Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Patrick Robert Verhoest"'
Autor:
Nandini Chaturbhai Patel, Dafydd R. Owen, Rhonda D. Cardin, Karen J. Coffman, Jean G. Sathish, Devendra K. Rai, Heather Eng, Charlotte Moira Norfor Allerton, Jack C. Lee, Britton Boras, Melissa Avery, Qingyi Yang, Eugene P. Kadar, Anthony Carlo, Annaliesa S. Anderson, Matthew R. Reese, Li Di, Jisun Lee, Lisa Aschenbrenner, Stephen Noell, Lawrence W. Updyke, Martin Pettersson, Scott A. Gibson, Matthew F. Sammons, Al E. Stewart, Yuao Zhu, Alyssa Dantonio, Stephen W. Mason, Brett L. Hurst, Ketan S. Gajiwala, Claire M. Steppan, Liuqing Wei, Patrick Robert Verhoest, Samantha Elizabeth Greasley, Simon Berritt, R. Scott Obach, RoseAnn Ferre, Ravi Shankar P. Singh, Amit S. Kalgutkar, Jonathan J. Novak, Kevin Ogilvie, Wei Liu, Jamison B. Tuttle
Publikováno v:
Science. 374:1586-1593
Path to another drug against COVID-19 The rapid development of vaccines has been crucial in battling the ongoing COVID-19 pandemic. However, access challenges remain, breakthrough infections occur, and emerging variants present increased risk. Develo
Autor:
Alyssa Dantonio, Heather Eng, Nandini Chaturbhai Patel, Anthony Carlo, Liuqing Wei, Annaliesa S. Anderson, Ravi Shankar P. Singh, Lawrence W. Updyke, Amit S. Kalgutkar, Jamison B. Tuttle, Lisa Aschenbrenner, Simon Berritt, Ketan S. Gajiwala, Jack C. Lee, Devendra K. Rai, Martin Pettersson, Matthew R. Reese, Jisun Lee, Stephen W. Mason, Eugene P. Kadar, RoseAnn Ferre, Melissa Avery, Li Di, Charlotte Moira Norfor Allerton, R. Scott Obach, Scott A. Gibson, Stephen Noell, Patrick Robert Verhoest, Kevin Ogilvie, Jonathan J. Novak, Brett L. Hurst, Dafydd R. Owen, Rhonda D. Cardin, Wei Liu, Yuao Zhu, Karen J. Coffman, Claire M. Steppan, Jean G. Sathish, Samantha Elizabeth Greasley, Matthew F. Sammons, Qingyi Yang, Britton Boras, Al E. Stewart
The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become an established global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0de6febfa535f3995194517e34278b9
https://doi.org/10.1101/2021.07.28.21261232
https://doi.org/10.1101/2021.07.28.21261232
Autor:
Patrick Robert Verhoest, David Hepworth, Tristan S. Maurer, Charlotte Moira Norfor Allerton, Martin Paul Edwards
Publikováno v:
Drug discovery today. 27(2)
Successful small-molecule drug design requires a molecular target with inherent therapeutic potential and a molecule with the right properties to unlock its potential. Present-day drug design strategies have evolved to leave little room for improveme
Autor:
Nandini Chaturbhai Patel, Jennifer L. Liras, Patrick Trapa, Mark A. West, Tristan S. Maurer, Bo Feng, Patrick Robert Verhoest, Simone Sciabola, Travis T. Wager, Xinjun Hou
Publikováno v:
ACS chemical neuroscience. 12(6)
One of the objectives within the medicinal chemistry discipline is to design tissue targeting molecules. The objective of tissue specificity can be either to gain drug access to the compartment of interest (e.g., the CNS) for Neuroscience targets or
Autor:
Nicholas W. Warne, Mikael Dolsten, Kathy Fernando, John E. Burkhardt, Andrew E. Prigodich, Patrick Robert Verhoest, Charlotte Moira Norfor Allerton, Shuntai Wang
Publikováno v:
Drug discovery today. 26(10)
Innovation has a crucial role in developing breakthrough drugs and vaccines that can change patients’ lives. To better understand this role, we evaluated recent outcomes for assets developed using different types of innovation. Although all approac
Autor:
Erica C. Dresselhaus, Leah Cleary, Gayathri Ramaswamy, Michael Marconi, Patrick Robert Verhoest, Edel Evrard, Uthpala Seneviratne, Christopher amEnde, Martin Pettersson, Ethan Lawrence Fisher, Jamison B. Tuttle, Lorraine F. Lanyon, Longfei Xie, Emily Sylvain, Travis T. Wager, Butler Todd W, John M. Humphrey, Claire M. Steppan, Simone Sciabola, Douglas Scott Johnson, Zhen Huang, Christopher J Helal, Michael Eric Green, Paramita Mukherjee
Publikováno v:
SSRN Electronic Journal.
Apolipoprotein E (apoE) is a 34 kDa key lipid transport protein in both the brain and the periphery. In the brain, it is produced predominantly by astrocytes and has been shown to play an important role in promoting neurite outgrowth and synaptogenes
Autor:
Nandini Chaturbhai Patel, Richard V. Coelho, Christopher John Helal, Chewah Lee, Anabella Villalobos, Shawn D. Doran, Joseph Michael Young, Robert J. Mather, Simone Sciabola, Erik Alphie Lachapelle, John T. Lazzaro, Thomas Allen Chappie, Patrick Robert Verhoest, Zoë A. Hughes, Marc B. Skaddan, Elizabeth Mary Beck, John M. Humphrey, Kyle Kuszpit, Laigao Chen, Lei Zhang, Kenneth R. Zasadny, Kuo-Hsien Fan
Publikováno v:
Journal of Medicinal Chemistry. 60:8538-8551
As part of our effort in identifying phosphodiesterase (PDE) 4B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to identify a positron emission tomography (PET) ligand to enable target occupancy measuremen
Autor:
Daniel P. Walker, Antonia F. Stepan, Mark A. Moen, Gregg D. Cappon, Christopher Houle, Annie C Won, Joshua R. Dunetz, Michael John Bohanon, Lei Zhang, Marc B. Skaddan, Patrick Robert Verhoest, Susan E. Drozda, Xinjun Hou, Kenneth R. Zasadny, Julie Cianfrogna, Deborah L. Smith, Ann S. Wright, John T. Lazzaro, Steven Victor O'neil, Patrick Trapa, Emily Miller, Somraj Ghosh, Gabriela Barreiro, John M. Marcek, Margaret M. Zaleska, Jason Barricklow, Michelle Marie Claffey, Lois K. Chenard, Jessica Mancuso, Christopher L. Shaffer, Jessica Whritenour, Gayatri Balan, Brian P. Boscoe, Vinod D. Parikh, Karen J. Coffman, Laigao Chen, Isao Sakurada, Jamison B. Tuttle, Matthew R. Reese, Karki Kapil Kumar
Publikováno v:
Journal of Medicinal Chemistry. 60:7764-7780
We previously observed a cutaneous type IV immune response in nonhuman primates (NHP) with the mGlu5 negative allosteric modulator (NAM) 7. To determine if this adverse event was chemotype- or mechanism-based, we evaluated a distinct series of mGlu5
Autor:
Kimberly F. Fennell, Zhijun Kang, Hirokazu Ueno, William E. Hoffman, Mihály Hajós, Thomas Allen Chappie, Mary Piotrowski, Noha Maklad, Jayvardhan Pandit, John M. Humphrey, Anne W. Schmidt, Edward X. Yang, Patrick Robert Verhoest, Bethany L. Kormos, Jiemin Lu, Eric P. Arnold, Cheng Chang, Christopher J. Schmidt, Robin J. Kleiman, Rebecca E. O’Connor, John F. Harms, Scot Richard Mente, Christopher John Helal, Tracey Boyden, Chewah Lee, Laura McDowell, Michael D. Forman
Publikováno v:
Journal of Medicinal Chemistry. 60:5673-5698
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the biology of PDE2A inhibition, we sought to identify potent PDE2A inhibitors with improved brain pe
Autor:
Christopher W. am Ende, Ethan Lawrence Fisher, Erica C. Dresselhaus, Leah Cleary, John M. Humphrey, Edelweiss Evrard, Douglas S. Johnson, Patrick Robert Verhoest, Jamison B. Tuttle, Travis T. Wager, Longfei Xie, Emily Sylvain, Zhen Huang, Martin Pettersson, Uthpala Seneviratne, Lorraine F. Lanyon, Michael Marconi, Claire M. Steppan, Gayathri Ramaswamy, Simone Sciabola, Christopher John Helal, Michael Eric Green, Butler Todd W, Paramita Mukherjee
Publikováno v:
Cell Chem Biol
Summary Utilizing a phenotypic screen, we identified chemical matter that increased astrocytic apoE secretion in vitro. We designed a clickable photoaffinity probe based on a pyrrolidine lead compound and carried out probe-based quantitative chemical