Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Patrick R. O'Neill"'
Publikováno v:
GPCRs as Therapeutic Targets. :897-945
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f4924c69eac5bf0624683268f27ea32
https://doi.org/10.1002/9781119564782.ch25
https://doi.org/10.1002/9781119564782.ch25
Autor:
Christian E. Pedersen, Daniel C. Castro, Madelyn M. Gray, Zhe C. Zhou, Sean C. Piantadosi, Raajaram Gowrishankar, Shane A. Kan, Patrick J. Murphy, Patrick R. O’Neill, Michael R. Bruchas
Medial nucleus accumbens shell (mNAcSh) is a critical brain region for driving motivated behaviors. Despite this well-established role, the underlying reward processing of individual neurons, circuits and cell-types within mNAcSh remains largely unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1cad7c204d9b5d84d0624e6b9a95c9e
https://doi.org/10.1101/2022.09.18.508426
https://doi.org/10.1101/2022.09.18.508426
Autor:
Kyle E. Parker, Kasey S. Girven, Abigail J. Elerding, Sofia E. Shirley, Robert W. Gereau, Roger K. Sunahara, Alexis M. Vasquez, M. Christine Stander, Kelly K.L. Ma, Patrick R. O’Neill, Jun Nan Li, Tommaso Patriarchi, Vani Kalyanaraman, Narasimhan Gautam, Vijay K. Samineni, Sherri K. Vogt, Lin Tian, Judy J. Yoo, Michael R. Bruchas, Skylar M. Spangler, Bobbie J. Brown, Raaj Gowrishankar, Bryan A. Copits, Xenia Meshik
Publikováno v:
Neuron. 109:1791-1809.e11
Optical manipulations of genetically defined cell types have generated significant insights into the dynamics of neural circuits. While optogenetic activation has been relatively straightforward, rapid and reversible synaptic inhibition has proven mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ddc3645198435aaeef220256a6eb37
https://doi.org/10.1016/j.neuron.2021.04.026
https://doi.org/10.1016/j.neuron.2021.04.026
Cells experience physical deformations to the plasma membrane that can modulate cell behaviors like migration. Understanding the molecular basis for how physical cues affect dynamic cellular responses requires new approaches that can physically pertu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44cf6328cf07f052e9341d0e09bbba9
https://europepmc.org/articles/PMC7081452/
https://europepmc.org/articles/PMC7081452/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1749
Subcellular optogenetics allows specific proteins to be optically activated or inhibited at a restricted subcellular location in intact living cells. It provides unprecedented control of dynamic cell behaviors. Optically modulating the activity of si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d640f16701fbf6c5dfb5459807874b87
https://pubmed.ncbi.nlm.nih.gov/29526006
https://pubmed.ncbi.nlm.nih.gov/29526006
Publikováno v:
Methods in Molecular Biology ISBN: 9781493977000
Subcellular optogenetics allows specific proteins to be optically activated or inhibited at a restricted subcellular location in intact living cells. It provides unprecedented control of dynamic cell behaviors. Optically modulating the activity of si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf34bdf4bf3fd6d174cb044c7e7a0ac6
https://doi.org/10.1007/978-1-4939-7701-7_22
https://doi.org/10.1007/978-1-4939-7701-7_22
Autor:
C. Stander, A. Vasquez, Roger K. Sunahara, Michael R. Bruchas, Vijay K. Samineni, Patrick R. O’Neill, Judy J. Yoo, Robert W. Gereau, Kyle E. Parker, Bryan A. Copits
Publikováno v:
The Journal of Pain. 20:S60-S61
The development of diverse molecular tools to manipulate the activity of defined cell types has greatly accelerated our understanding of the neural circuits underlying complex behaviors. The most commonly used opsins are light-gated ion channels or p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768875de074483f24c3b007f30d4da31
https://doi.org/10.1016/j.jpain.2019.02.040
https://doi.org/10.1016/j.jpain.2019.02.040
Autor:
Narasimhan Gautam, Patrick R. O’Neill
Publikováno v:
Photochemical & Photobiological Sciences. 14:1578-1585
Optogenetic tools have recently been developed that enable dynamic control over the activities of select signaling proteins. They provide the unique ability to rapidly turn signaling events on or off with subcellular control in living cells and organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4965dc68e22c238ec212a1cc92251536
https://doi.org/10.1039/c5pp00171d
https://doi.org/10.1039/c5pp00171d
Publikováno v:
Molecular Biology of the Cell
Cdc42 is believed to play an important role in controlling the polarity of migrating cells, but it has not been possible to directly determine the effects of localized Cdc42 activity. Optogenetic activation of Cdc42 at one side of the cell was used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ad33e6e7ac2db256727e44a7d79455
https://pubmed.ncbi.nlm.nih.gov/26941336
https://pubmed.ncbi.nlm.nih.gov/26941336
Publikováno v:
The Journal of Physical Chemistry C. 115:24061-24066
We report UV excitation through the DNA bases as a universal pathway to visible emission from DNA stabilized silver cluster fluorophores (AgDNAs). AgDNAs with peak emissions throughout the visible spectrum all exhibit two peaks in fluorescence excita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6c968761fbad461942a317d64bf0808
https://doi.org/10.1021/jp206110r
https://doi.org/10.1021/jp206110r