Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Patrick Larpent"'
Autor:
Arnau Carné-Sánchez, Gavin A. Craig, Patrick Larpent, Takashi Hirose, Masakazu Higuchi, Susumu Kitagawa, Kenji Matsuda, Kenji Urayama, Shuhei Furukawa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Porosity in metal–organic materials typically relies on highly ordered crystalline networks, which hinders material processing and morphological control. Here, the authors use metal–organic polyhedra as porous monomers in supramolecular polymeriz
Externí odkaz:
https://doaj.org/article/4967dda1a1874e4db81e40a9e8d53d19
Autor:
Lorenzo Codan, Jochen Schoell, Patrick Larpent, Justin A. Newman, Luca Iuzzolino, Melissa Tan, Alfred Y. Lee
Publikováno v:
Crystal Growth & Design. 21:4207-4219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0817ba6f046917ab95156c6314aeb5
https://doi.org/10.1021/acs.cgd.1c00469
https://doi.org/10.1021/acs.cgd.1c00469
Autor:
Anne E. Mohan, Siqing Song, Hsieh Yao D. Chang, Si-Wei Zhang, Patrick Larpent, Wenjun Liu, Michael DiBenedetto, Eric B. Sirota, Michael J. Di Maso, Richard Desmond, Kevin M. Maloney, Ivan H. Lee, Alfred Y. Lee, Guy R. Humphrey, Embarek Alwedi, Hong Ren
Publikováno v:
Organic Process Research & Development. 24:2498-2504
The development of a sustainable commercial salt formation process for gefapixant citrate (MK-7264), an investigational new P2X3 antagonist for the treatment of chronic cough, is described. Due to ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facd961a62dfed3fd28d482411a9320b
https://doi.org/10.1021/acs.oprd.0c00260
https://doi.org/10.1021/acs.oprd.0c00260
Autor:
Michael J. Di Maso, Si-Wei Zhang, Wenjun Liu, Embarek Alwedi, Alfred Y. Lee, Richard Desmond, Hong Ren, Sumei Ren, Karthik Narsimhan, Alexei Kalinin, Kevin M. Maloney, Patrick Larpent
Publikováno v:
Organic Process Research & Development. 24:2491-2497
A scalable two-pot sulfonamidation through the process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c2a51ca82231c4c49ef265b0a9a9741
https://doi.org/10.1021/acs.oprd.0c00247
https://doi.org/10.1021/acs.oprd.0c00247
Autor:
Jinchu Liu, Patrick Larpent, Kallol Basu, Dan Lehnherr, Kevin M. Maloney, Feng Peng, Ryan D. Cohen, Rebecca A. Arvary, Si-Wei Zhang, Nicholas J. Rogus, Michael J. Di Maso, Gary E. Martin, Francisco J. Guzman, Richard Desmond, Hong Ren, Yu-hong Lam, John Y. L. Chung, Zachary E. X. Dance, Michael A. Zompa
Publikováno v:
Organic Process Research & Development. 24:2462-2477
The development of a safe, robust, and efficient manufacturing route for the synthesis of diaminopyrimidine 1, a key intermediate to gefapixant citrate (MK-7264), is described. A full mechanistic u...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac8ade59139d6a18d85322e69f0e2ba
https://doi.org/10.1021/acs.oprd.0c00246
https://doi.org/10.1021/acs.oprd.0c00246
Autor:
Eric B. Sirota, Karthik Narsimhan, Feng Peng, Mark Weisel, Alfred Y. Lee, Rebecca A. Arvary, Claire Lee, Daniel Bishara, Kevin M. Maloney, Andrew Brunskill, François Lévesque, Patrick Larpent, Michael Whittington, John R. Naber, Guy R. Humphrey, Dan Lehnherr, Si-Wei Zhang
Publikováno v:
Organic Process Research & Development. 24:2453-2461
Various synthetic routes to 2-isopropyl-4-methoxyphenol 3, the phenol core of Gefapixant citrate (MK-7264), are described, which provide better alternatives to the initial four-step supply route. T...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1151aa0b8950e409e75134288d2f80
https://doi.org/10.1021/acs.oprd.0c00241
https://doi.org/10.1021/acs.oprd.0c00241
Autor:
Alexandre Legrand, Hinano Urabe, Mickaele Bonneau, Gavin A. Craig, Shuhei Furukawa, Shinpei Kusaka, Patrick Larpent
Structural deformation in response to gas sorption is rarely observed for porous molecular solids, when compared to porous framework materials. Here, we describe the effect of chemical modification on the exterior of lantern-type metal-organic cages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd67f9b83b9c0366f3b5199380689af
https://doi.org/10.26434/chemrxiv.11798763
https://doi.org/10.26434/chemrxiv.11798763
Autor:
Susumu Kitagawa, Shinpei Kusaka, Gavin A. Craig, Ryotaro Matsuda, Shuhei Furukawa, Patrick Larpent
Publikováno v:
Chemical Science. 9:6463-6469
Gate-opening gas sorption is known for metal–organic frameworks, and is associated with structural flexibility and advantageous properties for sensing and gas uptake. Here, we show that gate-opening is also possible for metal–organic polyhedra (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3e95436458915c41cd4dc776ebf45b
https://doi.org/10.1039/c8sc02263a
https://doi.org/10.1039/c8sc02263a
Publikováno v:
CrystEngComm
CrystEngComm, Royal Society of Chemistry, 2019, 21 (15), pp.2534-2540. ⟨10.1039/c9ce00113a⟩
CrystEngComm, Royal Society of Chemistry, 2019, 21 (15), pp.2534-2540. ⟨10.1039/c9ce00113a⟩
International audience; Upon combining enantiomerically pure chiral organic tectons with cadmium nitrate, homochiral 1D and 2D coordination networks are obtained in the crystalline phase. The dimensionality of the latter as well as their packing in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d8795de3a932182549c0e5546ebde7
https://hal.archives-ouvertes.fr/hal-03011582
https://hal.archives-ouvertes.fr/hal-03011582
Publikováno v:
Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2019, 55 (1), pp.91-94. ⟨10.1039/c8cc08877b⟩
Chemical Communications, Royal Society of Chemistry, 2019, 55 (1), pp.91-94. ⟨10.1039/c8cc08877b⟩
International audience; An achiral organic tecton bearing four coordinating sites of the pyridyl type leads to the formation of iso-structural 3D helical coordination polymers when combined with Co(SCN) 2 and Fe(SCN) 2 achiral neutral complexes. Thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3351f2d1a987fc184157642201790c
https://hal.archives-ouvertes.fr/hal-03011780
https://hal.archives-ouvertes.fr/hal-03011780