Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Patrick Ming‐Kuen Tang"'
Autor:
Jane Siu-Fan Li, Philip Chiu-Tsun Tang, Chun Kit K. Choi, Alex Siu-Wing Chan, Calvin Sze-Hang Ng, Ka-Fai To, Patrick Ming-Kuen Tang
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102823- (2024)
Summary: Immunodynamics in the tumor microenvironment can be precisely examined by using multiple antigen identification approaches. Here, we present a protocol for capturing expression levels of multiple target proteins in the same specimen at singl
Externí odkaz:
https://doaj.org/article/cd4afc4f3ab7487fb859f4714d8f1397
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/48fd65e3386b4a07b233854b182e296d
Autor:
Pingchuan Ma, Gaowei Zhang, Su Chen, Cheng Miao, Yubin Cao, Meng Wang, Wenwen Liu, Jiefei Shen, Patrick Ming-Kuen Tang, Yi Men, Li Ye, Chunjie Li
Publikováno v:
International Journal of Oral Science, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Resection of oral and maxillofacial tumors is often accompanied by the inferior alveolar nerve neurectomy, resulting in abnormal sensation in lower lip. It is generally believed that spontaneous sensory recovery in this nerve injury is diffi
Externí odkaz:
https://doaj.org/article/a588c147f1c445f8a45d14c98e6e5a17
Autor:
Philip Chiu‐Tsun Tang, Max Kam‐Kwan Chan, Jeff Yat‐Fai Chung, Alex Siu‐Wing Chan, Dongmei Zhang, Chunjie Li, Kam‐Tong Leung, Calvin Sze‐Hang Ng, Yi Wu, Ka‐Fai To, Hui‐Yao Lan, Patrick Ming‐Kuen Tang
Publikováno v:
Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)
Abstract Macrophage‐myofibroblast transition (MMT) is a newly discovered pathway for mass production of pro‐tumoral cancer‐associated fibroblasts (CAFs) in non‐small cell lung carcinoma (NSCLC) in a TGF‐β1/Smad3 dependent manner. Better un
Externí odkaz:
https://doaj.org/article/87ee915054aa49ad8d44d285ae662e18
Autor:
Max Kam-Kwan Chan, Emily Lok-Yiu Chan, Zoey Zeyuan Ji, Alex Siu-Wing Chan, Chunjie Li, Kam-Tong Leung, Ka-Fai To, Patrick Ming-Kuen Tang
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 2, Pp 316-343 (2023)
Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, b
Externí odkaz:
https://doaj.org/article/f66b695eb39a44d683eec8cd54acc160
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Autor:
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinom
Externí odkaz:
https://doaj.org/article/ba3ca05e7ec94b9aa2d7bbddfdfd4bef
Autor:
Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu, Patrick Ming-Kuen Tang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and anti-cancer activities are reported, including not only angiogenesis, extra
Externí odkaz:
https://doaj.org/article/a52ec436a9d74b35b7278bb97071615b
Autor:
Patrick Ming-Kuen Tang, Dongmei Zhang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16584 (2023)
Drug resistance remains one of the important clinical challenges, making cancer one of the leading causes of death worldwide [...]
Externí odkaz:
https://doaj.org/article/ea44ef1032384240bc796c72826c165a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Fibrotic signaling plays a pivotal role in the development and progression of solid cancers including renal cell carcinoma (RCC). Intratumoral fibrosis (ITF) and pseudo-capsule (PC) fibrosis are significantly correlated to the disease progression of
Externí odkaz:
https://doaj.org/article/7858040124bb4b28ab59dca129ea1f30
Autor:
Vivian Weiwen Xue, Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Travis Hoi-Wai To, Justin Shing-Yin Chung, Francis Mussal, Eric W.-F. Lam, Chunjie Li, Ka-Fai To, Kam-Tong Leung, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 26-37 (2021)
Mincle is essential for tumor-associated macrophage (TAM)-driven cancer progression and represents a potential immunotherapeutic target for cancer. Nevertheless, the lack of a specific inhibitor has largely limited its clinical translation. Here, we
Externí odkaz:
https://doaj.org/article/1ce12fdf1f614834a957f8ffa6de827e