Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Patrick M. Sullivan"'
Autor:
Christophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo-Garcia, Patrick M. Sullivan, Emmanuel L. Gautier, Nadine Reichhart, José-Alain Sahel, Marie E. Burns, Michel Paques, Torben Lykke Sørensen, Olaf Strauss, Xavier Guillonneau, Cécile Delarasse, Florian Sennlaub
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial cells but also of monocyte-deriv
Externí odkaz:
https://doaj.org/article/15a2fe8398d24307833b4ae362a8cd9b
Autor:
Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Patrick M. Sullivan, Hussein N. Yassine
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-21 (2022)
Abstract Background Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease (AD), but the mechanisms for this association are not clear. The activation of calciu
Externí odkaz:
https://doaj.org/article/9b6fcfbf82ae45668070da91de7eda75
Autor:
Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti, Francis Shue, Tammee M. Parsons, Ralph B. Perkerson, Keiji Kawatani, Ni Wang, Skylar C. Starling, Bhaskar Roy, Ioana-Emilia Mosneag, Tomonori Aikawa, Marie-Louise Holm, Chia-Chen Liu, Yasuteru Inoue, Patrick M. Sullivan, Yan W. Asmann, Betty Y.S. Kim, Guojun Bu, Takahisa Kanekiyo
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second most prevalent cause of dementia in the elderly, after Alzheimer’s
Externí odkaz:
https://doaj.org/article/3982980e6d7948619fd5c5933bf5242e
Autor:
Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Carol Miller, Patrick M. Sullivan, Hoau-Yan Wang, Hussein N. Yassine
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)
Abstract Background Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease (AD), but the mechanisms for this association are not clear. The activation of calciu
Externí odkaz:
https://doaj.org/article/754e453573674c8fbaddf6c526d4ec90
Autor:
Jenny R. Diaz, Mitchell Martá-Ariza, Alireza Khodadadi-Jamayran, Adriana Heguy, Aristotelis Tsirigos, Joanna E. Pankiewicz, Patrick M. Sullivan, Martin J. Sadowski
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The APOE gene is diversified by three alleles ε2, ε3, and ε4 encoding corresponding apolipoprotein (apo) E isoforms. Possession of the ε4 allele is signified by increased risks of age-related cognitive decline, Alzheimer’s disease (AD), and the
Externí odkaz:
https://doaj.org/article/310c629614a240ba91a7f8f03701f288
Autor:
Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, Wenjie Luo
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Genome-wide association studies of Alzheimer’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators of neuroinflammation
Externí odkaz:
https://doaj.org/article/8c787cef8c4b4f1ea698d77807c4d44c
Autor:
Juliet Emamaullee, Sara Khan, Carly Weaver, Cameron Goldbeck, George Yanni, Rohit Kohli, Yuri Genyk, Shengmei Zhou, Nick Shillingford, Patrick M. Sullivan, Cheryl Takao, Jon Detterich, Paul F. Kantor, John D. Cleveland, Cynthia Herrington, S. Ram Kumar, Vaughn Starnes, Sarah Badran, Neil D. Patel
Publikováno v:
JHEP Reports, Vol 3, Iss 6, Pp 100362- (2021)
Background & Aims: Fontan-associated liver disease (FALD) has emerged as an important morbidity following surgical palliation of single ventricle congenital heart disease. In this study, non-invasive biomarkers that may be associated with severity of
Externí odkaz:
https://doaj.org/article/0ffbc80adb954ee9ba63a6625523ab24
Autor:
Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Carol Miller, Patrick M. Sullivan, Hoau-Yan Wang, Hussein N. Yassine
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-1 (2022)
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13024-021-00438-3.
Externí odkaz:
https://doaj.org/article/308e3d75b842470bb5c9e329f202d108
Autor:
Amy E. Baek, Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, Hannah B. McDowell, J. Will Thompson, Laura G. Dubois, Patrick M. Sullivan, Jongsook K. Kemper, Michael D. Gunn, Donald P. McDonnell, Erik R. Nelson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
High cholesterol is a risk factor for breast cancer recurrence. Here the authors show that cholesterol promotes breast cancer metastasis via its metabolite 27-hydroxycholesterol (27HC) that acts on immune myeloid cells residing at the distal metastat
Externí odkaz:
https://doaj.org/article/f990d083ec9e44f8ab4139f27a94e9ba
Autor:
Lance A. Johnson, Reid H.J. Olsen, Louise S. Merkens, Andrea DeBarber, Robert D. Steiner, Patrick M. Sullivan, Nobuyo Maeda, Jacob Raber
Publikováno v:
Neurobiology of Disease, Vol 64, Iss , Pp 150-162 (2014)
Human apolipoprotein E (apoE) exists in three isoforms: apoE2, apoE3 and apoE4. APOE ε4 is a major genetic risk factor for cardiovascular disease (CVD) and Alzheimer's disease (AD). ApoE mediates cholesterol metabolism by binding various receptors.
Externí odkaz:
https://doaj.org/article/e423708891324e4fb137181d0ad41de6