Zobrazeno 1 - 10
of 1 757
pro vyhledávání: '"Patrick M Sexton"'
Autor:
Kaleeckal G Harikumar, Peishen Zhao, Brian P Cary, Xiaomeng Xu, Aditya J Desai, Maoqing Dong, Jesse I Mobbs, Chirine Toufaily, Sebastian G B Furness, Arthur Christopoulos, Matthew J Belousoff, Denise Wootten, Patrick M Sexton, Laurence J Miller
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002673 (2024)
Development of optimal therapeutics for disease states that can be associated with increased membrane cholesterol requires better molecular understanding of lipid modulation of the drug target. Type 1 cholecystokinin receptor (CCK1R) agonist actions
Externí odkaz:
https://doaj.org/article/897ba52f46f9422aa4eba66be6e9d3a4
Autor:
Jean-Francois Gautier, Nicolas Venteclef, Assam El-Osta, Andrew J Murphy, Darren M Riddy, Helene L Kammoun, Sanja Bosnyak-Gladovic, Rocio De la Fuente Gonzalez, Jon Merlin, Mark Ziemann, Stewart Fabb, Tracie L Pierce, Natalie Diepenhorst, Patricia Rueda, William N Charman, Arthur Christopoulos, Patrick M Sexton, Roger J Summers, Mark A Febbraio, Philippe Delerive, Christopher J Langmead
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/4720f931b7654da0bb23e3c27d888fd0
Autor:
Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton
Publikováno v:
PLoS Biology, Vol 19, Iss 6, p e3001295 (2021)
G protein-coupled receptors (GPCRs) are critical regulators of cellular function acting via heterotrimeric G proteins as their primary transducers with individual GPCRs capable of pleiotropic coupling to multiple G proteins. Structural features gover
Externí odkaz:
https://doaj.org/article/74d05cb5885440089e6bbe22f303c143
Autor:
Darren M Riddy, Emily Goy, Philippe Delerive, Roger J Summers, Patrick M Sexton, Christopher J Langmead
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197177 (2018)
Monocyte-like cell lines (MCLCs), including THP-1, HL-60 and U-937 cells, are used routinely as surrogates for isolated human peripheral blood mononuclear cells (PBMCs). To systematically evaluate these immortalised cells and PBMCs as model systems t
Externí odkaz:
https://doaj.org/article/06eea1bb862d4727bf7f9a4135f38567
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 11, p e1005819 (2017)
G protein-coupled receptors (GPCRs) play crucial roles in cell physiology and pathophysiology. There is increasing interest in using structural information for virtual screening (VS) of libraries and for structure-based drug design to identify novel
Externí odkaz:
https://doaj.org/article/4e7ed5d171f84e11b0c5527b7366249d
Autor:
Patricia Rueda, Elizabeth Harley, Yao Lu, Gregory D Stewart, Stewart Fabb, Natalie Diepenhorst, Béatrice Cremers, Marie-Hélène Rouillon, Isabelle Wehrle, Anne Geant, Gwladys Lamarche, Katie Leach, William N Charman, Arthur Christopoulos, Roger J Summers, Patrick M Sexton, Christopher J Langmead
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146846 (2016)
Phenotyping of Gprc6a KO mice has shown that this promiscuous class C G protein coupled receptor is variously involved in regulation of metabolism, inflammation and endocrine function. Such effects are described as mediated by extracellular calcium,
Externí odkaz:
https://doaj.org/article/b658292f3cbd438ca68f91442b0499b5
Autor:
Kim Vietz Andreassen, Sara Toftegaard Hjuler, Sebastian G Furness, Patrick M Sexton, Arthur Christopoulos, Olivier Nosjean, Morten Asser Karsdal, Kim Henriksen
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92042 (2014)
Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here we analyze the differences between sCT and hCT on the human calcitonin receptor (CT(a)R) with respect to activ
Externí odkaz:
https://doaj.org/article/91614874790a494dabe08967edbb8255
Autor:
Brian P Cary, Xin Zhang, Jianjun Cao, Rachel M Johnson, Sarah J Piper, Elliot J Gerrard, Denise Wootten, Patrick M Sexton
Publikováno v:
Endocrine Reviews. 44:492-517
G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large extracellular domains (ECDs) and respond to long polypeptide hormones.
Autor:
Brian P. Cary, Elliot J. Gerrard, Matthew J. Belousoff, Madeleine M. Fletcher, Yan Jiang, Isabella C. Russell, Sarah J. Piper, Denise Wootten, Patrick M. Sexton
Publikováno v:
Structure.
Publikováno v:
Chemical Reviews. 122:13989-14017
Membrane proteins are highly diverse in both structure and function and can, therefore, present different challenges for structure determination. They are biologically important for cells and organisms as gatekeepers for information and molecule tran