Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Patrick Losey"'
Autor:
Patrick Losey, Emma Ladds, Maud Laprais, Borna Guevel, Laura Burns, Regis Bordet, Daniel C. Anthony
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/0d7a1266e1144c28b6e7b9b4cc4c5f50
Autor:
Daniel C. Anthony, Patrick Losey, Emma Ladds, Régis Bordet, Maud Laprais, Borna Guevel, Laura Burns
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-1 (2017)
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-1 (2017)
Background Fenofibrate, a PPAR-α activator, has shown promising results as a neuroprotective therapy, with proposed anti-inflammatory and anti-oxidant effects. However, it displays poor blood-brain barrier permeability leading to some ambiguity over
Spinal-cord injury is characterized by primary damage as a direct consequence of mechanical insult, and secondary damage that is partly due to the acute inflammatory response. The extent of any hemorrhage within the injured cord is also known to be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc92c060fc9177d792cc36f60bcc9d1
https://ora.ox.ac.uk/objects/uuid:594dfc8f-c520-4a8b-84e3-4948ab7dd1ac
https://ora.ox.ac.uk/objects/uuid:594dfc8f-c520-4a8b-84e3-4948ab7dd1ac
Autor:
Nico van Rooijen, Mehmet Bilgen, Damineh Morsali, Andrew E. M. Davis, Daniel C. Anthony, Sandra J. Campbell, Shing Law, Imran Zahid, Yanyan Jiang, Patrick Losey
Publikováno v:
Neuropharmacology, 55(5), 780-787. Elsevier Limited
Campbell, S J, Zahid, I, Losey, P, Law, S, Jiang, Y, Bilgen, M, van Rooijen, N, Morsali, D, Davis, A E & Anthony, D C 2008, ' Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord ', Neuropharmacology, vol. 55, no. 5, pp. 780-787 . https://doi.org/10.1016/j.neuropharm.2008.06.074
Campbell, S J, Zahid, I, Losey, P, Law, S, Jiang, Y, Bilgen, M, van Rooijen, N, Morsali, D, Davis, A E & Anthony, D C 2008, ' Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord ', Neuropharmacology, vol. 55, no. 5, pp. 780-787 . https://doi.org/10.1016/j.neuropharm.2008.06.074
The CNS inflammatory response is regulated by hepatic chemokine synthesis, which promotes leukocytosis and facilitates leukocyte recruitment to the site of injury. To understand the role of the individual cell populations in the liver during the hepa
Autor:
Daniel C. Anthony, Régis Bordet, Borna Geuvel, Patrick Losey, Emma Ladds, Laura Burns, Maud Laprais
Publikováno v:
Journal of Neuroinflammation. 12
Fenofibrate, a PPAR-α activator, has shown promising results as a neuroprotective therapy, with proposed anti-inflammatory and anti-oxidant effects. However, it displays poor blood-brain barrier permeability leading to some ambiguity over its mechan
Autor:
Patrick Losey, Daniel C. Anthony
Publikováno v:
Neural Regeneration Research
The deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized, and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly associated with a poorer neurologica
Publikováno v:
Neuropharmacology. 79
We examined the effect of fingolimod (0.1 and 0.3 mg/kg/day orally) on blood–brain barrier (BBB) function, demyelination and leukocyte recruitment at different stages of the focal delayed-type hypersensitivity (DTH) multiple sclerosis model in Lewi
Autor:
Kate Lykke Lambertsen, Daniel C. Anthony, Ian L. Sargent, Chris Gardiner, Yvonne Couch, Patrick Losey, Matthew C. Evans
Publikováno v:
Couch, Y, Evans, M C, Gardiner, C, Sargent, I, Losey, P, Lambertsen, K L & Anthony, D C 2014, ' Brain-derived microvesicles confer sickness behaviours by switching on the acute phase response in the liver ', Journal of Neuroimmunology, vol. 275, no. 1-2, pp. 57 . https://doi.org/10.1016/j.jneuroim.2014.08.150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e0882e2e9ff5e57817e3d0a2b25746
https://portal.findresearcher.sdu.dk/da/publications/6532677d-e188-4e2e-b837-9626ef05c657
https://portal.findresearcher.sdu.dk/da/publications/6532677d-e188-4e2e-b837-9626ef05c657
Publikováno v:
Brain, behavior, and immunity. 26(4)
The idea that the brain is immunologically privileged and displays an atypical leukocyte recruitment profile following injury has influenced our ideas about how signals might be carried between brain and the periphery. For many, this has encouraged a
Publikováno v:
Neuropathology and applied neurobiology. 33(1)
Epidemiological evidence indicates that the severity of many human neuropathologies is often age-related, and this also appears true in rodent models of human disease. In this study, we examined the inflammatory response within the brain to the arche