Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Patrick L, Wintrode"'
Autor:
Erik H. Klontz, Chao Li, Kyle Kihn, James K. Fields, Dorothy Beckett, Greg A. Snyder, Patrick L. Wintrode, Daniel Deredge, Lai-Xi Wang, Eric J. Sundberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
AlfC transfucosidase is used to modulate fucosylation of glycans decorating monoclonal antibodies. Herein, structural and biophysical characterization reveals the enzymatic mechanism of AlfC and a blueprint for the design of AlfC mutants with novel s
Externí odkaz:
https://doaj.org/article/9a30450512214f37b47bbcf6f541a3c3
Autor:
Erik H. Klontz, Beatriz Trastoy, Daniel Deredge, James K. Fields, Chao Li, Jared Orwenyo, Alberto Marina, Robert Beadenkopf, Sebastian Günther, Jair Flores, Patrick L. Wintrode, Lai-Xi Wang, Marcelo E. Guerin, Eric J. Sundberg
Publikováno v:
ACS Central Science, Vol 5, Iss 3, Pp 524-538 (2019)
Externí odkaz:
https://doaj.org/article/004711398bcc42978684ed40020eff2d
Autor:
Haarin Chun, James H. Kurasawa, Philip Olivares, Ekaterina S. Marakasova, Svetlana A. Shestopal, Gabriela U. Hassink, Elena Karnaukhova, Mary Migliorini, Juliet O. Obi, Ally K. Smith, Patrick L. Wintrode, Prasannavenkatesh Durai, Keunwan Park, Daniel Deredge, Dudley K. Strickland, Andrey G. Sarafanov
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2255-2269
Deficiency in blood coagulation factor VIII (FVIII) results in life-threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve disease treatment, FVIII has been modified to increase its plasma half-life, which requires u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe192fa0a6be1b8e8c0b22fd5c2adbb
https://doi.org/10.1111/jth.15817
https://doi.org/10.1111/jth.15817
Autor:
Upneet Kaur, Kyle C. Kihn, Haiping Ke, Weiwei Kuo, Lila M. Gierasch, Daniel N. Hebert, Patrick L. Wintrode, Daniel Deredge, Anne Gershenson
Many multi-domain proteins including the serpin family of serine protease inhibitors contain non-sequential domains composed of regions that are far apart in sequence. Because proteins are translated vectorially from N-to C-terminus, such domains pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2de98a94a1a2dfc8cfa68e0d48ae20c
https://doi.org/10.1101/2023.04.24.537978
https://doi.org/10.1101/2023.04.24.537978
Autor:
Kyle Kihn, Elisa Marchiori, Giovanni Spagnolli, Alberto Boldrini, Luca Terruzzi, Daniel A. Lawrence, Anne Gershenson, Pietro Faccioli, Patrick L. Wintrode
The serpin plasminogen activator inhibitor 1 (PAI-1) spontaneously undergoes a massive structural change from a metastable, active conformation, with a solvent accessible reactive center loop (RCL), to a stable, inactive or latent conformation in whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c996420d713676b40cb982bcc2e0e28d
https://doi.org/10.1101/2022.07.19.500692
https://doi.org/10.1101/2022.07.19.500692
Autor:
Kyle Kihn, Elisa Marchiori, Giovanni Spagnolli, Alberto Boldrini, Luca Terruzzi, Daniel A. Lawrence, Anne Gershenson, Pietro Faccioli, Patrick L. Wintrode
Publikováno v:
The Journal of biological chemistry.
The serpin plasminogen activator inhibitor 1 (PAI-1) spontaneously undergoes a massive structural change from a metastable, active conformation, with a solvent-accessible reactive center loop (RCL), to a stable, inactive or latent conformation, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f3d1749a6bd22228fdd500ca6419bb
https://pubmed.ncbi.nlm.nih.gov/36444882
https://pubmed.ncbi.nlm.nih.gov/36444882
Autor:
Sandra Postel, Daniel Deredge, Daniel A Bonsor, Xiong Yu, Kay Diederichs, Saskia Helmsing, Aviv Vromen, Assaf Friedler, Michael Hust, Edward H Egelman, Dorothy Beckett, Patrick L Wintrode, Eric J Sundberg
Publikováno v:
eLife, Vol 5 (2016)
Flagella are crucial for bacterial motility and pathogenesis. The flagellar capping protein (FliD) regulates filament assembly by chaperoning and sorting flagellin (FliC) proteins after they traverse the hollow filament and exit the growing flagellum
Externí odkaz:
https://doaj.org/article/bee7c0a8aa6d4f5a84b1d0eee2a39ce4
Publikováno v:
Journal of Biological Chemistry. 295:15-33
Computational simulations of protein folding can be used to interpret experimental folding results, to design new folding experiments, and to test the effects of mutations and small molecules on folding. However, whereas major experimental and comput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f53ac3bfb59b50991340c225f3d0bd
https://doi.org/10.1074/jbc.rev119.006794
https://doi.org/10.1074/jbc.rev119.006794
Autor:
Paul Suhwan Lee, Richard T. Bradshaw, Fabrizio Marinelli, Kyle Kihn, Ally Smith, Patrick L. Wintrode, Daniel J. Deredge, José D. Faraldo-Gómez, Lucy R. Forrest
Publikováno v:
Living J Comput Mol Sci
Hydrogen-deuterium exchange (HDX) is a comprehensive yet detailed probe of protein structure and dynamics and, coupled to mass spectrometry, has become a powerful tool for investigating an increasingly large array of systems. Computer simulations are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12397f0c54e4056c3647f6e909512ec
https://doi.org/10.33011/livecoms.3.1.1521
https://doi.org/10.33011/livecoms.3.1.1521
Autor:
Daniel Deredge, Zhong-Xing Jiang, Yihua Bruce Yu, Margaret E. Smith, Katharine T. Briggs, Yu Li, Marc B. Taraban, Patrick L. Wintrode
Publikováno v:
Magnetic Resonance in Chemistry. 57:861-872
The conformational transition of a fluorinated amphiphilic dendrimer is monitored by the 1 H signal from water, alongside the 19 F signal from the dendrimer. High-field NMR data (chemical shift δ, self-diffusion coefficient D, longitudinal relaxatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f8e509ec8780e389180180cf87326a8
https://doi.org/10.1002/mrc.4849
https://doi.org/10.1002/mrc.4849