Výsledky vyhledávání - "Patrick R, Melugin"

Structured tracking of alcohol reinforcement (STAR) for basic and translational alcohol research

Autor: Alex R. Brown, Hannah E. Branthwaite, Zahra Z. Farahbakhsh, Snigdha Mukerjee, Patrick R. Melugin, Keaton Song, Habiba Noamany, Cody A. Siciliano

Publikováno v: Molecular Psychiatry. 28:1585-1598

There is inherent tension between methodologies developed to address basic research questions in model species and those intended for preclinical to clinical translation: basic investigations require flexibility of experimental design as hypotheses a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::197f361a3c2d92bf59cf3a5554d5b766
https://doi.org/10.1038/s41380-023-01994-4

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A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies

Autor: Christina Sanders, Jennifer Tat, Alberto J. López, Jennifer E. Zachry, Amy R. Johnson, Patrick R Melugin, Shannon J. Kelly, Munir Gunes Kutlu, Kimberly C. Thibeault, Lillian J. Brady, Cody A. Siciliano, Erin S. Calipari

Publikováno v: Neuropsychopharmacology

A large body of work has focused on understanding stimulus-driven behavior, sex differences in these processes, and the neural circuits underlying them. Many preclinical mouse models present rewarding or aversive stimuli in isolation, ignoring that e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1d657133bfa66351cbb9e65396586b
https://doi.org/10.1038/s41386-020-0692-1

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Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens

Autor: Patrick R Melugin, Tanner J. Euston, Alberto J. López, Kimberly C. Thibeault, Rashaun S. Wilson, M. Gunes Kutlu, Emily Chuang, Amy R. Johnson, Erin S. Calipari, Shannon J. Kelly, TuKiet T. Lam, Veronika Kondev, Suzanne O. Nolan, Lillian J. Brady, Drew D. Kiraly

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology

Substance use disorder (SUD) is a chronic neuropsychiatric condition characterized by long-lasting alterations in the neural circuitry regulating reward and motivation. Substantial work has focused on characterizing the molecular substrates that unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5029d96ed6ef8d4da5ce95b2d8c843c
https://doi.org/10.1038/s42003-021-02358-w

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Dopamine signaling in the nucleus accumbens core mediates latent inhibition

Autor: Munir Gunes, Kutlu, Jennifer E, Zachry, Patrick R, Melugin, Jennifer, Tat, Stephanie, Cajigas, Atagun U, Isiktas, Dev D, Patel, Cody A, Siciliano, Geoffrey, Schoenbaum, Melissa J, Sharpe, Erin S, Calipari

Publikováno v: Nature neuroscience. 25(8)

Studies investigating the neural mechanisms by which associations between cues and predicted outcomes control behavior often use associative learning frameworks to understand the neural control of behavior. These frameworks do not always account for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59b5d3b7b17d00dfaa61ff78fc3ccf97
https://pubmed.ncbi.nlm.nih.gov/35902648

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The effects of acamprosate on prefrontal cortical function are mimicked by CaCl2 and they are influenced by the history of alcohol exposure

Autor: Patrick R. Melugin, Fei Wu, Crystal Munoz, Aarron Phensy, Grishma Pradhan, Yi Luo, Abraham Nofal, Rohan Manepalli, Sven Kroener

Publikováno v: Neuropharmacology. 212

Alcohol use disorder is associated with functional changes in the medial prefrontal cortex (mPFC), which include altered glutamatergic transmission and deficits in executive functions that contribute to relapse. Acamprosate (calcium-bis N-acetylhomot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada36c1b9b87399f16e1bfac240a7939
https://pubmed.ncbi.nlm.nih.gov/35430241

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Bidirectional causality between addiction and cognitive deficits

Autor: Patrick R Melugin, Suzanne O. Nolan, Cody A. Siciliano

Publikováno v: Int Rev Neurobiol
International Review of Neurobiology ISBN: 9780128203552

Cognitive deficits are highly comorbid with substance use disorders. Deficits span multiple cognitive domains, are associated with disease severity across substance classes, and persist long after cessation of substance use. Furthermore, recovery of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6991e19f73a92e1f8938869c412f39
https://europepmc.org/articles/PMC8566632/

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Influence of Future Possible Selves on Outcome Expectancies, Intended Behavior, and Academic Performance

Autor: Joseph Hernandez, Patrick R Melugin, Michael D. Barnett

Publikováno v: Psychological Reports. 122:2320-2330

The purpose of this study was to investigate whether contact with future possible selves impacts individuals’ outcome expectancies, intended behaviors, and long-term outcomes with regard to academic performance. Specifically, we investigated whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb6b1651f617f525b52c86dfc14cdb7
https://doi.org/10.1177/0033294118806483

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Dopamine release in the nucleus accumbens core signals perceived saliency

Autor: Stephanie A. Cajigas, Patrick R Melugin, Jennifer E. Zachry, Maxime Chevée, Munir Gunes Kutlu, Shannon J. Kelly, Cody A. Siciliano, Lin Tian, Erin S. Calipari, Banu Kutlu

Publikováno v: Current Biology. 31:4748-4761.e8

A large body of work has aimed to define the precise information encoded by dopaminergic projections innervating the nucleus accumbens (NAc). Prevailing models are based on reward prediction error (RPE) theory, in which dopamine updates associations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26aef8320663d6cbc505f41522e66c7d
https://doi.org/10.1016/j.cub.2021.08.052

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