Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Patrick R. Verhoest"'
Autor:
Dafydd R, Owen, Charlotte M N, Allerton, Annaliesa S, Anderson, Lisa, Aschenbrenner, Melissa, Avery, Simon, Berritt, Britton, Boras, Rhonda D, Cardin, Anthony, Carlo, Karen J, Coffman, Alyssa, Dantonio, Li, Di, Heather, Eng, RoseAnn, Ferre, Ketan S, Gajiwala, Scott A, Gibson, Samantha E, Greasley, Brett L, Hurst, Eugene P, Kadar, Amit S, Kalgutkar, Jack C, Lee, Jisun, Lee, Wei, Liu, Stephen W, Mason, Stephen, Noell, Jonathan J, Novak, R Scott, Obach, Kevin, Ogilvie, Nandini C, Patel, Martin, Pettersson, Devendra K, Rai, Matthew R, Reese, Matthew F, Sammons, Jean G, Sathish, Ravi Shankar P, Singh, Claire M, Steppan, Al E, Stewart, Jamison B, Tuttle, Lawrence, Updyke, Patrick R, Verhoest, Liuqing, Wei, Qingyi, Yang, Yuao, Zhu
Publikováno v:
Science (New York, N.Y.). 374(6575)
The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the healthcare response to countering the ongo
Autor:
Christopher J. Helal, Eric P. Arnold, Tracey L. Boyden, Cheng Chang, Thomas A. Chappie, Kimberly F. Fennell, Michael D. Forman, Mihaly Hajos, John F. Harms, William E. Hoffman, John M. Humphrey, Zhijun Kang, Robin J. Kleiman, Bethany L. Kormos, Erik A. LaChapelle, Che-Wah Lee, Jiemin Lu, Noha Maklad, Laura McDowell, Scot Mente, Rebecca E. O’Connor, Jayvardhan Pandit, Mary Piotrowski, Anne W. Schmidt, Christopher J. Schmidt, Hirokazu Ueno, Patrick R. Verhoest, Edward X. Yang
Publikováno v:
Journal of medicinal chemistry. 61(8)
Publikováno v:
Journal of the American Chemical Society. 123:10942-10953
A highly convergent, stereocontrolled total synthesis of the potent antiproliferative agent (+)-phorboxazole A (1) has been achieved. Highlights of the synthesis include: modified Petasis−Ferrier rearrangements for assembly of both the C(11−15) a
Publikováno v:
Organic Letters. 1:913-916
[formula: see text] In this, the second of two Letters, we describe the efficient assembly of (+)-4, a C(20-28) subtarget for the total synthesis of phorboxazoles A (1) and B (2). The synthesis was achieved in 12 linear steps (20% overall yield) via
Publikováno v:
Organic Letters. 1:909-912
[formula: see text] In this, the first of two letters, we outline our overall strategy for the total synthesis of phorboxazoles A (1) and B (2), rare oxazole-containing macrolides possessing extraordinary antimitotic activity, and describe the assemb
Autor:
Qiyan Lin, Kiyoshi Nakayama, Patrick R. Verhoest, Christopher S. Brook, Noriaki Murase, Mark D. McBriar, Linghang Zhuang, Armen M. Boldi, William H. Moser, Amos B. Smith
Publikováno v:
Tetrahedron Letters. 38:8667-8670
In this Letter, the first in a series of three, we outline our overall strategy and describe the assembly of a C(29–48) EF-ring advanced intermediate for the total synthesis of the spongistatins, rare and structurally unique polyether macrolides wi
Autor:
Alexander Rochester New York Us Kover, James T. Loch, L.Paul Rosenberg, Simon F. Semus, John Zongrone, Anthony C. Machulskis, James C. Blosser, John C. Gordon, Patrick R. Verhoest, Sally A. McCreedy, Edwin S. C. Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2525-2530
To improve receptor binding affinity and to investigate functional selectivity of 2,8-dimethyl-1-oxa-8-azaspiro[4.5]decan-3-one acetylhydrazone 2 at muscarinic receptor subtypes, a series of acylhydrazones A was synthesized. The SAR indicates that th
Autor:
Patrick R, Verhoest, Kari R, Fonseca, Xinjun, Hou, Caroline, Proulx-Lafrance, Michael, Corman, Christopher J, Helal, Michelle M, Claffey, Jamison B, Tuttle, Karen J, Coffman, Shenpinq, Liu, Frederick, Nelson, Robin J, Kleiman, Frank S, Menniti, Christopher J, Schmidt, Michelle, Vanase-Frawley, Spiros, Liras
Publikováno v:
Journal of medicinal chemistry. 55(21)
6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943) is a novel PDE9A inhibitor identified using parallel synthetic chemistry and structure-based drug de
Publikováno v:
Journal of the American Chemical Society. 123:4834-4836
A highly convergent, stereocontrolled total synthesis of the potent antiproliferative agent (+)phorboxazole A (1) has been achieved. Highlights of the synthesis include: modified Petasis-Ferrier rearrangements for assembly of both the C(11-15) and C(
Publikováno v:
ChemInform. 27