Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Patrick Rabe"'
Autor:
Raphael Reinbold, Ingvild C. Hvinden, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J. Clifton, Fraser A. Armstrong, James S. O. McCullagh, Jo Redmond, Chiara Bardella, Martine I. Abboud, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The development of IDH variant inhibitors is a breakthrough as it is the first time metabolism has been successfully targeted by small molecule drugs in cancer. Here the authors report studies on resistance to the pioneer drug ivosidenib leading to i
Externí odkaz:
https://doaj.org/article/e3e859d6d730417f8d6ec356de38fe1b
Autor:
Agata Butryn, Philipp S. Simon, Pierre Aller, Philip Hinchliffe, Ramzi N. Massad, Gabriel Leen, Catherine L. Tooke, Isabel Bogacz, In-Sik Kim, Asmit Bhowmick, Aaron S. Brewster, Nicholas E. Devenish, Jürgen Brem, Jos J. A. G. Kamps, Pauline A. Lang, Patrick Rabe, Danny Axford, John H. Beale, Bradley Davy, Ali Ebrahim, Julien Orlans, Selina L. S. Storm, Tiankun Zhou, Shigeki Owada, Rie Tanaka, Kensuke Tono, Gwyndaf Evans, Robin L. Owen, Frances A. Houle, Nicholas K. Sauter, Christopher J. Schofield, James Spencer, Vittal K. Yachandra, Junko Yano, Jan F. Kern, Allen M. Orville
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Currently many of the time resolved serial femtosecond (SFX) crystallography experiments are done with light driven protein systems, whereas the reaction initiation for non-light triggered enzymes remains a major bottle neck. Here, the authors presen
Externí odkaz:
https://doaj.org/article/55ce2079723b464484f4eed86828b06d
Autor:
Patrick Rabe, John H. Beale, Agata Butryn, Pierre Aller, Anna Dirr, Pauline A. Lang, Danny N. Axford, Stephen B. Carr, Thomas M. Leissing, Michael A. McDonough, Bradley Davy, Ali Ebrahim, Julien Orlans, Selina L. S. Storm, Allen M. Orville, Christopher J. Schofield, Robin L. Owen
Publikováno v:
IUCrJ, Vol 7, Iss 5, Pp 901-912 (2020)
Cryogenic X-ray diffraction is a powerful tool for crystallographic studies on enzymes including oxygenases and oxidases. Amongst the benefits that cryo-conditions (usually employing a nitrogen cryo-stream at 100 K) enable, is data collection of diox
Externí odkaz:
https://doaj.org/article/541ddf2ff1b14f87878d1b366c92c115
Autor:
Felix Schalk, Cene Gostinčar, Nina B. Kreuzenbeck, Benjamin H. Conlon, Elisabeth Sommerwerk, Patrick Rabe, Immo Burkhardt, Thomas Krüger, Olaf Kniemeyer, Axel A. Brakhage, Nina Gunde-Cimerman, Z. Wilhelm de Beer, Jeroen S. Dickschat, Michael Poulsen, Christine Beemelmanns
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Fungus-growing termites have optimized the decomposition of recalcitrant plant biomass to access valuable nutrients by engaging in a tripartite symbiosis with complementary contributions from a fungal mutualist and a codiversified gut microbiome. Thi
Externí odkaz:
https://doaj.org/article/5dafb19430084cc0a7decc02b9070168
Autor:
Jeroen S. Dickschat, Jan Rinkel, Patrick Rabe, Arman Beyraghdar Kashkooli, Harro J. Bouwmeester
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 1770-1780 (2017)
The product obtained in vitro from a diterpene synthase encoded in the genome of the bacterium Chitinophaga pinensis, an enzyme previously reported to have germacrene A synthase activity during heterologous expression in Escherichia coli, was identif
Externí odkaz:
https://doaj.org/article/d6984223210d45fb9ee0a4d4613b853d
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2317-2324 (2016)
The stereochemical course of the cyclisation reaction catalysed by the bacterial 1,8-cineol synthase from Streptomyces clavuligerus was investigated using stereospecifically deuterated substrates. In contrast to the well investigated plant enzyme fro
Externí odkaz:
https://doaj.org/article/c616bf18a409451ea9d208536603b02a
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1839-1850 (2016)
The products obtained by incubation of farnesyl diphosphate (FPP) with six purified bacterial terpene cyclases were characterised by one- and two-dimensional NMR spectroscopic methods, allowing for a full structure elucidation. The absolute configura
Externí odkaz:
https://doaj.org/article/27bbfd4c31544224836249a53d6adbe2
Autor:
Xinlu Chen, Katrin Luck, Patrick Rabe, Christopher QD Dinh, Gad Shaulsky, David R Nelson, Jonathan Gershenzon, Jeroen S Dickschat, Tobias G Köllner, Feng Chen
Publikováno v:
eLife, Vol 8 (2019)
Terpenoids are enormously diverse, but our knowledge of their biosynthesis and functions is limited. Here we report on a terpene synthase (DdTPS8)-cytochrome P450 (CYP521A1) gene cluster that produces a novel C12 trisnorsesquiterpene and affects the
Externí odkaz:
https://doaj.org/article/8cd672daf56a423c94c38bc226494c24
Autor:
Patrick Rabe, Jeroen S. Dickschat
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1380-1394 (2016)
Farnesyl diphosphate (FPP) and all fifteen positional isomers of (13C1)FPP were enzymatically converted by the bacterial terpene cyclases corvol ether synthase from Kitasatospora setae, the epi-cubebol synthase from Streptosporangium roseum, and the
Externí odkaz:
https://doaj.org/article/f6f57cceded2401a9a5d0f9935e38c71
Autor:
Patrick Rabe, Tim A. Klapschinski, Nelson L. Brock, Christian A. Citron, Paul D’Alvise, Lone Gram, Jeroen S. Dickschat
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1796-1801 (2014)
Tropodithietic acid (TDA) is a structurally unique sulfur-containing antibiotic from the Roseobacter clade bacterium Phaeobacter inhibens DSM 17395 and a few other related species. We have synthesised several structural analogues of TDA and used them
Externí odkaz:
https://doaj.org/article/23a2060ea95f40e89a77c922d8a4ec76