Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Patrick Ple"'
Autor:
Agnese Lupo, Benoît Valot, Estelle Saras, Antoine Drapeau, Marine Robert, Maxime Bour, Marisa Haenni, Patrick Plésiat, Jean-Yves Madec, Anaïs Potron
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The Acinetobacter baumannii clonal lineage ST25 has been identified in humans and animals and found associated with outbreaks globally. To highlight possible similarities among ST25 A. baumannii of animal and human origins and to gather clue
Externí odkaz:
https://doaj.org/article/e998585838924625a09bbef765f98f82
Autor:
Alexandre Elabbadi, Stéphane Pont, Charlotte Verdet, Patrick Plésiat, François Cretin, Guillaume Voiriot, Muriel Fartoukh, Michel Djibré
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 53, Iss 4, Pp 647-651 (2020)
Community-acquired Pseudomonas aeruginosa infections are rare. Most cases involve patients either with underlying immunosuppression or structural chronic lung diseases. We report here an atypical case of a severe community-acquired invasive infection
Externí odkaz:
https://doaj.org/article/17cd33ce1c4a4b99932b4715f6fe9174
Autor:
Céline Lucchetti-Miganeh, David Redelberger, Gaël Chambonnier, François Rechenmann, Sylvie Elsen, Christophe Bordi, Katy Jeannot, Ina Attrée, Patrick Plésiat, Sophie de Bentzmann
Publikováno v:
Pathogens, Vol 3, Iss 2, Pp 309-340 (2014)
Pseudomonas aeruginosa is a Gram-negative environmental species and an opportunistic microorganism, establishing itself in vulnerable patients, such as those with cystic fibrosis (CF) or those hospitalized in intensive care units (ICU). It has become
Externí odkaz:
https://doaj.org/article/0764aa8f26ee4098bab68b93c7392284
Autor:
Mohamed H. Al-Agamy, Katy Jeannot, Taghrid S. El-Mahdy, Hassan A. Samaha, Atef M. Shibl, Patrick Plésiat, Patrice Courvalin
Publikováno v:
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 2016 (2016)
Background. This study described various molecular and epidemiological characters determining antibiotic resistance patterns in Pseudomonas aeruginosa isolates. Methods. A total of 34 carbapenem-resistant P. aeruginosa clinical isolates were isolated
Externí odkaz:
https://doaj.org/article/4e24dfa2cc874cda85faf09ae23c2329
Autor:
Sophie de Bentzmann, Caroline Giraud, Christophe S. Bernard, Virginie Calderon, Friederike Ewald, Patrick Plésiat, Cathy Nguyen, Didier Grunwald, Ina Attree, Katy Jeannot, Marie-Odile Fauvarque, Christophe Bordi
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12 (2012)
Externí odkaz:
https://doaj.org/article/8fce0513533d4553b01fd49fd916deb8
Autor:
Christine Lambert-van der Brempt, Jean-Jacques Marcel Lohmann, Twana Saleh, Sébastien L. Degorce, Stephen Green, Rémy Morgentin, Lara Ward, Urs Hancox, Mickaël Maudet, Martina Fitzek, Barlaam Bernard Christophe, Sabina Cosulich, Patrick Ple, Nicolas Warin, Aurélien Péru
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2318-2323
We report the discovery and optimisation of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides, leading to compound 16 as a potent and selective PI3Kβ/δ inhibitor: PI3Kβ cell IC50 0.012 μM (in PTEN nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c86409d445b8e16d247fcaa77b77b0
https://doi.org/10.1016/j.bmcl.2016.03.034
https://doi.org/10.1016/j.bmcl.2016.03.034
Autor:
Sébastien L. Degorce, Patrick Ple, Mickaël Maudet, Jennifer H. Pink, Rowena Callis, Andrew Bailey, Bryan Roberts, Chris De Savi, Richard A. Norman, Rémy Morgentin, Aurélien Péru, Richard Ducray, Scott W. Martin, James S. Scott, Gillian M. Lamont, Philip A. MacFaul
Publikováno v:
Journal of Medicinal Chemistry. 58:3522-3533
A novel estrogen receptor down-regulator, 7-hydroxycoumarin (5, SS5020), has been reported with antitumor effects against chemically induced mammary tumors. Here, we report on our own investigation of 7-hydroxycoumarins as potential selective estroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf5b93b8829793733bb4777a0f071a4
https://doi.org/10.1021/acs.jmedchem.5b00066
https://doi.org/10.1021/acs.jmedchem.5b00066
Autor:
Stephen Green, Sébastien L. Degorce, Sabina Cosulich, Martina Fitzek, Michel Vautier, Christine Lambert-van der Brempt, Lara Ward, Jean-Jacques Marcel Lohmann, Patrick Ple, Barlaam Bernard Christophe, Marie-Jeanne Pasquet, Rémy Morgentin, Michael A. Walker, Twana Saleh, Nicolas Warin, Aurélien Péru, Urs Hancox, Mickaël Maudet
Publikováno v:
Journal of Medicinal Chemistry. 58:943-962
Several studies have highlighted the dependency of PTEN deficient tumors to PI3Kβ activity and specific inhibition of PI3Kδ has been shown activity against human B-cell cancers. We describe the discovery and optimization of a series of 8-(1-anilino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374fddcd264180d79fb9424642feb5b5
https://doi.org/10.1021/jm501629p
https://doi.org/10.1021/jm501629p
Autor:
Rémy Morgentin, Martina Fitzek, Christine Lambert-van der Brempt, Stephen Green, Sébastien L. Degorce, Sabina Cosulich, Mickaël Maudet, Rebecca Ellston, Jean-Jacques Marcel Lohmann, Nicolas Warin, Urs Hancox, Patrick Ple, Lara Ward, Barlaam Bernard Christophe
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(9)
Attempts to lock the active conformation of compound 4, a PI3Kβ/δ inhibitor (PI3Kβ cell IC50 0.015 μM), led to the discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-ones, which showed high levels of pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1de19b5eb37f50e9906170d950d264
https://pubmed.ncbi.nlm.nih.gov/28347666
https://pubmed.ncbi.nlm.nih.gov/28347666
Autor:
Christine Lambert-van der Brempt, Barlaam Bernard Christophe, Sabina Cosulich, Lara Ward, Twana Saleh, Martina Fitzek, Fabrizio Giordanetto, Rémy Morgentin, Sébastien L. Degorce, Laurent Francois Andre Hennequin, Tord Inghardt, Urs Hancox, Patrick Ple, Sarah L. Pass, Stephen Green
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3928-3935
Starting from TGX-221, we designed a series of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as potent and selective PI3Kβ/δ inhibitors. Structure–activity relationships and structure–property relationships around
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2957a67f99262704df92803e1f7edd0d
https://doi.org/10.1016/j.bmcl.2014.06.040
https://doi.org/10.1016/j.bmcl.2014.06.040