Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Patrick M Boyle"'
Autor:
Yaacoub Chahine, Matthew J Magoon, Bahetihazi Maidu, Juan C del Álamo, Patrick M Boyle, Nazem Akoum
Publikováno v:
Arrhythmia & Electrophysiology Review, Vol 12, Iss , Pp - (2023)
Stroke is a leading cause of death worldwide. With escalating healthcare costs, early non-invasive stroke risk stratification is vital. The current paradigm of stroke risk assessment and mitigation is focused on clinical risk factors and comorbiditie
Externí odkaz:
https://doaj.org/article/bf192ac8694949d09600e31da2476991
Autor:
Ryan P O'Hara, Edem Binka, Adityo Prakosa, Stefan L Zimmerman, Mark J Cartoski, M Roselle Abraham, Dai-Yin Lu, Patrick M Boyle, Natalia A Trayanova
Publikováno v:
eLife, Vol 11 (2022)
Hypertrophic cardiomyopathy (HCM) is associated with risk of sudden cardiac death (SCD) due to ventricular arrhythmias (VAs) arising from the proliferation of fibrosis in the heart. Current clinical risk stratification criteria inadequately identify
Externí odkaz:
https://doaj.org/article/41a1869802864523a63dd249be178dd7
Autor:
Savannah F Bifulco, Griffin D Scott, Sakher Sarairah, Zeinab Birjandian, Caroline H Roney, Steven A Niederer, Christian Mahnkopf, Peter Kuhnlein, Marcel Mitlacher, David Tirschwell, WT Longstreth, Nazem Akoum, Patrick M Boyle
Publikováno v:
eLife, Vol 10 (2021)
Cardiac magnetic resonance imaging (MRI) has revealed fibrosis in embolic stroke of undetermined source (ESUS) patients comparable to levels seen in atrial fibrillation (AFib). We used computational modeling to understand the absence of arrhythmia in
Externí odkaz:
https://doaj.org/article/7854ec6f2a464ae887709439140fc086
Publikováno v:
Clinical Medicine Insights: Cardiology, Vol 11 (2017)
This Special Collection will gather all studies highlighting recent advances in theoretical and experimental studies of arrhythmia, with a specific focus on research seeking to elucidate links between calcium homeostasis in cardiac cells and organ-sc
Externí odkaz:
https://doaj.org/article/959a67ef4b3047cfb22ac35c2c7ab033
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Under diseased conditions, remodeling of the cardiac tissue properties (passive properties) takes place; these are aspects of electrophysiological behavior that are not associated with active ion transport across cell membranes. Remodeling of the pas
Externí odkaz:
https://doaj.org/article/caecc77337314697b6b6731ed145d1ac
Autor:
Patrick M Boyle, Carolyn J Park, Hermenegild J Arevalo, Edward J Vigmond, Natalia A Trayanova
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86947 (2014)
Organ-scale arrhythmogenic consequences of source-sink mismatch caused by impaired excitability remain unknown, hindering the understanding of pathophysiology in disease states like Brugada syndrome and ischemia.We sought to determine whether sodium
Externí odkaz:
https://doaj.org/article/cd668bb0634041ec807bf22b8bdf0dea
Autor:
Gang Li, Brittany D. Brumback, Lei Huang, David M. Zhang, Tiankai Yin, Catherine E. Lipovsky, Stephanie C. Hicks, Jesus Jimenez, Patrick M. Boyle, Stacey L. Rentschler
Publikováno v:
JACC: Basic to Translational Science. 7:1001-1017
Glycogen synthase kinase 3 (GSK-3) inhibition has emerged as a potential therapeutic target for several diseases, including cancer. However, the role for GSK-3 regulation of human cardiac electrophysiology remains ill-defined. We demonstrate that SB2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce118c424bf89ebef749f059b7d3056
https://doi.org/10.1016/j.jacbts.2022.04.007
https://doi.org/10.1016/j.jacbts.2022.04.007
Autor:
Andrey V. Pikunov, Roman A. Syunyaev, Rheeda Ali, Adityo Prakosa, Patrick M. Boyle, Vanessa Steckmeister, Ingo Kutschka, Eric Rytkin, Niels Voigt, Natalia Trayanova, Igor R. Efimov
Atrial fibrillation (AF) is a progressive disease involving both structural and functional remodeling. To investigate the contribution of cell-scale functional remodeling to AF pathogenesis, we combined personalized 3D anatomical models with patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c797acfc0169d53fb283a846c73319c
https://doi.org/10.1101/2023.05.13.540632
https://doi.org/10.1101/2023.05.13.540632
Autor:
Chelsea E. Gibbs, Silvia Marchianó, Kelly Zhang, Xiulan Yang, Charles E. Murry, Patrick M. Boyle
Publikováno v:
The Journal of Physiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08c026309e42c29586b1a0fab8f293b
https://doi.org/10.1113/jp284244
https://doi.org/10.1113/jp284244
Autor:
Patrick M. Boyle, Sakher Sarairah, Kirsten T. Kwan, Griffin D. Scott, Farzana Mohamedali, Carter A. Anderson, Savannah F. Bifulco, Karen G. Ordovas, Jordan Prutkin, Melissa Robinson, Arun R. Sridhar, Nazem Akoum
Publikováno v:
Journal of cardiovascular electrophysiology.
Late-gadolinium enhancement magnetic resonance (LGE-MRI) imaging is increasingly used in management of atrial fibrillation (AFib) patients. Here, we assess the usefulness of LGE-MRI-based fibrosis quantification to predict arrhythmia recurrence in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f915ea44ce4adb5f8576fae7e6ae9e56
https://pubmed.ncbi.nlm.nih.gov/36571158
https://pubmed.ncbi.nlm.nih.gov/36571158