Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Patrick M Giguère"'
Autor:
Corina M Stewart, Alexandra Phan, Yuxia Bo, Nicholas D LeBlond, Tyler K T Smith, Geneviève Laroche, Patrick M Giguère, Morgan D Fullerton, Martin Pelchat, Darwyn Kobasa, Marceline Côté
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009275 (2021)
Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect cells, filoviruses are internalized via macropinocytosis and traffic through the endosomal pat
Externí odkaz:
https://doaj.org/article/c6998978276948f2b5a5a62d2e027cdc
Autor:
Dustin E Bosch, Adam J Kimple, Robin E Muller, Patrick M Giguère, Mischa Machius, Francis S Willard, Brenda R S Temple, David P Siderovski
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003040 (2012)
Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative agent of amoeb
Externí odkaz:
https://doaj.org/article/4362270682cc4067a9e0e1c85c876670
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Representing the most attractive and successful druggable receptors of the proteome, GPCRs regulate a myriad of physiological and pathophysiological functions. Although over half of present pharmaceuticals target GPCRs, the advancement of dr
Externí odkaz:
https://doaj.org/article/fec0d6604944450cb05f7a19f09c593c
Autor:
Abdulhamid O. Mohamud, Manel Zeghal, Shivani Patel, Geneviève Laroche, Nuria Blgacim, Patrick M. Giguère
Publikováno v:
ACS Omega. 7:16939-16951
Existing pharmacotherapies acting on the opioid receptor system have been extensively used to treat chronic pain and addictive disorders. Nevertheless, the adverse side effects associated with opioid therapy underscore the need for concerted measures
Autor:
Manel Zeghal, Kevin Matte, Angelica Venes, Shivani Patel, Geneviève Laroche, Sabina Sarvan, Monika Joshi, Jean-François Couture, Patrick M. Giguère
/SUMMARYProtein-protein interactions (PPIs) form the underpinnings of any cellular signaling network. PPIs are highly dynamic processes and often, cell-based assays can be essential for their study as they closely mimic the biological intricacies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a5fa096e221a77de7142a759220e5ce
https://doi.org/10.1101/2023.02.05.527200
https://doi.org/10.1101/2023.02.05.527200
Autor:
Mehdi Benlarbi, Geneviève Laroche, Corby Fink, Kathy Fu, Rory P. Mulloy, Alexandra Phan, Ardeshir Ariana, Corina M. Stewart, Jérémie Prévost, Guillaume Beaudoin-Bussières, Redaet Daniel, Yuxia Bo, Julien Yockell-Lelièvre, William L. Stanford, Patrick M. Giguère, Samira Mubareka, Andrés Finzi, Gregory A. Dekaban, Jimmy D. Dikeakos, Marceline Côté
To infect cells, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) via its spike glycoprotein (S), delivering its genome upon S-mediated membrane fusion. SARS-CoV-2 uses two distinct entry pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd8d48ab254fb8031be57f871f5581a
https://doi.org/10.1101/2022.02.19.481107
https://doi.org/10.1101/2022.02.19.481107
Autor:
Martin A. Rossotti, Henk van Faassen, Anh T. Tran, Joey Sheff, Jagdeep K. Sandhu, Diana Duque, Melissa Hewitt, Xiaoxue Wen, Jegarubee Bavananthasivam, Saina Beitari, Kevin Matte, Geneviève Laroche, Patrick M. Giguère, Christian Gervais, Matthew Stuible, Julie Guimond, Sylvie Perret, Greg Hussack, Marc-André Langlois, Yves Durocher, Jamshid Tanha
Publikováno v:
Communications biology. 5(1)
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2. Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern (VoCs) and feasibility to engineer modular, multimeric designs, make these
Autor:
Michaeline McGuinty, Geneviève Laroche, Yannick Galipeau, Angela M. Crawley, Erika Marion, Ronald A. Booth, Matthew Greig, Patrick M. Giguère, Marc-André Langlois, Steffany A. L. Bennett, Miroslava Cuperlovic-Culf, Yves Durocher, Curtis Cooper, Vinayakumar Siragam
Publikováno v:
EBioMedicine, Vol 74, Iss, Pp 103700-(2021)
EBioMedicine
EBioMedicine
BackgroundAntibodies raised against human seasonal coronaviruses (sCoVs), which are responsible for the common cold, are known to cross-react with SARS-CoV-2 antigens. This prompts questions about their protective role against SARS-CoV-2 infections a
Autor:
Mehdi Benlarbi, Geneviève Laroche, Corby Fink, Kathy Fu, Rory P. Mulloy, Alexandra Phan, Ardeshir Ariana, Corina M. Stewart, Jérémie Prévost, Guillaume Beaudoin-Bussières, Redaet Daniel, Yuxia Bo, Omar El Ferri, Julien Yockell-Lelièvre, William L. Stanford, Patrick M. Giguère, Samira Mubareka, Andrés Finzi, Gregory A. Dekaban, Jimmy D. Dikeakos, Marceline Côté
Publikováno v:
iScience. 25:105316
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (S) binds to angiotensin-converting enzyme 2 (ACE2) to mediate membrane fusion via two distinct pathways: 1) a surface, serine protease-dependent or 2) an endosomal,
Autor:
Mackenzie J. Thompson, Jaimee A. Domville, Claire H. Edrington, Angelica Venes, Patrick M. Giguère, John E. Baenziger
Publikováno v:
Journal of Biological Chemistry. 298:102104
The outermost lipid-exposed α-helix (M4) in each of the homologous α, β, δ, and γ/ε subunits of the muscle nicotinic acetylcholine receptor (nAChR) has previously been proposed to act as a lipid sensor. However, the mechanism by which this sens