Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Patrick Niekamp"'
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114200- (2024)
Summary: Innate lymphoid cells (ILCs), strategically positioned throughout the body, undergo population declines over time. A solution to counteract this problem is timely mobilization of multipotential progenitors from the bone marrow. It remains un
Externí odkaz:
https://doaj.org/article/7914fce651a24ac49124e29b891efd73
Autor:
Patrick Niekamp, Chang H. Kim
Publikováno v:
Gut and Liver, Vol 17, Iss 2, Pp 190-203 (2023)
The global burden of colorectal cancer (CRC) is expected to continuously increase. Through research performed in the past decades, the effects of various environmental factors on CRC development have been well identified. Diet, the gut microbiota and
Externí odkaz:
https://doaj.org/article/3d5feb7f397347c79ced7ca1af605932
Autor:
Patrick Niekamp, Felix Scharte, Tolulope Sokoya, Laura Vittadello, Yeongho Kim, Yongqiang Deng, Elisabeth Südhoff, Angelika Hilderink, Mirco Imlau, Christopher J. Clarke, Michael Hensel, Christopher G. Burd, Joost C. M. Holthuis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Activation of ESCRT prevents potentially lethal outcomes of minor perturbations in lysosomal integrity. Here authors show that Ca2 + -activated scrambling of sphingomyelin and its cytosolic turnover drives lysosomal repair independently of ESCRT.
Externí odkaz:
https://doaj.org/article/8782aaf4d7804bac8f2c73df7fa64a62
Autor:
Shashank Dadsena, Svenja Bockelmann, John G. M. Mina, Dina G. Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar Müller, Markus Schneider, Fikadu G. Tafesse, Siewert J. Marrink, Manuel N. Melo, Joost C. M. Holthuis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to ident
Externí odkaz:
https://doaj.org/article/161032635f8246f6afb463a1fd58d74b
Autor:
Patrick Niekamp, Gaelen Guzman, Hans C. Leier, Ali Rashidfarrokhi, Veronica Richina, Fabian Pott, Caroline Barisch, Joost C. M. Holthuis, Fikadu G. Tafesse
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Mycobacterium tuberculosisMtbMtb
Externí odkaz:
https://doaj.org/article/c10c9624a5e94da0b3613b77643ff8dc
Publikováno v:
Journal of Fungi, Vol 6, Iss 1, p 19 (2020)
Fungal infections remain a global health threat with high morbidity and mortality. The human immune system must, therefore, perpetually defend against invasive fungal infections. Phagocytosis is critical for the clearance of fungal pathogens, as this
Externí odkaz:
https://doaj.org/article/b640fc0d40db461f91b876e2c2275fa1
Autor:
Joost Holthuis, Patrick Niekamp
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae43993fba6d7402bcc18fda6d65d6f0
https://doi.org/10.1096/fasebj.2022.36.s1.0r237
https://doi.org/10.1096/fasebj.2022.36.s1.0r237
Autor:
Patrick, Niekamp, Felix, Scharte, Tolulope, Sokoya, Laura, Vittadello, Yeongho, Kim, Yongqiang, Deng, Elisabeth, Südhoff, Angelika, Hilderink, Mirco, Imlau, Christopher J, Clarke, Michael, Hensel, Christopher G, Burd, Joost C M, Holthuis
Publikováno v:
Nature communications. 13(1)
Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell viability. Here we report that cells exploit a sphingomyelin-based lysosomal repair pathway that ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71b1f73979ae3e2298731237ae1ace5d
https://pubmed.ncbi.nlm.nih.gov/35388011
https://pubmed.ncbi.nlm.nih.gov/35388011
Autor:
Mirco Imlau, Laura Vittadello, Yongqiang Deng, Christopher J. Clarke, Angelika Hilderink, Tolulope Sokoya, Joost C. M. Holthuis, Christopher G. Burd, Patrick Niekamp, Yeongho Kim
Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell viability. Here we report that cells exploit a sphingomyelin-based lysosomal repair pathway that ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0230507bf0b449c8e04253c355aa4ba9
https://doi.org/10.1101/2021.03.12.435146
https://doi.org/10.1101/2021.03.12.435146
Autor:
Hans C. Leier, Fabian Pott, Caroline Barisch, Patrick Niekamp, Fikadu G. Tafesse, Ali Rashidfarrokhi, Veronica Richina, Gaelen Guzman, Joost C. M. Holthuis
Publikováno v:
mBio
mBio, Vol 12, Iss 1 (2021)
mBio, Vol 12, Iss 1 (2021)
Mycobacterium tuberculosis (Mtb) invades alveolar macrophages through phagocytosis to establish infection and cause disease. The molecular mechanisms underlying Mtb entry are still poorly understood.
Phagocytosis by alveolar macrophages is the o
Phagocytosis by alveolar macrophages is the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27076bde441208e0f2b9674b50b92c49
https://pubmed.ncbi.nlm.nih.gov/33500344
https://pubmed.ncbi.nlm.nih.gov/33500344