Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Patrick O Humbert"'
Autor:
Julia Hatzold, Verena Nett, Stephanie Brantsch, Jin-Li Zhang, Joy Armistead, Heike Wessendorf, Rebecca Stephens, Patrick O Humbert, Sandra Iden, Matthias Hammerschmidt
Publikováno v:
PLoS Genetics, Vol 19, Iss 8, p e1010873 (2023)
Aberrantly up-regulated activity of the type II transmembrane protease Matriptase-1 has been associated with the development and progression of a range of epithelial-derived carcinomas, and a variety of signaling pathways can mediate Matriptase-depen
Externí odkaz:
https://doaj.org/article/72c70ea8bcc5480abbe1bc7b312005cd
Autor:
Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Xia Cuiping, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane J F Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007688 (2018)
Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in v
Externí odkaz:
https://doaj.org/article/398b05ace50540ebbc5d12234222f441
Autor:
Christina B Wölwer, Nathan Gödde, Luke B Pase, Imogen A Elsum, Krystle Y B Lim, Faruk Sacirbegovic, Carl R Walkley, Sarah Ellis, Shigeo Ohno, Fumio Matsuzaki, Sarah M Russell, Patrick O Humbert
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170295 (2017)
Erythroid enucleation is the process by which the future red blood cell disposes of its nucleus prior to entering the blood stream. This key event during red blood cell development has been likened to an asymmetric cell division (ACD), by which the e
Externí odkaz:
https://doaj.org/article/43b59eeb3ede421f8ae99d8004afa19b
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146201 (2016)
Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show th
Externí odkaz:
https://doaj.org/article/3d9578e7d6d54703a1bf6917ce307509
The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
Autor:
Andrew A Jarjour, Amanda Boyd, Lukas E Dow, Rebecca K Holloway, Sandra Goebbels, Patrick O Humbert, Anna Williams, Charles ffrench-Constant
Publikováno v:
PLoS Biology, Vol 13, Iss 3, p e1002107 (2015)
The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requires profound changes in cell shape that lead to myelin sheath initiation and formation. Here, we demonstrate a requirem
Externí odkaz:
https://doaj.org/article/66807c3dc1214268828929b4e77180c2
Autor:
Christina B Wölwer, Luke B Pase, Helen B Pearson, Nathan J Gödde, Kurt Lackovic, David C S Huang, Sarah M Russell, Patrick O Humbert
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142655 (2015)
Erythroid enucleation is critical for terminal differentiation of red blood cells, and involves extrusion of the nucleus by orthochromatic erythroblasts to produce reticulocytes. Due to the difficulty of synchronizing erythroblasts, the molecular mec
Externí odkaz:
https://doaj.org/article/8f9a9667a206456992fa2baa9f936e6b
Autor:
Tia DiTommaso, Denny L Cottle, Helen B Pearson, Holger Schlüter, Pritinder Kaur, Patrick O Humbert, Ian M Smyth
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004706 (2014)
Keratins are cytoskeletal intermediate filament proteins that are increasingly being recognised for their diverse cellular functions. Here we report the consequences of germ line inactivation of Keratin 76 (Krt76) in mice. Homozygous disruption of th
Externí odkaz:
https://doaj.org/article/8f10fdad58e248f49215c890e550eb36
Autor:
Nathan J Godde, Julie M Sheridan, Lorey K Smith, Helen B Pearson, Kara L Britt, Ryan C Galea, Laura L Yates, Jane E Visvader, Patrick O Humbert
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004323 (2014)
Polarity coordinates cell movement, differentiation, proliferation and apoptosis to build and maintain complex epithelial tissues such as the mammary gland. Loss of polarity and the deregulation of these processes are critical events in malignant pro
Externí odkaz:
https://doaj.org/article/4654c8576bb2422e842ccdba989b01a7
Autor:
Edwin D Hawkins, Jane Oliaro, Kelly M Ramsbottom, Stephen B Ting, Faruk Sacirbegovic, Michael Harvey, Tanja Kinwell, Jacques Ghysdael, Ricky W Johnstone, Patrick O Humbert, Sarah M Russell
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87376 (2014)
In epithelial and stem cells, lethal giant larvae (Lgl) is a potent tumour suppressor, a regulator of Notch signalling, and a mediator of cell fate via asymmetric cell division. Recent evidence suggests that the function of Lgl is conserved in mammal
Externí odkaz:
https://doaj.org/article/21030384c0c046c3b08fa7383b62b3dc
Autor:
Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45276 (2012)
The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell receptor (TCR) engagement has been implicated in the modulation of T cell development and effector responses. In siRNA-based studies Dlg1,
Externí odkaz:
https://doaj.org/article/5159c08438b74cfcb4ab902da3231388