Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Patrick M. Carry"'
Autor:
Patrick M. Carry, Lauren A. Vanderlinden, Randi K. Johnson, Teresa Buckner, Andrea K. Steck, Katerina Kechris, Ivana V. Yang, Tasha E. Fingerlin, Oliver Fiehn, Marian Rewers, Jill M. Norris
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundType 1 diabetes (T1D) is preceded by a heterogenous pre-clinical phase, islet autoimmunity (IA). We aimed to identify pre vs. post-IA seroconversion (SV) changes in DNAm that differed across three IA progression phenotypes, those who lose a
Externí odkaz:
https://doaj.org/article/13d1cee8ffcf44c0a63da89f47ca487c
Autor:
Patrick M. Carry, Tim Vigers, Lauren A. Vanderlinden, Carson Keeter, Fran Dong, Teresa Buckner, Elizabeth Litkowski, Ivana Yang, Jill M. Norris, Katerina Kechris
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background We developed a novel approach to minimize batch effects when assigning samples to batches. Our algorithm selects a batch allocation, among all possible ways of assigning samples to batches, that minimizes differences in average pr
Externí odkaz:
https://doaj.org/article/f5f3161d1212472ba1fb4cc3ce02231b
Autor:
Teresa Buckner, Randi K. Johnson, Lauren A. Vanderlinden, Patrick M. Carry, Alex Romero, Suna Onengut-Gumuscu, Wei-Min Chen, Soojeong Kim, Oliver Fiehn, Brigitte I. Frohnert, Tessa Crume, Wei Perng, Katerina Kechris, Marian Rewers, Jill M. Norris
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
BackgroundOxylipins are inflammatory biomarkers derived from omega-3 and-6 fatty acids implicated in inflammatory diseases but have not been studied in a genome-wide association study (GWAS). The aim of this study was to identify genetic loci associa
Externí odkaz:
https://doaj.org/article/1fe4b1d6ea3a4185b725567210cde705
Autor:
Sulafa Elhassan, Fran Dong, Teresa Buckner, Randi K. Johnson, Jennifer A. Seifert, Patrick M. Carry, Lauren Vanderlinden, Kathleen Waugh, Marian Rewers, Jill M. Norris
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundStudies of the role of iron in the risk of type 1 diabetes (T1D) have been inconsistent. Given that iron generates reactive oxygen radicals, which can lead to oxidative damage and apoptosis in the beta cells of the pancreas, we examined whe
Externí odkaz:
https://doaj.org/article/30d76eca792b41168fc0dd1cbe9b638b
Autor:
Lauren A. Vanderlinden, Randi K. Johnson, Patrick M. Carry, Fran Dong, Dawn L. DeMeo, Ivana V. Yang, Jill M. Norris, Katerina Kechris
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Objective Illumina BeadChip arrays are commonly used to generate DNA methylation data for large epidemiological studies. Updates in technology over time create challenges for data harmonization within and between studies, many of which obtai
Externí odkaz:
https://doaj.org/article/70d7935c93f24ff6b5f49921e5cd5dfa
Autor:
Angelo Augusto M. Sumalde, Melissa A. Scholes, Olivia A. Kalmanson, Elizabeth A. Terhune, Lidia Frejo, Cambria I. Wethey, Pablo Roman-Naranjo, Patrick M. Carry, Samuel P. Gubbels, Jose A. Lopez-Escamez, Nancy Hadley-Miller, Regie Lyn P. Santos-Cortez
Publikováno v:
Genes, Vol 14, Iss 4, p 831 (2023)
Vertigo due to vestibular dysfunction is rare in children. The elucidation of its etiology will improve clinical management and the quality of life of patients. Genes for vestibular dysfunction were previously identified in patients with both hearing
Externí odkaz:
https://doaj.org/article/ecde0cae61534709b4a6d72867c6f590
Autor:
Teresa Buckner, Randi K. Johnson, Lauren A. Vanderlinden, Patrick M. Carry, Alex Romero, Suna Onengut-Gumuscu, Wei-Min Chen, Oliver Fiehn, Brigitte I. Frohnert, Tessa Crume, Wei Perng, Katerina Kechris, Marian Rewers, Jill M. Norris
Publikováno v:
Nutrients, Vol 15, Iss 4, p 945 (2023)
Oxylipins, pro-inflammatory and pro-resolving lipid mediators, are associated with the risk of type 1 diabetes (T1D) and may be influenced by diet. This study aimed to develop a nutrient pattern related to oxylipin profiles and test their association
Externí odkaz:
https://doaj.org/article/d28d6720d1c74c38bee409961a94e54f
Autor:
Tim Vigers, Lauren A. Vanderlinden, Randi K. Johnson, Patrick M. Carry, Ivana Yang, Brian C. DeFelice, Alexander M. Kaizer, Laura Pyle, Marian Rewers, Oliver Fiehn, Jill M. Norris, Katerina Kechris
Publikováno v:
Metabolites, Vol 11, Iss 8, p 542 (2021)
Environmental factors including viruses, diet, and the metabolome have been linked with the appearance of islet autoimmunity (IA) that precedes development of type 1 diabetes (T1D). We measured global DNA methylation (DNAm) and untargeted metabolomic
Externí odkaz:
https://doaj.org/article/714dbdf695d241429a1a4ba14acd0040
Autor:
Patrick M. Carry, Elizabeth A. Terhune, George D. Trahan, Lauren A. Vanderlinden, Cambria I. Wethey, Parvaneh Ebrahimi, Fiona McGuigan, Kristina Åkesson, Nancy Hadley-Miller
Publikováno v:
Genes, Vol 12, Iss 8, p 1191 (2021)
Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8 monozygotic twin pairs with IS, 6 discordant (Cobb angle difference > 10°) and 2 concordant (Cobb angle difference ≤ 2°). Genome-wide methylation in blood was meas
Externí odkaz:
https://doaj.org/article/ddfc7a3d1aa448d982bd5e1002898456
Autor:
Minami K. Yamamura, Patrick M. Carry, Romie F. Gibly, Kaley Holmes, Brandon Ogilvie, Alicia Phillips, Gaia Georgopoulos, Nancy Hadley Miller, Karin A. Payne
Publikováno v:
Journal of the American Academy of Orthopaedic Surgeons. 31:e507-e515