Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Patrick M. Nolan"'
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102618- (2023)
Summary: The mammalian suprachiasmatic nucleus (SCN) is the principal circadian clock that synchronizes daily behavioral and physiological responses in response to environmental cues. Here, we present a protocol for harvesting mouse SCN by vibrating
Externí odkaz:
https://doaj.org/article/94c20f39e26246e1bbbe024f75e229f0
Autor:
Rasneer S. Bains, Hamish Forrest, Rowland R. Sillito, J. Douglas Armstrong, Michelle Stewart, Patrick M. Nolan, Sara E. Wells
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. Video-tracking, in particular, lends itself to automated machine-learning technologies that have
Externí odkaz:
https://doaj.org/article/28abc31ac6754ee3a87926b410363df9
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 13, Iss , Pp 100082- (2022)
Shift work (work outside of standard daylight hours) is common throughout the Western world. However, there are notable health consequences to shift work, including increased prevalence of mental health and sleep disorders in shift worker populations
Externí odkaz:
https://doaj.org/article/92626e705ca042e1a3a4dff024f48189
Autor:
Ashleigh G. Wilcox, R. Sonia Bains, Debbie Williams, Elizabeth Joynson, Lucie Vizor, Peter L. Oliver, Elizabeth S. Maywood, Michael H. Hastings, Gareth Banks, Patrick M. Nolan
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103142- (2021)
Summary: Circadian rhythms persist in almost all organisms and are crucial for maintaining appropriate timing in physiology and behaviour. Here, we describe a mouse mutant where the central mammalian pacemaker, the suprachiasmatic nucleus (SCN), has
Externí odkaz:
https://doaj.org/article/d7a8f8dd4a4847d0a0de4873543deaee
Autor:
Eva Lana-Elola, Heather Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller-Winkler, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, Justin Tosh, Suzanna Noy, Miriam Llorian, Patrick M. Nolan, Julian L. Griffin, Mark Good, Michelle Simon, Ann-Marie Mallon, Sara Wells, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, these dosage-sensitive cau
Externí odkaz:
https://doaj.org/article/2e0de4e621364f88bbb0ae2f68e17fe9
Autor:
Lee Moir, Elena G. Bochukova, Rebecca Dumbell, Gareth Banks, Rasneer S. Bains, Patrick M. Nolan, Cheryl Scudamore, Michelle Simon, Kimberly A. Watson, Julia Keogh, Elana Henning, Audrey Hendricks, Stephen O'Rahilly, Inês Barroso, Adrienne E. Sullivan, David C. Bersten, Murray L. Whitelaw, Susan Kirsch, Elizabeth Bentley, I. Sadaf Farooqi, Roger D. Cox
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1419-1428 (2017)
Objective: Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis. Methods: In this study, we genetically mapped the chromosomal region underlying the development of severe obesity in
Externí odkaz:
https://doaj.org/article/9e406993ddb94b1f857c7323c01dc9e0
Autor:
Michelle Stewart, Petrina Lau, Gareth Banks, Rasneer Sonia Bains, Enrico Castroflorio, Peter L. Oliver, Christine L. Dixon, Michael C. Kruer, Dimitri M. Kullmann, Abraham Acevedo-Arozena, Sara E. Wells, Silvia Corrochano, Patrick M. Nolan
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 2 (2019)
Loss-of-function mutations in a human AMPA receptor-associated protein, ferric chelate reductase 1-like (FRRS1L), are associated with a devastating neurological condition incorporating choreoathetosis, cognitive deficits and epileptic encephalopathie
Externí odkaz:
https://doaj.org/article/d76387fa133742d3bce48ece5c214c9b
Autor:
Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute
Externí odkaz:
https://doaj.org/article/fa97ab87303c498f824c8286a0325379
Autor:
Edoardo Balzani, Glenda Lassi, Silvia Maggi, Siddharth Sethi, Michael J. Parsons, Michelle Simon, Patrick M. Nolan, Valter Tucci
Publikováno v:
Cell Reports, Vol 16, Iss 3, Pp 615-621 (2016)
An AT motif-dependent axis, modulated by the transcription factor Zfhx3, influences the circadian clock in mice. In particular, gain of function of Zfhx3 significantly shortens circadian rhythms and alters the transcriptional activity of an important
Externí odkaz:
https://doaj.org/article/1341c4559ff04eb6a552ef9fb4f895a2
Autor:
Silvia Mandillo, Ines Heise, Luciana Garbugino, Glauco P. Tocchini-Valentini, Alessandro Giuliani, Sara Wells, Patrick M. Nolan
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 3, Pp 397-407 (2014)
Deficits in motor function are debilitating features in disorders affecting neurological, neuromuscular and musculoskeletal systems. Although these disorders can vary greatly with respect to age of onset, symptomatic presentation, rate of progression
Externí odkaz:
https://doaj.org/article/c6cbf9ede2f641adb6d232fddbb4d9e2