Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Patrick O. McGowan"'
Autor:
Mouly F. Rahman, Patrick O. McGowan
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Early life stress (ELS) induces long-term phenotypic adaptations that contribute to increased vulnerability to a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNA,
Externí odkaz:
https://doaj.org/article/38a85512655749f8a672ea0f04048a87
Hippocampus-Anterior Hypothalamic Circuit Modulates Stress-Induced Endocrine and Behavioral Response
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
Hippocampal input to the hypothalamus is known to be critically involved in mediating the negative feedback inhibition of stress response. However, the underlying neural circuitry has not been fully elucidated. Using a combination of rabies tracing,
Externí odkaz:
https://doaj.org/article/921ddbcb98d94852beb8f2e435d3aa48
Autor:
Sanoji Wijenayake, Mouly F. Rahman, Christine M. W. Lum, Wilfred C. De Vega, Aya Sasaki, Patrick O. McGowan
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Maternal obesity as a result of high levels of saturated fat (HFD) consumption leads to significant negative health outcomes in both mother and exposed offspring. Offspring exposed to maternal HFD show sex-specific alterations in
Externí odkaz:
https://doaj.org/article/6920bb20f80146d4884153e44bce3d22
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Maternal obesity is an important risk factor for childhood obesity and influences the prevalence of metabolic diseases in offspring. As childhood obesity is influenced by postnatal factors, it is critical to determine whether children born to women w
Externí odkaz:
https://doaj.org/article/1eedc869093d4e86b7ddc53a1cecf69e
Publikováno v:
Epigenetics, Vol 13, Iss 12, Pp 1174-1190 (2018)
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease of unknown etiology. Multiple studies point to disruptions in immune functioning in ME/CFS patients as well as specific genetic polymorphisms and alterations of the DNA
Externí odkaz:
https://doaj.org/article/4dcd742e79c741a085ae1c5f575526e1
Autor:
Samantha C. Lauby, David G. Ashbrook, Hannan R. Malik, Diptendu Chatterjee, Pauline Pan, Alison S. Fleming, Patrick O. McGowan
Publikováno v:
Brain and Behavior, Vol 11, Iss 4, Pp n/a-n/a (2021)
Abstract Introduction Rat mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that could influence this propagation. Methods We assessed early
Externí odkaz:
https://doaj.org/article/5b06931bbde74ab5b0037b6019642948
Autor:
David G. Ashbrook, Benjamin Hing, Lindsay T. Michalovicz, Kimberly A. Kelly, Julie V. Miller, Wilfred C. de Vega, Diane B. Miller, Gordon Broderick, James P. O’Callaghan, Patrick O. McGowan
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Background Gulf War illness (GWI) is an archetypal, medically unexplained, chronic condition characterised by persistent sickness behaviour and neuroimmune and neuroinflammatory components. An estimated 25–32% of the over 900,000 veterans
Externí odkaz:
https://doaj.org/article/9f39f5e4e53b46adb76bbf40088222b8
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Maternal stress has a profound impact on the long-term behavioral phenotype of offspring, including behavioral responses to stressful and social situations. In this study, we examined the effects of maternal exposure to predator odor, an ethologicall
Externí odkaz:
https://doaj.org/article/f08bfc437d494f98ad9b48fe39b94f14
Autor:
Patrick O. McGowan, Moshe Szyf
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 1, Pp 66-72 (2010)
An organism's behavioral and physiological and social milieu influence and are influenced by the epigenome, which is composed predominantly of chromatin and the covalent modification of DNA by methylation. Epigenetic patterns are sculpted during deve
Externí odkaz:
https://doaj.org/article/0d7b61e204e64f6f9b3865d79b1767cd
Publikováno v:
Journal of Developmental Origins of Health and Disease. 13:665-673
Lactation is a critical time in mammalian development, where maternal factors shape offspring outcomes. In this scoping review, we discuss current literature concerning maternal factors that influence lactation biology and highlight important associa