Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Patrick L. Ahl"'
Publikováno v:
The Protein Journal. 39:318-327
The temperature-dependent secondary structure of two monoclonal IgG antibodies, anti-IGF1R and anti-TSLP, were examined by transmission mode Fourier Transform Infrared (FTIR) spectroscopy. Anti-IGF1R and anti-TSLP are IgG monoclonal antibodies (mAbs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::092fb0096a7c8b0a3e89f32d801babc9
https://doi.org/10.1007/s10930-020-09907-y
https://doi.org/10.1007/s10930-020-09907-y
Autor:
William J. Smith, Patrick L. Ahl, Bei Wang, Melissa Hamm, Richard R. Rustandi, Michael A. Winters, Jeffrey T. Blue
Publikováno v:
Vaccine. 40(31)
The covalent attachment of a bacterial-derived capsular polysaccharide to protein is of critical importance in transforming the polysaccharide from an antigen with limited immunogenicity in infants and older adults to an antigen that can prevent pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b22c7534d6f2f34a21e8eefb7342aa
https://pubmed.ncbi.nlm.nih.gov/35688729
https://pubmed.ncbi.nlm.nih.gov/35688729
Autor:
Elizabeth Thoryk, David S. Thiriot, Sayda Elbashir, Jeffrey G. Smith, Nicole L Sullivan, Christine A. Shaw, Morgan A. Monslow, Kalpit A. Vora, Nithya Thambi, Daria J. Hazuda, Cook James C, Patrick L. Ahl, Elise Miller, Michael P. Citron, Scott Cosmi
Publikováno v:
Vaccine. 38(36)
Shingles is a painful, blistering rash caused by reactivation of latent varicella-zoster virus (VZV) and most frequently occurs in elderly and immunocompromised individuals. Currently, two approved vaccines for the prevention of shingles are on the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1bedcc5881ed1417625c9c9757c852
https://pubmed.ncbi.nlm.nih.gov/32703745
https://pubmed.ncbi.nlm.nih.gov/32703745
Autor:
Sheng-Ching Wang, Ramesh Chintala, Christopher D. Mensch, Jeffrey T. Blue, William J. Smith, Marc D. Wenger, Patrick L. Ahl
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 72:149-162
Aluminum containing adjuvants have been widely used in vaccine formulations to safely and effectively potentiate the immune response. The examination of the extent of antigen adsorption to aluminum adjuvant is always evaluated during the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af080fbefef5e83887940fcec064b74
https://doi.org/10.5731/pdajpst.2017.008250
https://doi.org/10.5731/pdajpst.2017.008250
Autor:
Christopher D. Mensch, William J. Smith, Ryann Russell, Craig T. Przysiecki, Heidi Joanne Pixley, Jeffrey T. Blue, Binghua Hu, Lance Dieter, Mike Kosinski, Lan Zhang, Patrick L. Ahl
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3046-3056
Vaccine drug product thermal stability often depends on formulation input factors and how they interact. Scientific understanding and professional experience typically allows vaccine formulators to accurately predict the thermal stability output base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8adb1f64c50d9daef68afc891bd091d
https://doi.org/10.1016/j.xphs.2016.06.014
https://doi.org/10.1016/j.xphs.2016.06.014
Publikováno v:
Pharmaceutical Research. 35
The purpose was to evaluate DSF for high throughput screening of protein thermal stability (unfolding/ aggregation) across a wide range of formulations. Particular focus was exploring PROTEOSTAT® – a commercially available fluorescent rotor dye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1887b58ef08c48668306ce3287c75773
https://doi.org/10.1007/s11095-018-2361-1
https://doi.org/10.1007/s11095-018-2361-1
Autor:
Li Shi, Bei Wang, Patrick L. Ahl, Robert D. Sitrin, Cook James C, Su Wang, Timothy W. Tobery, Jon H. Heinrichs, Jayme L. Cannon, Henryck Mach, Michael J. Caulfield
Publikováno v:
Human Vaccines. 3:139-145
Aluminum adjuvants are commonly used in prophylactic vaccines to enhance antigen immunogenicity through induction of high-titer antibody responses. Three major forms of aluminum adjuvants with substantially different physical and chemical properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03877281709a55abf9d02f07cce8d7f
https://doi.org/10.4161/hv.3.4.4309
https://doi.org/10.4161/hv.3.4.4309
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1616:184-195
We present results on using cooperative interactions to shield liposomes by incorporating multiple hydrophobic anchoring sites on polyethylene glycol (PEG) polymers. The hydrophobically-modified PEGs (HMPEGs) are comb-graft polymers with strictly alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7855a6daebeacc6becc4e3d892b64e51
https://doi.org/10.1016/j.bbamem.2003.08.007
https://doi.org/10.1016/j.bbamem.2003.08.007
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1419:111-126
The specific activation of liposomes for delivery has been explored by enzyme mediated cleavage of a peptide substrate covalently conjugated to a fusogenic lipid. We have previously shown an elastase sensitive peptide conjugated to 1,2-dioleoyl-sn-gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbf2cfe920d886c592bb6dca94819d1
https://doi.org/10.1016/s0005-2736(98)00256-9
https://doi.org/10.1016/s0005-2736(98)00256-9
Autor:
Patrick L. Ahl, Walter Perkins, Theodore F. Taraschi, Andrew S. Janoff, Lu Chen, Sharma R. Minchey, Lawrence T. Boni
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1195:237-244
Previously we demonstrated that fused phospholipid sheets can be formed from small unilamellar vesicles (SUVs) comprised of saturated symmetric chain lipids by exposing them to concentrations of ethanol sufficient to cause bilayer interdigitation (Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1293dae9d5e7b3d3d9274332f44a58
https://doi.org/10.1016/0005-2736(94)90262-3
https://doi.org/10.1016/0005-2736(94)90262-3