Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Patrick Robberecht"'
Autor:
Régine Hierso, Alain Couvineau, Nadège Jamin, Yossan-Var Tan, Emilie Ceraudo, Jean-Michel Neumann, Patrick Robberecht, Samuel Murail, Christiane Rouyer-Fessard, Pascal Nicole, Marc Laburthe, Jean-Claude Robert
Publikováno v:
The FASEB Journal. 26:2060-2071
Vasoactive intestinal peptide (VIP) plays a major role in pathophysiology. Our previous studies demonstrated that the VIP sequence 6-28 interacts with the N-terminal ectodomain (N-ted) of its receptor, VPAC1. Probes for VIP and receptor antagonist PG
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783(9):1663-1672
Like for most transmembrane proteins, translation of G protein-coupled receptors (GPCRs) mRNA takes place at the endoplasmic reticulum (ER) where they are synthesized, folded and assembled. The molecular mechanisms involved in the transport process o
Autor:
Ingrid Langer, Patrick Robberecht
Publikováno v:
Biochemical Society Transactions. 35:724-728
An actual paradigm for activation and regulation of the GPCR (G-protein-coupled receptors)/seven-transmembrane helix family of receptors essentially emerges from extensive studies of the largest family of receptors, the GPCR-A/rhodopsin family. The m
Publikováno v:
Cellular Signalling. 18:2121-2130
After stimulation with agonist, G protein coupled receptors (GPCR) undergo conformational changes that allow activation of G proteins to transduce the signal, followed by phosphorylation by kinases and arrestin binding to promote receptor internaliza
Autor:
Patrick Robberecht, Luo Xu, Pascale Vertongen, Inge Depoortere, Theo L. Peeters, Magali Waelbroeck
Publikováno v:
Biochemical Pharmacology. 70:879-887
The motilin receptor (MTLR) represents a clinically useful pharmacological target, as agonists binding to the MTLR have gastroprokinetic properties. In order to compare the molecular basis for interaction of the MTLR with motilin and with the non-pep
Autor:
Ingrid Langer, Nathalie Gaspard, Pascale Vertongen, Jean-Marie Vanderwinden, Christelle Langlet, Patrick Robberecht
Publikováno v:
Journal of Biological Chemistry. 280:28034-28043
When exposed to vasoactive intestinal peptide (VIP), the human wild type VPAC1 receptor expressed in Chinese hamster ovary (CHO) cells is rapidly phosphorylated, desensitized, and internalized in the endosomal compartment and is not re-expressed at t
Publikováno v:
British Journal of Pharmacology. 144:994-1001
Vasoactive intestinal peptide (VIP) has been demonstrated in intestinal mucosal neurones and elicits chloride secretion from enterocytes. These findings have led to the proposal that VIP is a secretomotor neurotransmitter. Confirmation of such a role
Publikováno v:
Journal of Molecular Endocrinology. 34:405-414
The VPAC2 receptor, as all members of the G-protein-coupled receptor (GPCR)-B family, has two highly conserved motifs in the third intracellular (IC3) loop: a lysine and a leucine located at the amino-terminus and two basic residues separated by a le
Autor:
Ingrid Langer, Patrick Robberecht
Publikováno v:
Cellular Signalling. 17:17-24
The vasoactive intestinal polypeptide (VIP) VPAC1 receptor is preferentially coupled to Galphas protein that stimulates adenylate cyclase activity and also to Galphaq and Galphai proteins that stimulate the inositol phosphate/calcium pathway. Previou
Publikováno v:
Peptides. 25:2079-2086
Using a monoclonal antibody interacting with the extracellular amino-terminus of the human VPAC2 receptor but that did not interfere with ligand binding, we measured by flow cytometry receptor internalization and trafficking induced by full agonists,