Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Patrick O Humbert"'
Autor:
Eva-Maria Thüring, Christian Hartmann, Janesha C. Maddumage, Airah Javorsky, Birgitta E. Michels, Volker Gerke, Lawrence Banks, Patrick O. Humbert, Marc Kvansakul, Klaus Ebnet
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat and PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed apical-basal polarity and tumor formation. The tumor-suppre
Externí odkaz:
https://doaj.org/article/1f98da77c25844a090ea916faeec5541
Autor:
Julia Hatzold, Verena Nett, Stephanie Brantsch, Jin-Li Zhang, Joy Armistead, Heike Wessendorf, Rebecca Stephens, Patrick O Humbert, Sandra Iden, Matthias Hammerschmidt
Publikováno v:
PLoS Genetics, Vol 19, Iss 8, p e1010873 (2023)
Aberrantly up-regulated activity of the type II transmembrane protease Matriptase-1 has been associated with the development and progression of a range of epithelial-derived carcinomas, and a variety of signaling pathways can mediate Matriptase-depen
Externí odkaz:
https://doaj.org/article/72c70ea8bcc5480abbe1bc7b312005cd
Autor:
John E. La Marca, Robert W. Ely, Sarah T. Diepstraten, Peter Burke, Gemma L. Kelly, Patrick O. Humbert, Helena E. Richardson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/e9522fc36290440fb2985f54b8531064
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The innovation of multicellularity has driven the unparalleled evolution of animals (Metazoa). But how is a multicellular organism formed and how is its architecture maintained faithfully? The defining properties and rules required for the establishm
Externí odkaz:
https://doaj.org/article/194caa0174e543c08c6c588319f26467
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Airah Javorsky et al. present the crystal structures of SARS-CoV-1 and SARS-CoV-2 E proteins in complex with the PALS1 PDZ domain. Their results suggest that the coronavirus E protein can interfere with normal PALS1 binding, potentially disrupting ep
Externí odkaz:
https://doaj.org/article/01e145d634fb42a783e337f538813dee
Publikováno v:
Viruses, Vol 14, Iss 3, p 583 (2022)
Scribble is a highly conserved regulator of cell polarity, a process that enables the generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in concert with Disc-large (Dlg) and Lethal-2-giant larvae (Lgl) to form
Externí odkaz:
https://doaj.org/article/9c220240c4d1405fa91b1c26224cdde1
Publikováno v:
Biochemical Society Transactions. 51:415-426
Scribble is a scaffolding protein that regulates key events such as cell polarity, tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise of 16 Leucine Rich Repeats (LRR) at the N-terminus, two LAP Specific Domains (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23485b039b3adfe6e55579ad23b77b80
https://doi.org/10.1042/bst20221067
https://doi.org/10.1042/bst20221067
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplementary Figure 7: Characterization of Pik3ca+/HR, Ptenfl/fl and Pik3ca+/HR;Ptenfl/fl prostate tumors. Representative images of IHC to detect (A) PCNA and (B) Cleaved-caspase 3 (CC3) in Pik3ca+/HR, Ptenfl/fl and Pik3ca+/HR;Ptenfl/fl prostate tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3488fe8b07def2dceebd43715c46b34f
https://doi.org/10.1158/2159-8290.22532960
https://doi.org/10.1158/2159-8290.22532960
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplemetary Material and Tables S1 - S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578fd7c7f0304b17bda6ca3fb1f6dbfd
https://doi.org/10.1158/2159-8290.22532957
https://doi.org/10.1158/2159-8290.22532957
Supplementary Materials and Methods from Transcriptional Output of the Salvador/Warts/Hippo Pathway Is Controlled in Distinct Fashions in Drosophila melanogaster and Mammalian Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4cb27f37860bb644bf254037105f6d
https://doi.org/10.1158/0008-5472.22379508.v1
https://doi.org/10.1158/0008-5472.22379508.v1