Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrick M. Gubser"'
Autor:
Patrick M. Gubser, Sharanya Wijesinghe, Leonie Heyden, Sarah S. Gabriel, David P. de Souza, Christoph Hess, Malcolm M. McConville, Daniel T. Utzschneider, Axel Kallies
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114632- (2024)
Summary: Tumor cells undergo uncontrolled proliferation driven by enhanced anabolic metabolism including glycolysis and glutaminolysis. Targeting these pathways to inhibit cancer growth is a strategy for cancer treatment. Critically, however, tumor-r
Externí odkaz:
https://doaj.org/article/ed496fbd2a8c447f9858e95fb3791214
Autor:
Axel Kallies, Wei Shi, Daniel T. Utzschneider, Sarah S. Gabriel, Renee Gloury, Ajithkumar Vasanthakumar, David Chisanga, Patrick M Gubser
Publikováno v:
Nature Immunology. 21:1256-1266
CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e128aa6a3fd878ead5842c1d074fd9e3
https://doi.org/10.1038/s41590-020-0760-z
https://doi.org/10.1038/s41590-020-0760-z
Autor:
Sarah A. Best, Patrick M. Gubser, Shalini Sethumadhavan, Ariena Kersbergen, Yashira L. Negrón Abril, Joshua Goldford, Katherine Sellers, Waruni Abeysekera, Alexandra L. Garnham, Jackson A. McDonald, Clare E. Weeden, Dovile Anderson, David Pirman, Thomas P. Roddy, Darren J. Creek, Axel Kallies, Gillian Kingsbury, Kate D. Sutherland
Publikováno v:
Cell Metabolism. 34:874-887.e6
The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell growth and facilitate tumor development. Glucose and glutamine in the TME are essential for the development and activation of effector T cells that exert antitumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42447696929ae825a696176ba40aba29
https://doi.org/10.1016/j.cmet.2022.04.003
https://doi.org/10.1016/j.cmet.2022.04.003
Publikováno v:
Nature
SUMMARY Regulatory T (Treg) cells, vital for maintaining immune homeostasis, also represent a major barrier to cancer immunity, as the tumor microenvironment (TME) promotes Treg cell recruitment, differentiation, and activity1,2. Tumor cells have der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf40a54c858e8e7d4d8b901f04aee274
https://pubmed.ncbi.nlm.nih.gov/33589820
https://pubmed.ncbi.nlm.nih.gov/33589820
Autor:
Wei Shi, Daniel T. Utzschneider, Sarah S. Gabriel, Nicholas D. Huntington, Manuela Llano-León, Patrick M Gubser, David Chisanga, Laurent Bartholin, Flora Weber, Axel Kallies, Carlson Tsui, Fernando Souza-Fonseca-Guimaraes
Publikováno v:
Immunity. 54(8)
Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate, a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted (Tpex) cells that self-renew while continuously generating exhaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833ec0e046dbf331887de2ee347e1982
https://pubmed.ncbi.nlm.nih.gov/34233154
https://pubmed.ncbi.nlm.nih.gov/34233154
Autor:
Daniel T, Utzschneider, Sarah S, Gabriel, David, Chisanga, Renee, Gloury, Patrick M, Gubser, Ajithkumar, Vasanthakumar, Wei, Shi, Axel, Kallies
Publikováno v:
Nature immunology. 21(10)
CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00c0a01f14ca51589b0c195c98293c5c
https://pubmed.ncbi.nlm.nih.gov/32839610
https://pubmed.ncbi.nlm.nih.gov/32839610
Autor:
Marco, Fischer, Glenn R, Bantug, Sarah, Dimeloe, Patrick M, Gubser, Anne-Valérie, Burgener, Jasmin, Grählert, Maria L, Balmer, Leyla, Develioglu, Rebekah, Steiner, Gunhild, Unterstab, Ursula, Sauder, Gideon, Hoenger, Christoph, Hess
Publikováno v:
European journal of immunology. 48(10)
The role of mitochondrial biogenesis during naïve to effector differentiation of CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55a40e296343eee854962f694acb42d4
https://pubmed.ncbi.nlm.nih.gov/30028501
https://pubmed.ncbi.nlm.nih.gov/30028501