Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Patrick M. Slocombe"'
Autor:
Alice M. Barkell, Lorna C. Waters, Mark D. Carr, Martyn K. Robinson, Vaclav Veverka, Frederick W. Muskett, Alistair James Henry, Patrick M. Slocombe, Gill Holdsworth
Publikováno v:
Biomolecular NMR Assignments. 9:147-151
A number of proteins have been shown to modulate canonical Wnt signalling at the cell surface, including members of the Dickkopf (Dkk) family (Baron and Rawadi in J Endocrinol 148:2635-2643, 2007; Cruciat and Niehrs in Cold Spring Harb Perspect Biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e30c071c8f4bb26bee45b47e8dfbda7
https://doi.org/10.1007/s12104-014-9562-2
https://doi.org/10.1007/s12104-014-9562-2
Autor:
Mark D. Carr, Andrew Ventom, Jianhua Gong, Kevin Greenslade, Vaclav Veverka, Chris Paszty, Li Zhang, Martyn K. Robinson, Richard J. K. Taylor, Mariusz Muzylak, Alistair James Henry, Patrick M. Slocombe, Xueming Qian, Adrian Moore, Barbara Mulloy, Frederick W. Muskett
Publikováno v:
Journal of Biological Chemistry. 284:10890-10900
The secreted glycoprotein sclerostin has recently emerged as a key negative regulator of Wnt signaling in bone and has stimulated considerable interest as a potential target for therapeutics designed to treat conditions associated with low bone mass,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d89f5c62070519d1b7ac2312cf28f01
https://doi.org/10.1074/jbc.m807994200
https://doi.org/10.1074/jbc.m807994200
Autor:
Rodger A. Allen, Yung Hou Wong, Yaji Tian, Lisa Y. Yung, Breda Twomey, Maggie M. K. Lee, Patrick M. Slocombe
Publikováno v:
Cellular Signalling. 20:1179-1189
Chemokines are known to regulate the chemotaxis of leukocytes and play an important role in immunological processes. Chemokine receptors are widely distributed in hematopoietic cells and are often co-localized with the hematopoietic-specific G(16) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc83698a7f82d8d176ae96aad6d00ee2
https://doi.org/10.1016/j.cellsig.2008.02.014
https://doi.org/10.1016/j.cellsig.2008.02.014
Autor:
Patrick M. Slocombe, David C. New, Maggie M. K. Lee, Yung Hou Wong, Yaji Tian, Lisa Y. Yung, Breda Twomey, Rodger A. Allen
Publikováno v:
European Journal of Immunology. 34:785-795
Chemokines regulate the chemotaxis, development, and differentiation of many cell types enabling the regulation of routine immunosurveillance and immunological adaptation. CC chemokine receptor 1 (CCR1) is the target of 11 chemokines. This promiscuit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b274bc4aa0399a7e1980e05e8389cf87
https://doi.org/10.1002/eji.200324166
https://doi.org/10.1002/eji.200324166
Autor:
Mark D. Carr, Mariusz Muzylak, David McMillan, Richard J. Franklin, Vaclav Veverka, Daniel Christopher Brookings, Joanne E. Compson, Kelly Le Riche, Laura Ellen Newnham, Carl Brendan Doyle, Thomas A Ceska, Rachael Garlish, James Petrie Turner, Jiye Shi, Bernadette Sweeney, Alistair James Henry, Patrick M. Slocombe, Jeffery Kennedy, Gill Holdsworth, Martyn K. Robinson
Publikováno v:
The Journal of biological chemistry. 287(32)
LRP5 and LRP6 are proteins predicted to contain four six-bladed β-propeller domains and both bind the bone-specific Wnt signaling antagonist sclerostin. Here, we report the crystal structure of the amino-terminal region of LRP6 and using NMR show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264cb99223c5808bb96a9f6cf30f0c4e
https://pubmed.ncbi.nlm.nih.gov/22696217
https://pubmed.ncbi.nlm.nih.gov/22696217
Autor:
Vaclav, Veverka, Alistair J, Henry, Patrick M, Slocombe, Andrew, Ventom, Barbara, Mulloy, Frederick W, Muskett, Mariusz, Muzylak, Kevin, Greenslade, Adrian, Moore, Li, Zhang, Jianhua, Gong, Xueming, Qian, Chris, Paszty, Richard J, Taylor, Martyn K, Robinson, Mark D, Carr
Publikováno v:
The Journal of biological chemistry. 284(16)
The secreted glycoprotein sclerostin has recently emerged as a key negative regulator of Wnt signaling in bone and has stimulated considerable interest as a potential target for therapeutics designed to treat conditions associated with low bone mass,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46c028547915cd7399181ba5f61e83f3
https://pubmed.ncbi.nlm.nih.gov/19208630
https://pubmed.ncbi.nlm.nih.gov/19208630
Publikováno v:
Gene. 350(1)
The CHO-K1 cell line is commonly used for studies of recombinantly expressed proteins, including proteins of the G protein-coupled receptor (GPCR) family. This laboratory has used CHO-K1 cells for the functional characterization of Edg family GPCRs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568e8b2338691d45ef6ffb16d27a24d3
https://pubmed.ncbi.nlm.nih.gov/15780969
https://pubmed.ncbi.nlm.nih.gov/15780969
Autor:
Paul E. Stephens, C. Graham Knight, Ailsa Webster, Andrew J. P. Docherty, Vera Knäuper, Gillian Murphy, Augustin Amour, Patrick M. Slocombe
Publikováno v:
FEBS letters. 473(3)
A recombinant soluble form of the catalytic domain of human ADAM-10 was expressed as an Fc fusion protein from myeloma cells. The ADAM-10 was catalytically active, cleaving myelin basic protein and peptides based on the previously described ‘metall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe0ff10bc3abdb5cfa6061f3fd583ea
https://pubmed.ncbi.nlm.nih.gov/10818225
https://pubmed.ncbi.nlm.nih.gov/10818225
Autor:
Andrew J. P. Docherty, Mike Hutton, Gillian Murphy, Michael J. Butler, Augustin Amour, Patrick M. Slocombe, Vera Knäuper, Ailsa Webster, Bryan J. Smith, C. Graham Knight
Publikováno v:
Annals of the New York Academy of Sciences. 878
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0090acf7b776ee8b1b1072652868725
https://pubmed.ncbi.nlm.nih.gov/10415820
https://pubmed.ncbi.nlm.nih.gov/10415820
Autor:
John V. Reynolds, Andrew J. P. Docherty, R V Ward, Gillian Murphy, Patrick M. Slocombe, Susan J. Atkinson
Publikováno v:
Biochimica et biophysica acta. 1079(2)
We report that monolayers of human fibroblasts stimulated with concanavalin A were able to activate 72 kDa progelatinase but not 95 kDa progelatinase. The activating capacity of fibroblasts appeared approx. 6 h after concanavalin A stimulation and wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1ca43a1fb51ab6249fc520e167eeec
https://pubmed.ncbi.nlm.nih.gov/1911847
https://pubmed.ncbi.nlm.nih.gov/1911847