Výsledky vyhledávání - "Patrick Molina"

Akademický článek

430 Time restricted feeding in diet induced obesity mouse model reduces aortic stiffness and inflammatory T cells

Autor: Claudia Edell, Paramita Pati, Jackson Colson, Patrick Molina, David M Pollock, Jennifer S Pollock

Publikováno v: Journal of Clinical and Translational Science, Vol 6, Pp 84-84 (2022)

OBJECTIVES/GOALS: Time restricted feeding (TRF) in diet induced obesity (DIO) has several health benefits, including improved metabolic rhythms and inflammation. Our lab has shown that TRF in DIO significantly reduces renal and aortic damage. The mai

Externí odkaz: https://doaj.org/article/26526164e412460d91cc9e4f67bd8ca5

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Early life stress in mice leads to impaired colonic corticosterone production and prolonged inflammation following induction of colitis

Autor: Rachel Muir, Barbara Klocke, Melissa Jennings, Patrick Molina, Jung-Shan Hsu, Cailin Kellum, Katie Alexander, Goo Lee, Jeremy Foote, Robin Lorenz, Jennifer Pollock, Craig Maynard

Publikováno v: Physiology. 38

Early life stress (ELS) is an environmental trigger linked to increased risk of inflammatory bowel disease (IBD). Our goal was to identify mechanisms whereby ELS in mice affects susceptibility to, and/or severity of, intestinal inflammation. We hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ea0b7fa65ae2ce5dcaf264968829a4a
https://doi.org/10.1152/physiol.2023.38.s1.5733028

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Abstract 46: Vascular Endothelium-derived Endothelin 1 Promotes Salt-induced Kidney Inflammation In Male But Not Female Mice

Autor: Claudia Edell, Patrick Molina, Jennifer S. Pollock, Sara N Biswal, Carmen De Miguel

Publikováno v: Hypertension. 78

Endothelin 1 (ET-1), potent vasoactive and pro-inflammatory peptide, plays a criticalrole in hypertension and end-organ damage. The inflammatory response to high saltintake displays sex differences; however, if a sex difference exists in vascular ET-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5543873922e7af30a75c2c67532043a
https://doi.org/10.1161/hyp.78.suppl_1.46

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Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice

Autor: David M. Pollock, Luke S Dunaway, Crystal M Taylor, Jennifer S. Pollock, Patrick Molina, Randee Sedaka, Malgorzata Kasztan

Publikováno v: Am J Physiol Regul Integr Comp Physiol

Despite advancements in disease management, sickle cell nephropathy, a major contributor to mortality and morbidity in patients, has limited therapeutic options. Previous studies indicate hydroxyurea, a commonly prescribed therapy for sickle cell dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4ad37c3e672f44060a105a06abffa6
https://pubmed.ncbi.nlm.nih.gov/33624556

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Abstract P063: Pressor Response To Acute Stress Is Regulated By Histamine In Humanized Sickle Cell Mice

Autor: David M. Pollock, Malgorzata Kasztan, Bryan K. Becker, Patrick Molina, Brandon M. Fox, Davide Botta, John Miller Allan, Randee Sedaka, Jennifer S. Pollock

Publikováno v: Hypertension. 76

Acute psychosocial stress has been linked to the onset of vaso-occlusive pain crises in patients with sickle cell disease (SCD), however mechanistic insight is lacking. Studies suggest that histamine is a stress-responsive factor and promotes inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdef1137f47cdf7b562d222d1811c5b5
https://doi.org/10.1161/hyp.76.suppl_1.p063

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Abstract P143: Salt-sensitivity And Salt-resistance Differentially Modulate Renal And Colonic T Regulatory Cells

Autor: Claudia Edell, Rachel Q Muir, Jackson Colson, Patrick Molina, Jennifer S. Pollock, Craig L. Maynard

Publikováno v: Hypertension. 76

High salt diets (HSD) promote both inflammation and immunosuppression as shown in numerous studies utilizing salt-sensitive or hypertensive models. However, mechanisms involved in the homeostatic immune response to HSD, alone, have not been fully elu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37d902b75e4f51f66a058341d3174b5d
https://doi.org/10.1161/hyp.76.suppl_1.p143

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Abstract P1107: Acute Psychosocial Stress Increases Circulating Inflammatory Mediators in the Humanized Sickle Cell Mouse Model

Autor: Davide Botta, Malgorzata Kasztan, Jennifer S. Pollock, Bryan K. Becker, David M. Pollock, Randee Sedaka, J. Miller Allan, Brandon M. Fox, Patrick Molina

Publikováno v: Hypertension. 74

Vaso-occlusive crisis often occurs in sickle cell disease (SCD). Since psychosocial stress leads to impaired vascular function and inflammation, we hypothesized that acute psychosocial stress elicits an exaggerated blood pressure response and/or incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::144d903ad68bd4e02fbfff7a6c0ca236
https://doi.org/10.1161/hyp.74.suppl_1.p1107

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