Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Patrick Salois"'
Publikováno v:
Biology, Vol 13, Iss 2, p 87 (2024)
TREM2 is a critical innate immune receptor primarily expressed on myeloid-derived cells, such as microglia and macrophages. Mutations in TREM2 are linked to several neurodegenerative diseases including Alzheimer’s disease (AD). TREM2 can be cleaved
Externí odkaz:
https://doaj.org/article/a169e0b6c1a5422297ca6894957edaa3
Autor:
Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard, Shoukat Dedhar
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The architectural complexity and heterogeneity of the tumor microenvironment (TME) remains a substantial obstacle in the successful treatment of cancer. Hypoxia, caused by insufficient oxygen supply, and acidosis, resulting from the expulsion of acid
Externí odkaz:
https://doaj.org/article/a78bd5c3c72d4143937f4cd8eec87eef
Autor:
Paul C. McDonald, Christiane Cantin, Hafida Oamari, Alma Robert, Alex Pelletier, Anne Marcil, Myriam Banville, Suzanne Grothe, Stevo Radinovic, Cunle Wu, Mélanie Duchesne, Francois Benard, Nathalie Bousquet-Gagnon, Andrea Acel, Marie Parat, Maurizio Acchione, Annie Dulude, Shoukat Dedhar, Joseph Lau, Maria L. Jaramillo, Maureen D. O'Connor-McCourt, Yves Durocher, Christine Gadoury, Yves Fortin, Beatrice Paul-Roc, Yuneivy Cepero-Donates, Denis L'Abbé, Jason Baardsnes, Félix Malenfant, Anne E.G. Lenferink, Mylene Gosselin, Mehul Patel, Patrick Salois, Martin Lafrance, Oksana Nemirovsky, Paul Lachance, Shawn C. Chafe
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The architectural complexity and heterogeneity of the tumor microenvironment (TME) remains a substantial obstacle in the successful treatment of cancer. Hypoxia, caused by insufficient oxygen supply, and acidosis, resulting from the expulsion of acid
Autor:
Clint James, Louie Lamorte, Sonia Tremblay, Joannie Minville, Alex Pelletier, Daniel Rajotte, Bruno Simoneau, Patrick Salois, Louis Morency, Michael G. Cordingley, Patrick Deroy, Jianmin Duan, Claudio Sturino, Martin Duplessis, Martin Tremblay, Teddy Halmos, Richard Bethell, Sébastien Morin, Paul J. Edwards
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2781-2786
A HTS screen led to the identification of a benzofurano[3,2-d]pyrimidin-2-one core structure which upon further optimization resulted in 1 as a potent HIV-1 nucleotide competing reverse transcriptase inhibitor (NcRTI). Investigation of the SAR at N-1
Autor:
George Kukolj, Ivan A. D. Lessard, Mohamed El-Far, Jean-François Fortin, Yoav Peretz, Elizabeth Wardrop, Michael G. Cordingley, Charles Pellerin, Louise Pilote, Richard Bethell, Patrick Salois
Publikováno v:
Journal of Translational Medicine
Background Coexpression of CD160 and PD-1 on HIV-specific CD8+ T-cells defines a highly exhausted T-cell subset. CD160 binds to Herpes Virus Entry Mediator (HVEM) and blocking this interaction with HVEM antibodies reverses T-cell exhaustion. As HVEM
Publikováno v:
Gene. 334
Terminal differentiation of keratinocytes results in the formation of a cornified layer composed of cross-linked intracellular and extracellular material. Using a signal trap expression screening strategy, we have identified four cDNAs encoding secre
Autor:
Dengshun Miao, Rock Gingras, E Godin, Marie-Hélène Gaumond, David Goltzman, Gethin P. Thomas, Pierre Moffatt, Christian Lanctot, Patrick Salois
Publikováno v:
The Journal of biological chemistry. 278(50)
Although a number of secreted factors have been demonstrated to be bone regulators, none of these are unique to bone. Using a viral- based signal- trap strategy we have identified a novel gene we have termed " osteocrin." A 1280- bp mRNA encodes oste
Autor:
Marie-Hélène Gaumond, Pierre Moffatt, E Godin, Christian Lanctot, Patrick Salois, Natalie St-Amant
Publikováno v:
Nucleic acids research. 30(19)
We have developed a functional genomics tool to identify the subset of cDNAs encoding secreted and membrane-bound proteins within a library (the ‘secretome’). A Sindbis virus replicon was engineered such that the envelope protein precursor no lon