Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Patrick Man-pan Yuen"'
Autor:
Chi Zhang, Kathy Yuen Yee Chan, Wing Hei Ng, John Tak Kit Cheung, Qiwei Sun, Han Wang, Po Yee Chung, Frankie Wai Tsoi Cheng, Alex Wing Kwan Leung, Xiao-Bing Zhang, Po Yi Lee, Siu Ping Fok, Guanglan Lin, Ellen Ngar Yun Poon, Jian-Hua Feng, Yan-Lai Tang, Xue-Qun Luo, Li-Bin Huang, Wei Kang, Patrick Ming Kuen Tang, Junbin Huang, Chun Chen, Junchao Dong, Ester Mejstrikova, Jiaoyang Cai, Yu Liu, Shuhong Shen, Jun J Yang, Patrick Man Pan Yuen, Chi Kong Li, Kam Tong Leung
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Resistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance co
Externí odkaz:
https://doaj.org/article/b91b2983d67042199d70adb7860fbe66
Autor:
Kam Tong Leung, Alex Wing Kwan Leung, Chi-kong Li, Patrick Man Pan Yuen, Chun Chen, Junbin Huang, Qi Zhao, Ellen Ngar Yun Poon, Raymond S.M. Wong, Wayne Yuk Wai Lee, Ka-Fai To, Wei Kang, Patrick Ming-Kuen Tang, Wing Hei Ng, John Tak Kit Cheung, Yaqun Xu, Chi Zhang, Qiwei Sun, Yuet Ping Yuen, Chi Chiu So, Xiao-Bing Zhang, Tao Zhang, Chi Chiu Wang, Anskar Y.H. Leung, Wing Hang Leung, Alan K.S. Chiang, Shau Yin Ha, Tin Wai Chow, Grace Kee See Lam, Frankie Wai Tsoi Cheng, Po Yi Lee, Margaret H.L. Ng, Chi Keung Cheng, Kathy Yuen Yee Chan, Han Wang
Supplementary Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340814653f430c54d027ddfe44a87c37
https://doi.org/10.1158/2643-3230.22545317.v1
https://doi.org/10.1158/2643-3230.22545317.v1
Autor:
Kam Tong Leung, Alex Wing Kwan Leung, Chi-kong Li, Patrick Man Pan Yuen, Chun Chen, Junbin Huang, Qi Zhao, Ellen Ngar Yun Poon, Raymond S.M. Wong, Wayne Yuk Wai Lee, Ka-Fai To, Wei Kang, Patrick Ming-Kuen Tang, Wing Hei Ng, John Tak Kit Cheung, Yaqun Xu, Chi Zhang, Qiwei Sun, Yuet Ping Yuen, Chi Chiu So, Xiao-Bing Zhang, Tao Zhang, Chi Chiu Wang, Anskar Y.H. Leung, Wing Hang Leung, Alan K.S. Chiang, Shau Yin Ha, Tin Wai Chow, Grace Kee See Lam, Frankie Wai Tsoi Cheng, Po Yi Lee, Margaret H.L. Ng, Chi Keung Cheng, Kathy Yuen Yee Chan, Han Wang
Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia (AML), direct implementation in children is challenging due to inherent differences in underlying genetics. Here we established the pharmacologic profile of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41072df45b1d12a7e0dd4c70d3befc4e
https://doi.org/10.1158/2643-3230.c.6550904
https://doi.org/10.1158/2643-3230.c.6550904
Autor:
Kam Tong Leung, Alex Wing Kwan Leung, Chi-kong Li, Patrick Man Pan Yuen, Chun Chen, Junbin Huang, Qi Zhao, Ellen Ngar Yun Poon, Raymond S.M. Wong, Wayne Yuk Wai Lee, Ka-Fai To, Wei Kang, Patrick Ming-Kuen Tang, Wing Hei Ng, John Tak Kit Cheung, Yaqun Xu, Chi Zhang, Qiwei Sun, Yuet Ping Yuen, Chi Chiu So, Xiao-Bing Zhang, Tao Zhang, Chi Chiu Wang, Anskar Y.H. Leung, Wing Hang Leung, Alan K.S. Chiang, Shau Yin Ha, Tin Wai Chow, Grace Kee See Lam, Frankie Wai Tsoi Cheng, Po Yi Lee, Margaret H.L. Ng, Chi Keung Cheng, Kathy Yuen Yee Chan, Han Wang
Supplementary Figure from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242d586dd08c36ec116ff3489f689f1d
https://doi.org/10.1158/2643-3230.22545314
https://doi.org/10.1158/2643-3230.22545314
Autor:
Kam Sze Tsang, Alex Wing Kwan Leung, Vincent Lee, Frankie Wai Tsoi Cheng, Matthew Ming Kong Shing, Henry Nga Hin Pong, Ting Fan Leung, Patrick Man Pan Yuen, Chi Kong Li
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Double-unit umbilical cord blood (DU-UCB) may extend the use of UCB transplantation and improve clinical outcomes. Data in the literature show that single-unit dominance happened in a vast majority of recipients, and the mechanism is unknown. We exam
Externí odkaz:
https://doaj.org/article/3a85ba8e8e804976829806ac30bfce3e
Autor:
Han Wang, Kathy Yuen Yee Chan, Chi Keung Cheng, Margaret H.L. Ng, Po Yi Lee, Frankie Wai Tsoi Cheng, Grace Kee See Lam, Tin Wai Chow, Shau Yin Ha, Alan K.S. Chiang, Wing Hang Leung, Anskar Y.H. Leung, Chi Chiu Wang, Tao Zhang, Xiao-Bing Zhang, Chi Chiu So, Yuet Ping Yuen, Qiwei Sun, Chi Zhang, Yaqun Xu, John Tak Kit Cheung, Wing Hei Ng, Patrick Ming-Kuen Tang, Wei Kang, Ka-Fai To, Wayne Yuk Wai Lee, Raymond S.M. Wong, Ellen Ngar Yun Poon, Qi Zhao, Junbin Huang, Chun Chen, Patrick Man Pan Yuen, Chi-kong Li, Alex Wing Kwan Leung, Kam Tong Leung
Publikováno v:
Blood cancer discovery. 3(6)
Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia (AML), direct implementation in children is challenging due to inherent differences in underlying genetics. Here we established the pharmacologic profile of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca555489fe5f18c2d08b830dac9f9f2
https://pubmed.ncbi.nlm.nih.gov/35960210
https://pubmed.ncbi.nlm.nih.gov/35960210
Autor:
Karen Li, Ka Fai To, Ellen Ngar Yun Poon, Margaret H.L. Ng, Tak Yeung Leung, Han Wang, Chi Zhang, King Yiu Lee, Kam Tong Leung, Chun Chen, Cheuk-Kwong Lee, Patrick Ming-Kuen Tang, Wing Hei Ng, Alex Wing Kwan Leung, Patrick Man Pan Yuen, Kathy Yuen Yee Chan, Chi Chiu Wang, Chi Kong Li, Pak Cheung Ng, Yorky Tsin Sik Wong, Xiao-Bing Zhang, Siu Ping Fok, Wei Kang, Bo Feng, Hugh Simon Lam
Publikováno v:
Blood Advances
Key Points Specific R4 RGS members are expressed in human HSPCs and regulated by the SDF-1/CXCR4 axis.RGS1/13/16 suppress HSPC engraftment, SDF-1 signaling, and key effectors of stem cell trafficking/maintenance.
Visual Abstract
Homing and
Visual Abstract
Homing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fff6844ffe044612e1d8de4ceb6050
https://pubmed.ncbi.nlm.nih.gov/34500454
https://pubmed.ncbi.nlm.nih.gov/34500454
Publikováno v:
Cell Transplantation, Vol 9 (2000)
As an early acting growth factor, flt-3 ligand (FL) promotes the ex vivo expansion of hematopoietic stem and progenitor cells. The effect and mechanism of FL on the development of the megakaryocytic lineage remain unclear. In this study, we compared
Externí odkaz:
https://doaj.org/article/a6d80ed6b77c47fcb10a314c09e95a57
Autor:
Kam Tong Leung, Grace Kee See Lam, Kam Sze Tsang, Ka Fai To, Karen Li, John Tak Kit Cheung, Margaret H.L. Ng, Toni Ki Fong Man, Han Wang, Jasmine Wai Sum Yu, Wei Kang, Xiao-Bing Zhang, Tin Wai Chow, Alex Wing Kwan Leung, Kathy Yuen Yee Chan, Ting Fan Leung, Tony Sit, Frankie W.T. Cheng, Wayne Yuk-Wai Lee, Chi Kong Li, Chi Zhang, Patrick Man Pan Yuen, Pak Cheung Ng
Publikováno v:
Leukemia. 34(3)
CD9 has been implicated in cancer progression but its prognostic relevance and therapeutic potential in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are largely unknown. In a cohort of pediatric BCP-ALL patients, we found that CD9+ cases h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab7de28b88f66c45b4b6d58d701d6ed
https://pubmed.ncbi.nlm.nih.gov/31624373
https://pubmed.ncbi.nlm.nih.gov/31624373
Autor:
Chi Kong Li, Paul K.S. Chan, Wing Kwan Leung, Ting Fan Leung, Patrick Man Pan Yuen, Ming Kong Shing, Vincent Lee, Frankie W.T. Cheng
Publikováno v:
Pediatric Hematology and Oncology. 27:195-204
The recovery of antibodies to various vaccine-preventable infectious diseases, humoral and cellular immunity in pediatric oncology patients were evaluated by a prospective longitudinal study for 18 months. Lymphocyte subset (CD3+, CD4+, CD8+, CD16/56
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04803becbdda73eb28c588e9118547b
https://doi.org/10.3109/08880011003621752
https://doi.org/10.3109/08880011003621752