Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Patrick Lajoie"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 1 (2022)
AbstractGene expression undergoes considerable changes during the aging process. The mechanisms regulating the transcriptional response to cellular aging remain poorly understood. Here, we employ the budding yeast Saccharomyces cerevisiaeTRA1tra1Q3tr
Externí odkaz:
https://doaj.org/article/7bbdcc64cc70437e8f016a06385cb83c
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100182- (2020)
Summary: We present a detailed protocol that describes the evaluation of the growth and survival of yeast cells by quantitatively analyzing spotting assays. This simple method reproducibly detects and quantifies subtle differences in growth by measur
Externí odkaz:
https://doaj.org/article/e524cecdec0946538dd54a9e32337c08
Autor:
Sarah R. Chadwick, Patrick Lajoie
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Multiple factors lead to proteostatic perturbations, often resulting in the aberrant accumulation of toxic misfolded proteins. Cells, from yeast to humans, can respond to sudden accumulation of secretory proteins within the endoplasmic reticulum (ER)
Externí odkaz:
https://doaj.org/article/6204122cd6e84ce2906adb30379914a8
Publikováno v:
F1000Research, Vol 7 (2018)
Development of fluorescent proteins (FPs) enabled researchers to visualize protein localization and trafficking in living cells and organisms. The extended palette of available FPs allows simultaneous detection of multiple fluorescent fusion proteins
Externí odkaz:
https://doaj.org/article/d66632c4e07448a2863908f089423e16
Autor:
Patrick Lajoie, Erik Lee Snapp
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15245 (2010)
Aggregation and cytotoxicity of mutant proteins containing an expanded number of polyglutamine (polyQ) repeats is a hallmark of several diseases, including Huntington's disease (HD). Within cells, mutant Huntingtin (mHtt) and other polyglutamine expa
Externí odkaz:
https://doaj.org/article/f83801bf85a146a3ba991e54dfc69490
Autor:
Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie, Christopher G Proud, Ivan R Nabi, Michel Roberge
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7124 (2009)
BACKGROUND:Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion. A
Externí odkaz:
https://doaj.org/article/647f3f277aad48c4b8c4c845abe65350
Autor:
Grace H. Kim, Michelle Agyare-Tabbi, Viola Halder, Christopher J. Brandl, Matthew D. Berg, Deeva Uthayakumar, Julie Genereaux, Yuwei Jiang, Rebecca S. Shapiro, Iqra Razzaq, Patrick Lajoie
Publikováno v:
Genetics
Candida albicans is the most common cause of death from fungal infections. The emergence of resistant strains reducing the efficacy of first-line therapy with echinocandins, such as caspofungin calls for the identification of alternative therapeutic
Autor:
Martin L. Duennwald, Sarah R. Chadwick, Patrick Lajoie, Parnian Etedali-Zadeh, Julie Genereaux, Elena N. Fazio
Publikováno v:
Current Genetics. 66:263-277
Progressive impairment of proteostasis and accumulation of toxic misfolded proteins are associated with the cellular aging process. Here, we employed chronologically aged yeast cells to investigate how activation of the unfolded protein response (UPR
Autor:
Yuwei Jiang, Rebecca S. Shapiro, Patrick Lajoie, Julie Genereaux, Christopher J. Brandl, Matthew D. Berg, Iqra Razzaq, Grace H. Kim, Deeva Uthayakumar
Candida albicans is the most common cause of death from fungal infections. Emergence of resistant strains reducing the efficacy of first line therapy with echinocandins such as caspofungin calls for the identification of alternative therapeutic strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08bb0f28d90d8ba11cc9fa49a80fdc6c
https://doi.org/10.1101/2021.03.17.435915
https://doi.org/10.1101/2021.03.17.435915
Autor:
Mariyan J. Jeyarajah, Hiroaki Okae, Gargi Jaju Bhattad, Takahiro Arima, Megan McGill, Nathalie G. Bérubé, Vanessa Dumeaux, Stephen J. Renaud, Patrick Lajoie
Publikováno v:
Paediatrics Publications
Cell Death and Disease, Vol 11, Iss 5, Pp 1-17 (2020)
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 5, Pp 1-17 (2020)
Cell Death & Disease
Cell fusion occurs when several cells combine to form a multinuclear aggregate (syncytium). In human placenta, a syncytialized trophoblast (syncytiotrophoblast) layer forms the primary interface between maternal and fetal tissue, facilitates nutrient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db83d89315c9cdcdf6be7538ee593c58
https://ir.lib.uwo.ca/paedpub/560
https://ir.lib.uwo.ca/paedpub/560