Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Patrick O, Helmer"'
Autor:
Bastian Blume, Vera Schwantes, Michael Witting, Heiko Hayen, Philippe Schmitt-Kopplin, Patrick O. Helmer, Bernhard Michalke
Publikováno v:
Journal of Proteome Research. 22:837-850
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
Autor:
Marta Palomo-Guerrero, Rut Fadó, Maria Casas, Marta Pérez-Montero, Miguel Baena, Patrick O Helmer, José Luis Domínguez, Aina Roig, Dolors Serra, Heiko Hayen, Harald Stenmark, Camilla Raiborg, Núria Casals
Publikováno v:
eLife, Vol 8 (2019)
Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctua
Externí odkaz:
https://doaj.org/article/3271027ebcbb4e948ef1a81bd8c4e174
Autor:
Robin Schmid, Steffen Heuckeroth, Ansgar Korf, Aleksandr Smirnov, Owen Myers, Thomas S. Dyrlund, Roman Bushuiev, Kevin J. Murray, Nils Hoffmann, Miaoshan Lu, Abinesh Sarvepalli, Zheng Zhang, Markus Fleischauer, Kai Dührkop, Mark Wesner, Shawn J. Hoogstra, Edward Rudt, Olena Mokshyna, Corinna Brungs, Kirill Ponomarov, Lana Mutabdžija, Tito Damiani, Chris J. Pudney, Mark Earll, Patrick O. Helmer, Timothy R. Fallon, Tobias Schulze, Albert Rivas-Ubach, Aivett Bilbao, Henning Richter, Louis-Félix Nothias, Mingxun Wang, Matej Orešič, Jing-Ke Weng, Sebastian Böcker, Astrid Jeibmann, Heiko Hayen, Uwe Karst, Pieter C. Dorrestein, Daniel Petras, Xiuxia Du, Tomáš Pluskal
Publikováno v:
Nature Biotechnology. 41:447-449
Autor:
Rebecca Buchholz, Florian Zubeil, Ansgar Korf, Uwe Karst, Arne Behrens, Heiko Hayen, Patrick O. Helmer, Ilona D Nordhorn
Publikováno v:
Analytical Chemistry. 93:2135-2143
Lipids, such for example the multifaceted category of glycerophospholipids (GP), play a major role in many biological processes. High-resolution mass spectrometry is able to identify these highly diverse lipid species in combination with fragmentatio
Publikováno v:
Free Radical Biology and Medicine. 162:216-224
The investigation of neurodegenerative and age-related diseases is a highly relevant topic in current research. Especially oxidative stress is thought to be the common underlying mechanism in diseases such as Parkinson's or Alzheimer's disease. The n
Publikováno v:
Analytical Chemistry. 92:12010-12016
In recent years, cardiolipin (CL) oxidation products were recognized as potential markers for mitochondrial dysfunction in conjunction with age related diseases. The analysis of oxidized CL requires powerful analysis techniques due to high structural
Publikováno v:
Rapid Communications in Mass Spectrometry. 34
RATIONALE Lipid A is a part of the lipopolysaccharide layer, which is a main component of the outer membrane from Gram-negative bacteria. It can be sensed by mammalians to identify the presence of Gram-negative bacteria in their tissues and plays a k
Publikováno v:
Rapid communications in mass spectrometry : RCMREFERENCES. 34(21)
Lipid A is a part of the lipopolysaccharide layer, which is a main component of the outer membrane from Gram-negative bacteria. It can be sensed by mammalians to identify the presence of Gram-negative bacteria in their tissues and plays a key role in
Publikováno v:
Rapid Communications in Mass Spectrometry. 34
Rationale Cardiolipins (CL) are a special lipid class which plays a main role in energy metabolism in mitochondria and is involved in apoptosis. In contrast to other glycerophospholipids, they contain four fatty acyl residues which results in a high
Publikováno v:
Journal of chromatography. A. 1619
The anionic phospholipid class of cardiolipins (CL) is increasingly attracting scientific attention in the recent years. CL can be found as a functional component of mitochondrial membranes in almost all living organisms. Changes in the CL compositio