Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Patrick Schlossbauer"'
Publikováno v:
Re:GEN Open, Vol 4, Iss 1, Pp 21-32 (2024)
Introduction: In the past decade, microRNAs (miRNAs), which are small, noncoding RNAs of ?22 nucleotides length, have gained attention as novel engineering tools for biopharmaceutical cell line development. As miRNAs provide the ability to fine-tune
Externí odkaz:
https://doaj.org/article/5a19ab4869a748beab4d00d04faf56e0
Autor:
Patrick Schlossbauer, Lukas Naumann, Florian Klingler, Madina Burkhart, René Handrick, Kathrin Korff, Christian Neusüß, Kerstin Otte, Friedemann Hesse
Publikováno v:
Engineering in Life Sciences, Vol 24, Iss 6, Pp n/a-n/a (2024)
Abstract Cell engineering strategies typically rely on energy‐consuming overexpression of genes or radical gene‐knock out. Both strategies are not particularly convenient for the generation of slightly modulated phenotypes, as needed in biosimila
Externí odkaz:
https://doaj.org/article/8dcdbbb84fc94f5d93f3c2f682b96283
Publikováno v:
Metabolic Engineering Communications, Vol 13, Iss , Pp e00181- (2021)
Oxygen deficiency (hypoxia) induces adverse effects during biotherapeutic protein production leading to reduced productivity and cell growth. Hypoxic conditions occur during classical batch fermentations using high cell densities or perfusion process
Externí odkaz:
https://doaj.org/article/e2006b5a53a64ffa9a20e718680e9f9d
Autor:
Simone Ladel, Patrick Schlossbauer, Johannes Flamm, Harald Luksch, Boris Mizaikoff, Katharina Schindowski
Publikováno v:
Pharmaceutics, Vol 11, Iss 8, p 367 (2019)
Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation during intranasal drug delivery. With increasing interest for intranasal pathways, adequate in vitro models are required. Here, porcine olfactory (OEPC) and
Externí odkaz:
https://doaj.org/article/04f060906b704f49a70b7559a3b64cc8
Autor:
Simone Ladel, Johannes Flamm, Arghavan Soleimani Zadeh, Dorothea Filzwieser, Julia-Christina Walter, Patrick Schlossbauer, Ralf Kinscherf, Katharina Lischka, Harald Luksch, Katharina Schindowski
Publikováno v:
Pharmaceutics, Vol 10, Iss 3, p 107 (2018)
Background: The use of therapeutic antibodies for the treatment of neurological diseases is of increasing interest. Nose-to-brain drug delivery is one strategy to bypass the blood brain barrier. The neonatal Fc receptor (FcRn) plays an important role
Externí odkaz:
https://doaj.org/article/bcc0181516f346f088d49f47f6be1f9a
Autor:
Lukas Naumann, Patrick Schlossbauer, Florian Klingler, Friedemann Hesse, Kerstin Otte, Christian Neusüß
Publikováno v:
Journal of Separation Science. 45:2034-2044
The analysis of monoclonal antibodies glycosylation is a crucial quality control attribute of biopharmaceutical drugs. High throughput screening approaches for antibody glycoform analysis are required in various stages of process optimization. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4530144633a40ba47fdb7de48995e6f4
https://doi.org/10.1002/jssc.202100865
https://doi.org/10.1002/jssc.202100865
Autor:
Martin Gamer, Karlheinz Holzmann, René Handrick, Simon Fischer, Patrick Schlossbauer, Benjamin Lindner, Anna Stadermann, Nadja Raab, Kerstin Otte, Sven Mathias, Nikolas Zeh
Publikováno v:
New Biotechnology. 66:79-88
Chinese Hamster Ovary (CHO) cells are the most frequently used biopharmaceutical production hosts, although industry is presently suffering from their variable recombinant product quality, insufficient long-term stability and low productivity. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6530a41cfce4883fcfd2a4434a99ba
https://doi.org/10.1016/j.nbt.2021.10.005
https://doi.org/10.1016/j.nbt.2021.10.005
Publikováno v:
Metabolic Engineering Communications, Vol 13, Iss, Pp e00181-(2021)
Metabolic Engineering Communications
Metabolic Engineering Communications
Oxygen deficiency (hypoxia) induces adverse effects during biotherapeutic protein production leading to reduced productivity and cell growth. Hypoxic conditions occur during classical batch fermentations using high cell densities or perfusion process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c296dfff6a1a6ab737dba13f121dcf0
http://www.sciencedirect.com/science/article/pii/S2214030121000213
http://www.sciencedirect.com/science/article/pii/S2214030121000213
Autor:
Boris Mizaikoff, Harald Luksch, Katharina Schindowski, Johannes Flamm, Patrick Schlossbauer, Simone Ladel
Publikováno v:
Pharmaceutics
Pharmaceutics; Volume 11; Issue 8; Pages: 367
Pharmaceutics, Vol 11, Iss 8, p 367 (2019)
Pharmaceutics; Volume 11; Issue 8; Pages: 367
Pharmaceutics, Vol 11, Iss 8, p 367 (2019)
Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation during intranasal drug delivery. With increasing interest for intranasal pathways, adequate in vitro models are required. Here, porcine olfactory (OEPC) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dbb615d54ca67977bf801b43077192
Autor:
Johannes Flamm, Boris Mizaikoff, Rebecca Hermann, Patrick Schlossbauer, Simone Ladel, Alina Handl, Helena Herzog, Thomas Hummel, Frank Maigler, Katharina Schindowski
Publikováno v:
Pharmaceutics
Volume 12
Issue 11
Volume 12
Issue 11
Although we have recently reported the involvement of neonatal Fc receptor (FcRn) in intranasal transport, the transport mechanisms are far from being elucidated. Ex vivo porcine olfactory tissue, primary cells from porcine olfactory epithelium (OEPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924426981c0f304b3dfe1f12c561bffc
https://doi.org/10.3390/pharmaceutics12111014
https://doi.org/10.3390/pharmaceutics12111014