Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrick Rene Angibaud"'
Autor:
A Mariën, Manfred Jung, Patrick Rene Angibaud, Wim Floren, Michel Janicot, T. Geerts, K. Van Emelen, Boudewijn Janssens, Luc Andries, J. Van Dun, Peter King, J. Arts, L Janssen, Dana L. Johnson, R W Tuman
Publikováno v:
British Journal of Cancer
R306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f68efcc8c75d57eb34dbb5ff9cf3937
https://doi.org/10.1038/sj.bjc.6604025
https://doi.org/10.1038/sj.bjc.6604025
Publikováno v:
Tetrahedron Letters. 46:8027-8031
Alcohols are solvents of choice to react boronates, aldehydes and either primary or secondary amines. Thus, while the reaction proceeds sluggishly, or not at all, in aprotic solvents, the desired aminoacids are in most cases obtained in high yields w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d939f5de5f502978029a20b099d93796
https://doi.org/10.1016/j.tetlet.2005.09.060
https://doi.org/10.1016/j.tetlet.2005.09.060
Autor:
Dave W. End, Virginie Sophie Poncelet, Walter Filliers, Marc Gaston Venet, Yannick Aimé Eddy Ligny, Patrick Rene Angibaud, Philippe Muller, Rudy Laurent Maria Broeckx
Publikováno v:
European Journal of Organic Chemistry. 2004:479-486
The discovery that post-translational farnesylation of Ras oncoprotein was an essential step in exercising its biological effect led to the design of farnesyl protein transferase inhibitors (FTIs) in order to control growth of tumors bearing Ras muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e23f256bfad4f3e0ab2442821fc1ca42
https://doi.org/10.1002/ejoc.200300538
https://doi.org/10.1002/ejoc.200300538
Autor:
Patrick Rene Angibaud, Eddy Jean Edgard Freyne, Christophe Meyer, Jacky Van Dun, Gerda Smets, Marc Venet, Isabelle Noëlle Constance Pilatte, Laurence Mevellec, Virginie Sophie Poncelet, Bruno Roux, Geert Mannens, Ashis K. Saha, David William End, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patricia Lezouret
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4361-4364
Replacement of the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA series by a 4-methyl-1,2,4-triazol-3-yl group gave us compounds with similar structure-activity relationship profiles showing that this triazole is potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c04ec35bf3fe1b70503850f6984927
https://doi.org/10.1016/j.bmcl.2003.09.043
https://doi.org/10.1016/j.bmcl.2003.09.043
Autor:
Gerda Smets, Laurence Mevellec, Michel Janicot, Pieter Van Remoortere, Bruno Roux, Yannick Aimé Eddy Ligny, Isabelle Noëlle Constance Pilatte, Jacky Van Dun, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patrick Rene Angibaud, Geert Mannens, Marc Venet, David William End, Philippe Muller, Christophe Meyer, Patricia Lezouret, Siegrid Damsch, Eddy Jean Edgard Freyne, Virginie Sophie Poncelet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4365-4369
A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d7d9eb0ec5e2c21ab43464526d04f9
https://doi.org/10.1016/j.bmcl.2003.08.080
https://doi.org/10.1016/j.bmcl.2003.08.080
Autor:
Isabelle Noëlle Constance Pilatte, Walter Wouters, Geert Mannens, Yannick Aimé Eddy Ligny, Marc Venet, Pieter Van Remoortere, David W. End, Philippe Muller, Ann Devine, Patrick Rene Angibaud, Gerda Smets, Jacky Van Dun, Xavier Bourdrez, Stacy Skrzat, Virginie Sophie Poncelet, Eddy Jean Edgard Freyne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1543-1547
The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b54561efa14f8a494a0c6d5b6e93280
https://doi.org/10.1016/s0960-894x(03)00180-x
https://doi.org/10.1016/s0960-894x(03)00180-x
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783540331193
Over a decade has passed since the first report describing farnesyl protein transferase (FTase)and tetrapeptide inhibitors triggered a search for small-molecule inhibitors that could be developedas oral therapeutics. There are now several farnesyl pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8629d507b9056c8cfe7b9ec4f5f9cd3
https://doi.org/10.1007/7355_2006_003
https://doi.org/10.1007/7355_2006_003
