Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Patrick O Byrne"'
Autor:
Tessa N Cressey, Afzaal M Shareef, Victoria A Kleiner, Sarah L Noton, Patrick O Byrne, Jason S McLellan, Elke Mühlberger, Rachel Fearns
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010451 (2022)
De novo initiation by viral RNA-dependent RNA polymerases often requires a polymerase priming residue, located within a priming loop, to stabilize the initiating NTPs. Polymerase structures from three different non-segmented negative strand RNA virus
Externí odkaz:
https://doaj.org/article/0a13506617e34b1f876b02efa62ecf13
Autor:
Jennifer M Kavran, Jacqueline M McCabe, Patrick O Byrne, Mary Katherine Connacher, Zhihong Wang, Alexander Ramek, Sarvenaz Sarabipour, Yibing Shan, David E Shaw, Kalina Hristova, Philip A Cole, Daniel J Leahy
Publikováno v:
eLife, Vol 3 (2014)
The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear. We poi
Externí odkaz:
https://doaj.org/article/3afe172341a44b0e9531fe01009e541c
Autor:
Patrick O. Byrne, Brian E. Fisher, David R. Ambrozak, Elizabeth G. Blade, Yaroslav Tsybovsky, Barney S. Graham, Jason S. McLellan, Rebecca J. Loomis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Henipaviruses such as Nipah virus (NiV) cause severe encephalitis with high fatality rates in humans. NiV fusion (F) glycoprotein is a key target of the host immune response. Here, Byrne et al. isolate ten neutralizing antibodies against NiV prefusio
Externí odkaz:
https://doaj.org/article/496b231ac59e4e758d2a99f1801b371b
Autor:
Matthew R. Chang, Luke Tomasovic, Natalia A. Kuzmina, Adam J. Ronk, Patrick O. Byrne, Rebecca Johnson, Nadia Storm, Eduardo Olmedillas, Yixuan J. Hou, Alexandra Schäfer, Sarah R. Leist, Longping V. Tse, Hanzhong Ke, Christian Coherd, Katrina Nguyen, Maliwan Kamkaew, Anna Honko, Quan Zhu, Galit Alter, Erica Ollmann Saphire, Jason S. McLellan, Anthony Griffiths, Ralph S. Baric, Alexander Bukreyev, Wayne A. Marasco
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
COVID-19 can be treated with monoclonal antibodies against SARS-CoV-2, but emerging new variants might show resistance towards existing therapy. Here authors show that anti-SARS-CoV-2 spike human single-chain antibody fragments could gain neutralizin
Externí odkaz:
https://doaj.org/article/d418ec52ee6b432581629e7a51ee58b4
Autor:
Foteini Bartzoka, Monica Gonzalez-Magaldi, Patrick O. Byrne, Nicole I. Callery, Kalina Hristova, Daniel J. Leahy
The Epidermal Growth Factor Receptor (EGFR) is a Receptor Tyrosine Kinase that mediates cell proliferation and differentiation events during development and maintenance of complex organisms. Formation of specific, ligand-dependent EGFR dimers is a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce74772520e9011d0140a0b26690fa5
https://doi.org/10.1101/2022.09.08.507182
https://doi.org/10.1101/2022.09.08.507182
Autor:
Patrick O. Byrne, Brian E. Fisher, David R. Ambrozak, Elizabeth G. Blade, Yaroslav Tsybovsky, Barney S. Graham, Jason S. McLellan, Rebecca J. Loomis
Nipah virus (NiV) is a pathogenic paramyxovirus that causes fatal encephalitis in humans. Two envelope glycoproteins, the attachment protein (G/RBP) and fusion protein (F), facilitate entry into host cells. Due to its vital role, NiV F presents an at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0001673fcd30972889720e8c29325c1f
https://doi.org/10.1101/2022.06.13.495706
https://doi.org/10.1101/2022.06.13.495706
Autor:
Tessa N. Cressey, Afzaal M. Shareef, Victoria A. Kleiner, Sarah L. Noton, Patrick O. Byrne, Jason S. McLellan, Elke Mühlberger, Rachel Fearns
De novo initiation by viral RNA-dependent RNA polymerases often requires a polymerase priming residue, located within a priming loop, to stabilize the initiating NTPs. Polymerase structures from three different non-segmented negative strand RNA virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa55a115356ff51185fdaa1e2b7fa11
https://doi.org/10.1101/2022.03.18.484858
https://doi.org/10.1101/2022.03.18.484858
Publikováno v:
J Biol Chem
The human epidermal growth factor receptor (EGFR/ERBB1) is a receptor tyrosine kinase (RTK) that forms activated oligomers in response to ligand. Much evidence indicates that EGFR/ERBB1 also forms oligomers in the absence of ligand, but the structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf6c4f57023b02a5a94668fb34cd6e2
https://doi.org/10.1074/jbc.ra120.012852
https://doi.org/10.1074/jbc.ra120.012852
Autor:
Patrick O Byrne, Jason S McLellan
Publikováno v:
Current opinion in immunology. 77
Viral proteins fold into a variety of structures as they perform their functions. Structure-based vaccine design aims to exploit knowledge of an antigen's architecture to stabilize it in a vulnerable conformation. We summarize the general principles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a264fcead65f24bc1d469de3d31c9802
https://pubmed.ncbi.nlm.nih.gov/35598506
https://pubmed.ncbi.nlm.nih.gov/35598506
Autor:
Jean Daniel Jacob, Patrick OʼByrne
Publikováno v:
Advances in Nursing Science. 42:E1-E10
HIV prevention has changed since the identification of AIDS in 1981, the discovery of HIV in 1983, and the rollout of HIV antibody testing in 1985. Since this time, HIV prevention changed from behavior modification to testing to treatment as preventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b22f790555175d1457a85040d976cc
https://doi.org/10.1097/ans.0000000000000268
https://doi.org/10.1097/ans.0000000000000268