Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer

Autor: Ern-Yu, Tan, Lavina, Bharwani, Yee-Hong, Chia, Richie C T, Soong, Sherylyn S Y, Lee, Juliana J C, Chen, Patrick M Y, Chan

Publikováno v: World Journal of Clinical Oncology. 13:712-724

There are concerns that tamoxifen is less effective in Asian women because of the high prevalence of impaired function cytochrome P450 2D6 (To evaluate how knowledge ofEighty-two women were recruited. Seventy-eight completedMore than 70% of the women

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60332988a99e8b245e2ccc8eebbf2fcb
https://doi.org/10.5306/wjco.v13.i8.712

Circulating microRNA breast cancer biomarker detection in patient sera with surface plasmon resonance imaging biosensor

Autor: Patrick M. Y. Chan, Ann Siew Gek Lee, Ern Yu Tan, Malini Olivo, Hann Qian Lim, Ghayathri Balasundaram, Sau Yeen Loke, Bee Kiang Chong, Chi Lok Wong

Publikováno v: Journal of Biophotonics. 14

In this article, we report for the first time, the detection of circulating miRNA as a breast cancer biomarker in patient sera using surface plasmon resonance imaging biosensor. The advantage of this approach lies in the rapid, label-free and sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a19c9a7cb6381cd3df8b3e9e3276ef2
https://doi.org/10.1002/jbio.202100153

The therapeutic dilemma of idiopathic granulomatous mastitis

Autor: Ern Yu Tan, Ee Ling Serene Tang, Patrick M. Y. Chan, Juliana Jia Chuan Chen, Chi Shern Bernard Ho, Mui Heng Goh

Introduction: Idiopathic granulomatous mastitis (IGM) is a rare, benign, chronic breast condition that can cause repeated abscesses or mass formation in bilateral breasts. The condition can severely impact the quality of life of affected women. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6d8019ee856396c89295294239762e
https://hdl.handle.net/10356/161859

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Autor: Ava Kwong, Anna H. Wu, Kiat Tee Benita Tan, Joanne Ngeow, Anushya Vijayananthan, Kiak Mien Veronique Tan, Qin Wang, Taiki Yamaji, Tsun Leung Chan, Su Ming Tan, Hidemi Ito, Rob M. van Dam, Jaime Seah, Peh Joo Ho, Daniel O. Stram, Jacques Simard, Patrick M. Y. Chan, Chen-Yang Shen, Jingmei Li, Joe Dennis, Sook-Yee Yoon, Ern Yu Tan, Xueling Sim, Min Min Tan, Xiao-Ou Shu, Mei Chee Tai, Antonis C. Antoniou, Keitaro Matsuo, Suniza Jamaris, Chiea Chuen Khor, Jyh Cherng Yu, Sung-Won Kim, Kyriaki Michailidou, Paul D.P. Pharoah, Woon Puay Koh, Ji Yeob Choi, Shivaani Mariapun, Nasim Mavaddat, Geok Hoon Lim, Kartini Rahmat, John J. Spinelli, Swee Ho Lim, Cheng Har Yip, Kristan J. Aronson, Manjeet K. Bolla, Artitaya Lophatananon, Jonathan Tyrer, Motoki Iwasaki, Wei Zheng, Mikael Hartman, Siti Norhidayu Hasan, Nur Aishah Taib, Ching Wan Chan, Daehee Kang, Alison M. Dunning, Kenneth Muir, Weang Kee Ho, Douglas F. Easton, Soo H. Teo, Esther M. John, Sue K. Park, Wei Sean Yong, Allison W. Kurian

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Ho, W-K, Tan, M-M, Mavaddat, N, Tai, M-C, Mariapun, S, Li, J, Ho, P-J, Dennis, J, Tyrer, J P, Bolla, M K, Michailidou, K, Wang, Q, Kang, D, Choi, J-Y, Jamaris, S, Shu, X-O, Yoon, S-Y, Park, S K, Kim, S-W, Shen, C-Y, Yu, J-C, Tan, E Y, Chan, P M Y, Muir, K, Lophatananon, A, Wu, A H, Stram, D O, Matsuo, K, Ito, H, Chan, C W, Ngeow, J, Yong, W S, Lim, S H, Lim, G H, Kwong, A, Chan, T L, Tan, S M, Seah, J, John, E M, Kurian, A W, Koh, W-P, Khor, C C, Iwasaki, M, Yamaji, T, Tan, K M V, Tan, K T B, Spinelli, J J, Aronson, K J, Hasan, S N, Rahmat, K, Vijayananthan, A, Sim, X, Pharoah, P D P, Zheng, W, Dunning, A M, Simard, J, van Dam, R M, Yip, C-H, Taib, N A M, Hartman, M, Easton, D F, Teo, S-H & Antoniou, A C 2020, ' European polygenic risk score for prediction of breast cancer shows similar performance in Asian women ', Nature Communications, vol. 11, no. 1, pp. 3833 . https://doi.org/10.1038/s41467-020-17680-w

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6728703dff51f0af0e215a568d8a53a9
http://europepmc.org/articles/PMC7395776

Majority of flat epithelial atypia diagnosed on biopsy do not require surgical excision

Autor: Bee Kiang Chong, Bernard Ho, Pei Yi Sin, Patrick M. Y. Chan, Ern Yu Tan, Sarah Qinghui Lu, Mui Heng Goh, Eileen Shujuan Lai, Juliana Chen, Niketa Chotai

Publikováno v: Breast (Edinburgh, Scotland). 37

Background Borderline risk lesions such as flat epithelial atypia (FEA) are increasingly being diagnosed on biopsy. The need for surgery is being debated. In this study, we determined the frequency of histological upgrade following a diagnosis of FEA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361321cfb5dc146a0ac9a0c94c3992fb
https://pubmed.ncbi.nlm.nih.gov/29040892