Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Patrick P. Humphrey"'
Autor:
Paul R. Fatheree, Jacqueline A.M. Smith, Patrick P. Humphrey, David Beattie, S. Derek Turner, Seok-Ki Choi, Roland Gendron, Daniel Marquess, Goldblum Adam A, Ross G. Vickery, Jeng Pyng Shaw, Scott R. Armstrong, Daniel D. Long, Lan Jiang, Daniel Genov
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(19)
Utilization of Theravance’s multivalent approach to drug discovery towards 5-HT 4 receptor agonists with a focus on identification of neutral (non-charged at physiological pH) secondary binding groups is described. Optimization of a quinolone-tropa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dc3bfd1562242be0ff583154f8c9fe
https://pubmed.ncbi.nlm.nih.gov/22959244
https://pubmed.ncbi.nlm.nih.gov/22959244
Autor:
David Beattie, Daniel D. Long, S. Derek Turner, Paul R. Fatheree, Jacqueline A.M. Smith, Scott R. Armstrong, Seok-Ki Choi, Roland Gendron, Jeng Pyng Shaw, Goldblum Adam A, Daniel Marquess, Ross G. Vickery, Patrick P. Humphrey
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
Further application of our multivalent approach to drug discovery directed to 5-HT4 receptor agonists is described. Optimization of the linker and secondary binding amine in the indazole-tropane primary binding group series, for binding affinity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d91c6df1bb3ebe20770d405356021a
https://pubmed.ncbi.nlm.nih.gov/22683222
https://pubmed.ncbi.nlm.nih.gov/22683222
Autor:
Stacey R. Lewis, Kevin M. Krause, Alfred Dieudonné Kinana, James W. Janc, Johanne Blais, Patrick P. Humphrey, Bret M. Benton, Craig M. Hill, Mathai Mammen
Publikováno v:
Antimicrobial agents and chemotherapy. 54(7)
Telavancin is a bactericidal, semisynthetic lipoglycopeptide indicated in the United States for the treatment of complicated skin and skin structure infections caused by susceptible Gram-positive bacteria and is under investigation as a once-daily tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d363edf402941d264884cb0141c403
https://pubmed.ncbi.nlm.nih.gov/20404117
https://pubmed.ncbi.nlm.nih.gov/20404117
Autor:
Scott R. Armstrong, Seok-Ki Choi, Jeng-Pyng Shaw, David Beattie, Goldblum Adam A, S. Derek Turner, Daniel D. Long, R. Murray McKinnell, Ross G. Vickery, Daniel Marquess, Paul R. Fatheree, Jacqueline A.M. Smith, Roland Gendron, Patrick P. Humphrey
Publikováno v:
Journal of medicinal chemistry. 52(17)
5-HT(4) receptor agonists such as tegaserod have demonstrated efficacy in the treatment of constipation predominant irritable bowel syndrome (IBS-C), a highly prevalent disorder characterized by chronic constipation and impairment of intestinal propu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4688cb8658e9c717a833552ee059467
https://pubmed.ncbi.nlm.nih.gov/19663444
https://pubmed.ncbi.nlm.nih.gov/19663444
Autor:
Bret M. Benton, Mathai Mammen, Christopher S. Lunde, Stephanie R. Hartouni, James W. Janc, Patrick P. Humphrey
Publikováno v:
Antimicrobial agents and chemotherapy. 53(8)
Telavancin is an investigational lipoglycopeptide antibiotic currently being developed for the treatment of serious infections caused by gram-positive bacteria. The bactericidal action of telavancin results from a mechanism that combines the inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f5b51fa600afd043e43dd91c668fd7
https://pubmed.ncbi.nlm.nih.gov/20210546
https://pubmed.ncbi.nlm.nih.gov/20210546
Autor:
Qiufeng Gao, Jeffrey M. Hubbard, Terry Wu, Joey Leung, Donald E. Schmidt, Robert T. Cass, Koné Kaniga, Dane E. Karr, Patrick P. Humphrey, Deborah L. Higgins, Erik Sandvik, Kevin M. Krause, Bret M. Benton, Dmitri Debabov, Ray Chang
Publikováno v:
Antimicrobial agents and chemotherapy. 49(3)
The emergence and spread of multidrug-resistant gram-positive bacteria represent a serious clinical problem. Telavancin is a novel lipoglycopeptide antibiotic that possesses rapid in vitro bactericidal activity against a broad spectrum of clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8345b0eb3746c9bbf1cf5eb1e291d339
https://pubmed.ncbi.nlm.nih.gov/15728913
https://pubmed.ncbi.nlm.nih.gov/15728913
Autor:
R. Murray McKinnell, Scott R. Armstrong, David T. Beattie, Seok-Ki Choi, Paul R. Fatheree, Roland A. L. Gendron, Adam Goldblum, Patrick P. Humphrey, Daniel D. Long, Daniel G. Marquess, J. P. Shaw, Jacqueline A. M. Smith, S. Derek Turner, Ross G. Vickery
Publikováno v:
Journal of Medicinal Chemistry; Sep2009, Vol. 52 Issue 17, p5330-5343, 14p
Autor:
Page C; Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK., Humphrey P
Publikováno v:
British journal of clinical pharmacology [Br J Clin Pharmacol] 2013 May; Vol. 75 (5), pp. 1213-8.