Výsledky vyhledávání - "Patrick Nasarre"

Akademický článek

ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.

Autor: Takeshi Yoshida, Lanxi Song, Yun Bai, Fumi Kinose, Jiannong Li, Kim C Ohaegbulam, Teresita Muñoz-Antonia, Xiaotao Qu, Steven Eschrich, Hidetaka Uramoto, Fumihiro Tanaka, Patrick Nasarre, Robert M Gemmill, Joëlle Roche, Harry A Drabkin, Eric B Haura

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147344 (2016)

Epithelial-mesenchymal transition (EMT) is one mechanism of acquired resistance to inhibitors of the epidermal growth factor receptor-tyrosine kinases (EGFR-TKIs) in non-small cell lung cancer (NSCLC). The precise mechanisms of EMT-related acquired r

Externí odkaz: https://doaj.org/article/3c458785300d4584b84ebdf4b59582e9

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Akademický článek

Selective Suppression of In Vivo Tumorigenicity by Semaphorin SEMA3F in Lung Cancer Cells

Autor: Sophie Kusy, Patrick Nasarre, Daniel Chan, Vincent Potiron, David Meyronet, Robert M. Gemmill, Bruno Constantin, Harry A. Drabkin, Joëlle Roche

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 5, Pp 457-465 (2005)

Loss of the 3p21.3-encoded semaphorins, SEMA3B and SEMA3F is implicated in lung cancer development. Although both antagonize VEGF binding/response to neuropilin (NRP) receptors, in lung cancer lines,SEMA3F is predominantly expressed and preferentiall

Externí odkaz: https://doaj.org/article/f2df5a74439e46a79d33cca7710ade01

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Akademický článek

Semaphorin SEMA3F Has a Repulsing Activity on Breast Cancer Cells and Inhibits E-Cadherin-Mediated Cell Adhesion

Autor: Patrick Nasarre, Sophie Kusy, Bruno Constantin, Valérie Castellani, Harry A. Drabkin, Dominique Bagnard, Joëlle Roche

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 2, Pp 180-189 (2005)

Previously, we demonstrated that loss of SEMA3F, a secreted semaphorin encoded in 3p21.3, is associated with higher stages in lung cancer and primary tumor cells studied with anti-vascular endothelial growth factor (VEGF) and SEMA3F antibodies. In vi

Externí odkaz: https://doaj.org/article/b50712212a8e4bffb7c8c51980188673

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Akademický článek

Semaphorin SEMA3F and VEGF Have Opposing Effects on Cell Attachment and Spreading

Autor: Patrick Nasarre, Bruno Constantin, Lydie Rouhaud, Thomas Harnois, Guy Raymond, Harry A. Drabkin, Nicolas Bourmeyster, Joëlle Roche

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 1, Pp 83-92 (2003)

SEMA3F, isolated from a 3p21.3 deletion, has antitumor activity in transfected cells, and protein expression correlates with tumor stage and histology. In primary tumors, SEMA3F and VEGF surface staining is inversely correlated. Coupled with SEMA3F a

Externí odkaz: https://doaj.org/article/4726a1d7bf2a460f9ed294b498c8fecd

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Data from Semaphorin SEMA3F Affects Multiple Signaling Pathways in Lung Cancer Cells

Autor: Harry A. Drabkin, Joëlle Roche, Robert M. Gemmill, Hellmut G. Augustin, Jonathan A. Clarhaut, Patrick Nasarre, Girish Sharma, Vincent A. Potiron

Loss of SEMA3F occurs frequently in lung cancer and correlates with advanced stage of disease. We previously reported that SEMA3F blocked tumor formation by H157 lung cancer cells in a rat orthotopic model. This was associated with loss of activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baf750543b7e966eba2df6c595219940
https://doi.org/10.1158/0008-5472.c.6496748

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Data from Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth

Autor: Hellmut G. Augustin, Ulrike Fiedler, Gavin Thurston, Dirk Schadendorf, Carleen Deppermann, Vivien Wolter, Iris Helfrich, Karoline Kruse, Markus Thomas, Patrick Nasarre

The angiopoietin/Tie2 system has been identified as the second vascular-specific receptor tyrosine kinase system controlling vessel assembly, maturation, and quiescence. Angiopoietin-2 (Ang-2) is prominently up-regulated in the host-derived vasculatu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7575486f71cfb03aa44b6a58bd868181
https://doi.org/10.1158/0008-5472.c.6499280.v1

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Data from Neuropilin-2 Is Upregulated in Lung Cancer Cells during TGF-β1–Induced Epithelial–Mesenchymal Transition

Autor: Harry A. Drabkin, Philip H. Howe, Alessandro Lagana, Elizabeth Garrett-Mayer, Christopher Korch, Anna E. Barón, Xian Lu, Joëlle Roche, Vincent A. Potiron, Robert M. Gemmill, Patrick Nasarre

The epithelial–mesenchymal transition (EMT) and its reversal, mesenchymal–epithelial transition (MET), are fundamental processes involved in tumor cell invasion and metastasis. SEMA3F is a secreted semaphorin and tumor suppressor downregulated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c42501d5a0efce50e78dcc62d50e03
https://doi.org/10.1158/0008-5472.c.6504636

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Supplementary Figures 1 - 7 from Neuropilin-2 Is Upregulated in Lung Cancer Cells during TGF-β1–Induced Epithelial–Mesenchymal Transition

Autor: Harry A. Drabkin, Philip H. Howe, Alessandro Lagana, Elizabeth Garrett-Mayer, Christopher Korch, Anna E. Barón, Xian Lu, Joëlle Roche, Vincent A. Potiron, Robert M. Gemmill, Patrick Nasarre

PDF file - 1864K, NRP2 is stably up-regulated by TGFβ in lung cancer cells without increasing the halflife of mRNA or protein (S1); NRP2 up-regulation is blocked by inhibition of TβRI, AKT, ERK and ZEB1, but not by expression of inhibitory SMAD7 (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a2d136b79ea18f701cfa8309630fb8
https://doi.org/10.1158/0008-5472.22396713

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