Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrick M Loerch"'
Autor:
Patrick M Loerch, Tao Lu, Kelly A Dakin, James M Vann, Adrian Isaacs, Chengiz Geula, Jianbin Wang, Ying Pan, Dana H Gabuzda, Cheng Li, Tomas A Prolla, Bruce A Yankner
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3329 (2008)
Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to humans. To obtain greater insight into how brain aging has evolved, we compared age-related gen
Externí odkaz:
https://doaj.org/article/03fa2e135d314d6ba4496e8c037ba2a0
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
Autor:
Judith Stegmüller, Ralph Scully, James M. Vann, Sarah M. Wright, David A. Sinclair, Andrea J. Hartlerode, Michael McVay, Frederick W. Alt, Azad Bonni, Tomas A. Prolla, Bruce A. Yankner, Shaday Michan, Kevin D. Mills, Raul Mostoslavsky, Sang-Kyu Park, Angela Hafner, Patrick M. Loerch, Philipp Oberdoerffer
Publikováno v:
Cell. 135:907-918
Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging. The yeast histone deacetylase Sir2 silences transcription and stabilizes repetitive DNA, but during aging or in response to a DNA break, the Sir complex relocal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741dff559dbd7ea297f1ab834c5caaa7
https://doi.org/10.1016/j.cell.2008.10.025
https://doi.org/10.1016/j.cell.2008.10.025
Autor:
Daniel D. Shoemaker, John C. Castle, Zhengyan Kan, Jason M. Johnson, Roland Stoughton, Patrick M. Loerch, Christopher D. Armour, Philip W. Garrett-engele, Eric E. Schadt, Ralph Santos
Publikováno v:
Science. 302:2141-2144
Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in development, physiology, and disease, and more than half of human genes are alternatively spliced. To understand the biological roles and regulation of alternative splicing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8436ef81b5a8d24dfb73067ae054d1
https://doi.org/10.1126/science.1090100
https://doi.org/10.1126/science.1090100
Autor:
Jyoti Shah, Jason M. Johnson, Christopher K. Raymond, Ronghua Chen, Christopher D. Armour, Patrick M. Loerch, Stuart Jackson, John Dey, Tomas Babak, John C. Castle, Carol A. Rohl
Publikováno v:
Nature methods. 6(9)
To deplete abundant rRNA from total RNA during cDNA library generation, hexamer primers that perfectly match rRNA are removed. These 'not so randomly primed' cDNA libraries can be generated from small amount of total RNA, preserve strand orientation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7995b6d12101057b66a86cd7abc5c16d
https://pubmed.ncbi.nlm.nih.gov/19668204
https://pubmed.ncbi.nlm.nih.gov/19668204
Autor:
William J. Ray, Patrick M. Loerch, Ramon Miguel Caceres, Xiaohua Douglas Zhang, Luiz M Camargo, Kenji Mizuguchi, John Majercak, Marc Ferrer, David J. Stone, Shane Marine, Chen Yi-An, Emanuele de Rinaldis, Paolo Uva, Mark S. Shearman
Publikováno v:
PLoS ONE
Camargo, L M, Zhang, X D, Loerch, P, Caceres, R M, Marine, S D, Uva, P, Ferrer, M, de Rinaldis, E, Stone, D J, Majercak, J, Ray, W J, Yi-An, C, Shearman, M S & Mizuguchi, K 2015, ' Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing ', PLoS ONE, vol. 10, no. 2, e0115369 . https://doi.org/10.1371/journal.pone.0115369
PLoS ONE, Vol 10, Iss 2, p e0115369 (2015)
Camargo, L M, Zhang, X D, Loerch, P, Caceres, R M, Marine, S D, Uva, P, Ferrer, M, de Rinaldis, E, Stone, D J, Majercak, J, Ray, W J, Yi-An, C, Shearman, M S & Mizuguchi, K 2015, ' Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing ', PLoS ONE, vol. 10, no. 2, e0115369 . https://doi.org/10.1371/journal.pone.0115369
PLoS ONE, Vol 10, Iss 2, p e0115369 (2015)
The progressive aggregation of Amyloid-β (Aβ) in the brain is a major trait of Alzheimer's Disease (AD). Aβ is produced as a result of proteolytic processing of the β-amyloid precursor protein (APP). Processing of APP is mediated by multiple enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7701ee6a87a8afdf554aa295174f8459
https://doi.org/10.1371/journal.pone.0115369
https://doi.org/10.1371/journal.pone.0115369
Autor:
B. Li, Jason R. King, Greg Schimmack, Paul McDonagh, Matthew J. Marton, Hongyue Dai, Yudong D. He, Stephen W. Scherer, Lani F. Wu, Peter S. Linsley, Pek Yee Lum, Patrick M. Loerch, J. S. Tsang, Philip W. Garrett-engele, P. Cundiff, J. Koch, Michael Ziman, Christopher D. Armour, M. S. Boguski, Thomas R. Ward, Janell M. Schelter, Seve Edwards, Steven J. Altschuler, Eric E. Schadt, Mao Mao, M. Krolewski, John C. Castle, Julja Burchard, Amy Leonardson, Roland Stoughton, John W. Phillips, Daniel D. Shoemaker, Guy Cavet, Miriam Meyer, Matthew J. Kidd
Publikováno v:
Nature. 409(6822)
The most important product of the sequencing of a genome is a complete, accurate catalogue of genes and their products, primarily messenger RNA transcripts and their cognate proteins. Such a catalogue cannot be constructed by computational annotation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59999f144ad1ac2f426b2e045bed073
https://pubmed.ncbi.nlm.nih.gov/11237012
https://pubmed.ncbi.nlm.nih.gov/11237012
Autor:
Patrick M. Loerch, Jason M. Johnson, Daniel D. Shoemaker, Phil Garrett-Engele, Michael R. Meyer, Mark L Parrish, Roland Stoughton, John C. Castle, Christopher D. Armour, Sven Duenwald, Eric E. Schadt
Publikováno v:
Genome Biology. 4:R66
Microarrays offer a high-resolution means for monitoring pre-mRNA splicing on a genomic scale. We have developed a novel, unbiased amplification protocol that permits labeling of entire transcripts. Also, hybridization conditions, probe characteristi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a35a84b17715a0fa70acf76194bee67
https://doi.org/10.1186/gb-2003-4-10-r66
https://doi.org/10.1186/gb-2003-4-10-r66