Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA)

Autor: In Pyo Hwang, Patrick Mailliet, Virginie Hossard, Jean-Francois Riou, Anthony Bugaut, Lauréline Roger

Publikováno v: Molecules, Vol 24, Iss 3, p 577 (2019)

Telomeres are nucleoprotein structures that cap and protect the natural ends of chromosomes. Telomeric DNA G-rich strands can form G-quadruplex (or G4) structures. Ligands that bind to and stabilize G4 structures can lead to telomere dysfunctions by

Externí odkaz: https://doaj.org/article/639e2c04a5934744a170d85881e1796f

ChemInform Abstract: Ring-Closing Enyne Metathesis of Terminal Alkynes with Propargylic Hindrance

Autor: Bastien Nay, Lionel Dubost, Patrick Mailliet, Benjamin Laroche, Morgane Detraz, Alain Blond

Publikováno v: ChemInform. 46

The ring closing enyne metathesis of substrates with propargylic hindrance was investigated, revealing the successful combination of the Stewart-Grubbs catalysts and microwave heating sometimes up to 170 °C for oxacycles. Medium-sized rings were obt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2567775ba5adcf234f53c39691dd329
https://doi.org/10.1002/chin.201540055

Total Synthesis of Herbimycin A

Autor: Sophie Canova, Serge Mignani, Antony Bigot, Janine Cossy, Véronique Bellosta, Patrick Mailliet

Publikováno v: Organic Letters. 9:145-148

[structure: see text] Hsp90 has recently emerged as a promising biological target for treatment of cancer. Herbimycin A and other members of the benzoquinoid ansamycin class of natural products are known to inhibit Hsp90 activity. The total synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f833c913bf5607b14acbb61ed0e7f
https://doi.org/10.1021/ol062642i

Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

Autor: Céline Douarre, Jean-François Riou, Hamid Morjani, Marie-Françoise O'Donohue, Chantal Trentesaux, Patrick Mailliet, Lahcen Eddabra, Dennis Gomez, Jean-Marie Zahm

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2005, 33 (7), pp.2192-2203. ⟨10.1093/nar/gki514⟩
Nucleic Acids Research, Oxford University Press, 2005, 33 (7), pp.2192-203. ⟨10.1093/nar/gki514⟩
Nucleic Acids Research, 2005, 33 (7), pp.2192-203. ⟨10.1093/nar/gki514⟩

International audience; The triazine derivative 12459 is a potent G-quadruplex interacting agent that inhibits telomerase activity. This agent induces time- and dose-dependent telomere shortening, senescence-like growth arrest and apoptosis in the hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd338d868e811dff30e13d8a488e0e1
http://europepmc.org/articles/PMC1079972

Diastereoselective Syntheses of New Analogues of the Farnesyltransferase Inhibitor RPR 130401

Autor: Nicolas Pichon, Anne Marrison‐Marchand, Jacques Maddaluno, Patrick Mailliet

Publikováno v: The Journal of Organic Chemistry. 69:7220-7227

The access to several benzo[f]perhydroisoindolic analogues of farnesyltransferase inhibitors from a single dienic precursor is reported. An initial [4 + 2] cycloaddition between diphenylisobenzofuran6 and pyrrolines 11, 14, and 15 led to either the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29038adcf7e4c95fe162c12673bfbbf7
https://doi.org/10.1021/jo049037i