Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Patrick L, Mulcrone"'
Autor:
Junping Zhang, Dylan A. Frabutt, Matthew Chrzanowski, Ning Li, Lohra M. Miller, Jiahe Tian, Patrick L. Mulcrone, Anh K. Lam, Benjamin E. Draper, Martin F. Jarrold, Roland W. Herzog, Weidong Xiao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101206- (2024)
Self-complementary AAV vectors (scAAV) use a mutant inverted terminal repeat (mITR) for efficient packaging of complementary stranded DNA, enabling rapid transgene expression. However, inefficient resolution at the mITR leads to the packaging of mono
Externí odkaz:
https://doaj.org/article/ba0fb73ec32b4ab08090643c484cf170
Autor:
Patrick L. Mulcrone, Anh K. Lam, Dylan Frabutt, Junping Zhang, Matthew Chrzanowski, Roland W. Herzog, Weidong Xiao
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Although more adeno-associated virus AAV-based drugs enter the clinic, vector tissue tropism remains an unresolved challenge that limits its full potential despite that the tissue tropism of naturally occurring AAV serotypes can be altered b
Externí odkaz:
https://doaj.org/article/3995dcbcc1cb483fa7902a0c60257d86
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 73-88 (2022)
Gene therapy is a powerful biological tool that is reshaping therapeutic landscapes for several diseases. Researchers are using both non-viral and viral-based gene therapy methods with success in the lab and the clinic. In the cancer biology field, g
Externí odkaz:
https://doaj.org/article/00736ddb79e44d51ad347054e804a84b
Autor:
Anh K. Lam, Junping Zhang, Dylan Frabutt, Patrick L. Mulcrone, Lei Li, Lifan Zeng, Roland W. Herzog, Weidong Xiao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 185-194 (2022)
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With the skyrocketing rate of AAV research and the prevalence of many new engineered capsids being investigated in preclinical and clinical trials, capsid characterizati
Externí odkaz:
https://doaj.org/article/19ab892021054159a919044b17f3e279
Autor:
Junping Zhang, Ping Guo, Xiangping Yu, Dylan A. Frabutt, Anh K. Lam, Patrick L. Mulcrone, Matthew Chrzanowski, Jenni Firrman, Derek Pouchnik, Nianli Sang, Yong Diao, Roland W. Herzog, Weidong Xiao
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 852-861 (2022)
Recombinant adeno-associated virus (rAAV) vectors have been developed for therapeutic treatment of genetic diseases. Current rAAV vectors administered to affected individuals often contain vector DNA-related contaminants. Here we present a thorough m
Externí odkaz:
https://doaj.org/article/c6c9ec66ff5f44fb9ea07ac49a6b0bc3
Autor:
Kazuaki Miyagawa, Hirofumi Tenshin, Patrick L. Mulcrone, Jesus Delgado-Calle, Mark A. Subler, Jolene J. Windle, John M. Chirgwin, G. David Roodman, Noriyoshi Kurihara
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
We previously reported that measles virus nucleocapsid protein (MVNP) expression in osteoclasts (OCLs) of patients with Paget disease (PD) or targeted to the OCL lineage in MVNP-transgenic mice (MVNP mice) increases IGF1 production in osteoclasts (OC
Externí odkaz:
https://doaj.org/article/ca8a54cfa3864041b3e4981930611400
Autor:
Lise Clément-Demange, Patrick L. Mulcrone, Troy Q Tabarestani, Julie A. Sterling, Florent Elefteriou
Publikováno v:
Journal of Bone Oncology, Vol 13, Iss , Pp 1-10 (2018)
Progression and recurrence of breast cancer, as well as reduced survival of patients with breast cancer, are associated with chronic stress, a condition known to impact the hypothalamic-pituitary axis and the autonomic nervous system. Preclinical and
Externí odkaz:
https://doaj.org/article/a03d7be8b45a4678b30c65e39a3361d2
Autor:
Junping Zhang, Matthew Chrzanowski, Dylan A. Frabutt, Anh K. Lam, Patrick L. Mulcrone, Lei Li, Barbara A. Konkle, Carol H. Miao, Weidong Xiao
Publikováno v:
J Med Virol
Recombinant adeno-associated virus (rAAV) vectors carry a cassette of interest retaining only the inverted terminal repeats (ITRs) from the wild-type virus. Conventional rAAV production primarily uses a vector plasmid as well as helper genes essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d146a4b4d1dbc97a99d479b6f261c6
https://pubmed.ncbi.nlm.nih.gov/36571262
https://pubmed.ncbi.nlm.nih.gov/36571262
Autor:
Patrick L. Mulcrone, Junping Zhang, P. Melanie Pride, Anh K. Lam, Dylan A. Frabutt, Susan M. Ball-Kell, Weidong Xiao
Publikováno v:
Advances in Cell and Gene Therapy.
Recombinant AAV (rAAV) gene therapy is being investigated as an effective therapy for several diseases including hemophilia B. Reports of liver tumor development in certain mouse models due to AAV treatment and genomic integration of the rAAV vector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e0d9c6933f4fbd538671b7873adcac
Autor:
Daniela N, Petrusca, Patrick L, Mulcrone, David A, Macar, Ryan T, Bishop, Evgeny, Berdyshev, Attaya, Suvannasankha, Judith L, Anderson, Quanhong, Sun, Philip E, Auron, Deborah L, Galson, G David, Roodman
Publikováno v:
Cancers. 14(3)
Multiple myeloma (MM) remains incurable for most patients due to the emergence of drug resistant clones. Here we report a p53-independent mechanism responsible for Growth Factor Independence-1 (GFI1) support of MM cell survival by its modulation of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60a8b67f5ac6fb49ba39449d8c050897
https://pubmed.ncbi.nlm.nih.gov/35159039
https://pubmed.ncbi.nlm.nih.gov/35159039