Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Patrick Lüningschrör"'
Publikováno v:
Cells, Vol 13, Iss 17, p 1498 (2024)
ER-phagy is a specialized form of autophagy, defined by the lysosomal degradation of ER subdomains. ER-phagy has been implicated in relieving the ER from misfolded proteins during ER stress upon activation of the unfolded protein response (UPR). Here
Externí odkaz:
https://doaj.org/article/cb7ec2b923654ac8929347cf8d0e3028
Autor:
Bita Massih, Alexander Veh, Maren Schenke, Simon Mungwa, Bettina Seeger, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Peter Reinhardt, Jared Sterneckert, Andreas Hermann, Michael Sendtner, Patrick Lüningschrör
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The signals that coordinate and control movement in vertebrates are transmitted from motoneurons (MNs) to their target muscle cells at neuromuscular junctions (NMJs). Human NMJs display unique structural and physiological features, which make them vu
Externí odkaz:
https://doaj.org/article/3abe4a86364943e08d4a264b7f13ba1a
Autor:
Maurilyn Ayon-Olivas, Daniel Wolf, Thomas Andreska, Noelia Granado, Patrick Lüningschrör, Chi Wang Ip, Rosario Moratalla, Michael Sendtner
Publikováno v:
Biology, Vol 12, Iss 10, p 1360 (2023)
Motor dysfunction in Parkinson’s disease (PD) is closely linked to the dopaminergic depletion of striatal neurons and altered synaptic plasticity at corticostriatal synapses. Dopamine receptor D1 (DRD1) stimulation is a crucial step in the formatio
Externí odkaz:
https://doaj.org/article/fafaa12383894617a2a2c0a0743feb34
Autor:
Michael Briese, Lena Saal-Bauernschubert, Patrick Lüningschrör, Mehri Moradi, Benjamin Dombert, Verena Surrey, Silke Appenzeller, Chunchu Deng, Sibylle Jablonka, Michael Sendtner
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis and other neurodegenerative disorders. The loss of TDP-43 function that is associated with these inclusions affects pos
Externí odkaz:
https://doaj.org/article/39699197e2724b54abe2b580b3a66d45
Autor:
Patrick Lüningschrör, Carsten Slotta, Peter Heimann, Michael Briese, Ulrich M. Weikert, Bita Massih, Silke Appenzeller, Michael Sendtner, Christian Kaltschmidt, Barbara Kaltschmidt
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Inflammation and dysregulation of the immune system are hallmarks of several neurodegenerative diseases. An activated immune response is considered to be the cause of myelin breakdown in demyelinating disorders. In the peripheral nervous system (PNS)
Externí odkaz:
https://doaj.org/article/e3f3ff6a74f04927968c9a252e19b941
Autor:
Patrick Lüningschrör, Georg Werner, Stijn Stroobants, Soichiro Kakuta, Benjamin Dombert, Daniela Sinske, Renate Wanner, Renate Lüllmann-Rauch, Benedikt Wefers, Wolfgang Wurst, Rudi D’Hooge, Yasuo Uchiyama, Michael Sendtner, Christian Haass, Paul Saftig, Bernd Knöll, Anja Capell, Markus Damme
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3506-3519.e6 (2020)
Summary: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiol
Externí odkaz:
https://doaj.org/article/6a9f42b14fca4fb8a5526634d9334b2c
Autor:
Patrick Lüningschrör, Beyenech Binotti, Benjamin Dombert, Peter Heimann, Angel Perez-Lara, Carsten Slotta, Nadine Thau-Habermann, Cora R. von Collenberg, Franziska Karl, Markus Damme, Arie Horowitz, Isabelle Maystadt, Annette Füchtbauer, Ernst-Martin Füchtbauer, Sibylle Jablonka, Robert Blum, Nurcan Üçeyler, Susanne Petri, Barbara Kaltschmidt, Reinhard Jahn, Christian Kaltschmidt, Michael Sendtner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Accumulating evidence suggests that disruption of autophagy is associated with neurodegeneration. Here the authors show that Plekhg5 acts as a GEF for Rab26, a small GTPase that promotes the autophagy of synaptic vesicles in neurons; mice lacking Ple
Externí odkaz:
https://doaj.org/article/ba7baaeefffb431d9f931d09c46a1a22
Autor:
Benjamin Dombert, Stefanie Balk, Patrick Lüningschrör, Mehri Moradi, Rajeeve Sivadasan, Lena Saal-Bauernschubert, Sibylle Jablonka
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Spontaneous Ca2+ transients and actin dynamics in primary motoneurons correspond to cellular differentiation such as axon elongation and growth cone formation. Brain-derived neurotrophic factor (BDNF) and its receptor trkB support both motoneuron sur
Externí odkaz:
https://doaj.org/article/d4aa35e211914bf682ace641539e1665
Autor:
Yvonne Imielski, Jens C Schwamborn, Patrick Lüningschrör, Peter Heimann, Magdalena Holzberg, Hendrikje Werner, Oliver Leske, Andreas W Püschel, Sylvie Memet, Rolf Heumann, Alain Israel, Christian Kaltschmidt, Barbara Kaltschmidt
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30838 (2012)
Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis. Here we show that genetic ablation of NF-κB resulted in severe def
Externí odkaz:
https://doaj.org/article/53857d67d18447c4942306c5225d5d8d
Autor:
Francesca De Lorenzo, Patrick Lüningschrör, Jinhan Nam, Liam Beckett, Federica Pilotto, Emilia Galli, Päivi Lindholm, Cora Rüdt von Collenberg, Simon Tii Mungwa, Sibylle Jablonka, Julia Kauder, Nadine Thau-Habermann, Susanne Petri, Dan Lindholm, Smita Saxena, Michael Sendtner, Mart Saarma, Merja H Voutilainen
Publikováno v:
De Lorenzo, Francesca; Lüningschrör, Patrick; Nam, Jinhan; Beckett, Liam; Pilotto, Federica; Galli, Emilia; Lindholm, Päivi; Rüdt von Collenberg, Cora; Tii Mungwa, Simon; Jablonka, Sibylle; Kauder, Julia; Thau-Habermann, Nadine; Petri, Susanne; Lindholm, Dan; Saxena, Smita; Sendtner, Michael; Saarma, Mart; Voutilainen, Merja H (2023). CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress. (In Press). Brain : a journal of neurology Oxford University Press 10.1093/brain/awad087
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects motor neurons in the spinal cord, brainstem and motor cortex, leading to paralysis and eventually to death within 3–5 years of symptom onset. To date, no cure or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07df6b4ff858dd1d31c2e6eea8fb8b83
https://boris.unibe.ch/180302/1/awad087.pdf
https://boris.unibe.ch/180302/1/awad087.pdf