Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Patrick Michael Ann Arbor La Ann Arbor O'brien"'
Autor:
Christie G. Brouillette, Patrick I. McConnell, Patrick Michael Ann Arbor La Ann Arbor O'brien, Matthew H. Parker, Craig Banotai, William T. Mueller, Daniel F. Ortwine, Elizabeth A. Lunney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2427-2430
Isothermal titration calorimetry was used to analyze the binding of an enantiomeric pair of inhibitors to the stromelysin-1 catalytic domain. Differences in binding affinity are attributable to different conformational entropy penalties suffered upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024bcbea62863cbb7c7bc7b7a516cc07
https://doi.org/10.1016/s0960-894x(00)00495-9
https://doi.org/10.1016/s0960-894x(00)00495-9
Autor:
Brandon Collins, W. Howard Roark, Katherine E. Palmquist, Grace E. Munie, Mark E. Schnute, Olga V. Nemirovskiy, Patrick Michael Ann Arbor La Ann Arbor O'brien, Jeffrey A. Scholten, Karl W. Aston, Jeffery N. Carroll, Lillian E. Vickery, T. Sunyer, Steven L. Settle, Joe Nahra, Hanau Cathleen E, Bruce C. Hamper, Peter G. Ruminski, Patt William Chester, Jeffrey Hitchcock, Mark Morris, Huey S. Shieh, Theresa R. Fletcher, Chiu-Fai Man, Joseph J. McDonald, Adam R. Johnson, Michael David Rogers, Arthur J. Wittwer, Alexander Pavlovsky, Richard D. Dyer, Arun Agawal
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
Potent, highly selective and orally-bioavailable MMP-13 inhibitors have been identified based upon a (pyridin-4-yl)-2H-tetrazole scaffold. Co-crystal structure analysis revealed that the inhibitors bind at the S(1)(') active site pocket and are not l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d21a6adaf1297782797ee424c48361
https://pubmed.ncbi.nlm.nih.gov/20005097
https://pubmed.ncbi.nlm.nih.gov/20005097
Autor:
Daniel F. Ortwine, Patrick Michael Ann Arbor La Ann Arbor O'brien, Kenneth S. Kilgore, Adam R. Johnson, Chiu-Fai Man, Vijay Baragi, Joe Nahra, Wen-Song Yue, Amy Mae Bunker, Richard D. Dyer, Hyo-Kyung Han, Jie Jack Li
Publikováno v:
Journal of medicinal chemistry. 51(4)
Quinazolinones 8 and pyrido[3,4-d]pyrimidin-4-ones 9 as orally active and specific matrix metalloproteinase-13 inhibitors were discovered for the treatment of osteoarthritis. Starting from a high-through-put screening (HTS) hit thizolopyrimidin-dione
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc028ae17896d68083573ba5e5811c04
https://pubmed.ncbi.nlm.nih.gov/18251495
https://pubmed.ncbi.nlm.nih.gov/18251495