Evaluation of 4 quantification methods for monitoring 16 antibiotics and 1 beta-lactamase inhibitor in human serum by high-performance liquid chromatography with tandem mass spectrometry detection

Autor: Patrick, Seraissol, Thomas, Lanot, Sarah, Baklouti, Camille, Mané, Stéphanie, Ruiz, Michel, Lavit, Pascale, De Riols, Jean-Christophe, Garrigues, Peggy, Gandia

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, 2022, 219, pp.114900. ⟨10.1016/j.jpba.2022.114900⟩

Antibiotic (ATB) prescription in an intensive care unit (ICU) requires continuous monitoring of serum dosages due to the patient's pathophysiological condition. Dosing adjustment is necessary to achieve effective targeted concentrations. Since ICUs r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b73b95363fc525b851cb3af1655e3e6
https://hal.science/hal-03814985

Determination of Plasma Unbound Fraction of Voriconazole in Patients Treated With a Prophylactic or a Curative Treatment

Autor: Aurelie Florent, Etienne Chatelut, Georges Houin, Patrick Seraissol, Peggy Gandia

Publikováno v: Therapeutic Drug Monitoring. 36:752-758

BACKGROUND Voriconazole (VOR) is a triazole antifungal used in the curative treatment of invasive fungal infections and the prophylactic treatment of opportunistic fungal infections in immunocompromised patients. It is a drug for which therapeutic dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0808c3f83db2a33d134724393721ff0
https://doi.org/10.1097/ftd.0000000000000095

Is the unbound concentration of atazanavir of interest in therapeutic drug monitoring?

Autor: Pierre Delobel, Lise Cuzin, Etienne Chatelut, David Metsu, Christel Cinq-Frais, Peggy Gandia, Jacques Izopet, Patrick Seraissol

Publikováno v: Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2017, ⟨10.1111/fcp.12245⟩

To date, therapeutic drug monitoring (TDM) is carried out with antiretrovirals and is usually based on total concentrations (Ct ). However, for some patients, TDM does not reflect efficacy or the avoidance of toxicity as is the case for atazanavir (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd99ba4832ffaa9a1eaba9ae11625277
https://hal.archives-ouvertes.fr/hal-01907438

Quinine unbound concentration has to be used for therapeutic drug monitoring

Autor: Michel Lavit, Patrick Seraissol, Carlos de Pablos-Martinez, Etienne Chatelut, Peggy Gandia, Antoine Berry, Lydie Porte, François Fraissinet, Didier Concordet

Publikováno v: Therapeutic Drug Monitoring
Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2016, 38 (4), pp.556-7. ⟨10.1097/FTD.0000000000000304⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c82824914c4e2d0db8659e55d3e868f
https://hal.inrae.fr/hal-02634648

Décès médicamenteux impliquant le propofol et le cistracurium, deux molécules utilisées en anesthésiologie

Autor: M. Lavit, P. Gandia, Patrick Seraissol, M.-C. Céré, S. Nassar, F. Fraissinet

Publikováno v: Toxicologie Analytique et Clinique. 28:S39-S40

Objectif Description clinique et analytique d’un cas de deces apres administration intraveineuse de propofol et de cistracurium. Introduction Nous rapportons le cas de Mme X, 47 ans, sans antecedent particulier, infirmiere en milieu hospitalier, qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11d79da9afa0745579d0278008289c84
https://doi.org/10.1016/j.toxac.2016.03.067