
https://doi.org/10.1101/2022.01.26.477844
https://doi.org/10.1101/2022.01.26.477844
Autor:
Patrick-Simon Welz, Roberta Carriero, Paolo Kunderfranco, Selma Masri, Siwei Chen, Arun Kumar, Pierre Baldi, Thomas Mortimer, Kenneth A. Dyar, Kevin B. Koronowski, Jacob G. Smith, Jiejun Shi, Oleg Deryagian, Salvador Aznar Benitah, Wei Li, Kohei Shimaji, José Manuel Monroy Kuhn, Paul Petrus, Muntaha Samad, Valentina M. Zinna, Carolina Magdalen Greco, Sung Kook Chun, Mireia Vaca-Dempere, Cassandra Van, Pura Muñoz-Cánoves, Paolo Sassone-Corsi, Marcus M. Seldin, Tomoki Sato, Dominik Lutter
Publikováno v:
Science Advances
Science advances, vol 7, iss 39
Sci. Adv. 7:eabi7828 (2021)
Science advances, vol 7, iss 39
Sci. Adv. 7:eabi7828 (2021)
Description
The inner workings of the clock system rely on communicating signals between distal tissues to maintain daily metabolism.
The mammalian circadian clock, expressed throughout the brain and body, controls daily metabolic homeostas
The inner workings of the clock system rely on communicating signals between distal tissues to maintain daily metabolism.
The mammalian circadian clock, expressed throughout the brain and body, controls daily metabolic homeostas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfee1665b6f51022f3d9d13b3b9a63f
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
The circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257be353c2be3d2989d62c1db35a524d
http://hdl.handle.net/2445/177900
http://hdl.handle.net/2445/177900