Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Patrick S. Hosford"'
Autor:
Isabel N. Christie, Shefeeq M. Theparambil, Alice Braga, Maxim Doronin, Patrick S. Hosford, Alexey Brazhe, Alexander Mascarenhas, Shereen Nizari, Anna Hadjihambi, Jack A. Wells, Adrian Hobbs, Alexey Semyanov, Andrey Y. Abramov, Plamena R. Angelova, Alexander V. Gourine
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113514- (2023)
Summary: During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen
Externí odkaz:
https://doaj.org/article/e103ac5e3e2a45a0b6df0577e2df1764
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100666- (2023)
Externí odkaz:
https://doaj.org/article/8b129cdbc9da4b84b4a046928fe48f99
Autor:
Patrick S. Hosford, Jack A. Wells, Shereen Nizari, Isabel N. Christie, Shefeeq M. Theparambil, Pablo A. Castro, Anna Hadjihambi, L. Felipe Barros, Iván Ruminot, Mark F. Lythgoe, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The mechanism of neurovascular coupling ensures that the brain energy supply is sufficient to meet demand. Here the authors show that in this mechanism CO2 plays an important role in neuronal activity-dependent regulation of local brain blood flow.
Externí odkaz:
https://doaj.org/article/0e7fd82c54eb4eecb447c0bf5d5c893f
Autor:
Anna Hadjihambi, Cristina Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Chris Donnelly, Christos Konstantinou, Nathan Davies, Abeba Habtesion, Alexander V. Gourine, Rajiv Jalan, Patrick S. Hosford
Publikováno v:
JHEP Reports, Vol 4, Iss 8, Pp 100509- (2022)
Background & Aims: Increased plasma ammonia concentration and consequent disruption of brain energy metabolism could underpin the pathogenesis of hepatic encephalopathy (HE). Brain energy homeostasis relies on effective maintenance of brain oxygenati
Externí odkaz:
https://doaj.org/article/61b571bae53140f4bb2037e851d603c1
Autor:
Shefeeq M. Theparambil, Patrick S. Hosford, Iván Ruminot, Olga Kopach, James R. Reynolds, Pamela Y. Sandoval, Dmitri A. Rusakov, L. Felipe Barros, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the e
Externí odkaz:
https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c
Autor:
Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial
Externí odkaz:
https://doaj.org/article/460633936e6841f2ab72308399796298
Autor:
Patrick S. Hosford, Jack A. Wells, Isabel N. Christie, Mark F. Lythgoe, Julian Millar, Alexander V. Gourine
Publikováno v:
Biosensors and Bioelectronics: X, Vol 3, Iss , Pp 100034- (2019)
A method for simultaneous electrochemical detection of brain tissue PO2 (PtO2) and pH changes together with neuronal activity using a modified form of fast cyclic voltammetry with carbon fiber electrodes is described. This technique has been develope
Externí odkaz:
https://doaj.org/article/5b3aab60e5f1482f8fb6cc3b7111df8c
Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity
Autor:
Shahriar Sheikhbahaei, Egor A. Turovsky, Patrick S. Hosford, Anna Hadjihambi, Shefeeq M. Theparambil, Beihui Liu, Nephtali Marina, Anja G. Teschemacher, Sergey Kasparov, Jeffrey C. Smith, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Circuits of the preBötzinger complex generate rhythms needed for breathing. Here, the authors provide evidence, using a combination of chemogenetic approaches and approaches to inhibit vesicular release, that astrocytes play a role in regulating res
Externí odkaz:
https://doaj.org/article/988bcc66305d4c098978f289c873fba5
Autor:
Patrick S. Hosford, Natalia Ninkina, Vladimir L. Buchman, Jeffrey C. Smith, Nephtali Marina, Shahriar SheikhBahaei
Publikováno v:
Brain Sciences, Vol 10, Iss 9, p 583 (2020)
Synuclein (α, β, and γ) proteins are highly expressed in presynaptic terminals, and significant data exist supporting their role in regulating neurotransmitter release. Targeting the gene encoding α-synuclein is the basis of many animal models of
Externí odkaz:
https://doaj.org/article/6ce6a6308b2c44c1bcccb101ee746cff
Autor:
Anna Hadjihambi, Christos Konstantinou, Jan Klohs, Katia Monsorno, Adrien Le Guennec, Chris Donnelly, I. Jane Cox, Anjali Kusumbe, Patrick S. Hosford, Ugo Soffientini, Salvatore Lecca, Manuel Mameli, Rajiv Jalan, Rosa Chiara Paolicelli, Luc Pellerin
Publikováno v:
Journal of Hepatology, 78 (1)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has been associated with mild cerebral dysfunction and cognitive decline, although the exact pathophysiological mechanism remains ambiguous. Using a diet-induced model of NAFLD and monocarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8e269bedcede3903915a63f04501a8
https://hdl.handle.net/20.500.11850/588285
https://hdl.handle.net/20.500.11850/588285
