Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Patrick L, Collins"'
Autor:
Nidhi Rohatgi, Wei Zou, Yongjia Li, Kevin Cho, Patrick L. Collins, Eric Tycksen, Gaurav Pandey, Carl J. DeSelm, Gary J. Patti, Anwesha Dey, Steven L. Teitelbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Treatment of osteoporosis commonly diminishes osteoclast number which suppresses bone formation thus compromising fracture prevention. Bone formation is not suppressed, however, when bone degradation is reduced by retarding osteoclast functi
Externí odkaz:
https://doaj.org/article/cccf1d8177fb4ec0a2c526ee79cec6f1
Autor:
Kaitlin A. Read, Devin M. Jones, Srijana Pokhrel, Emily D. S. Hales, Aditi Varkey, Jasmine A. Tuazon, Caprice D. Eisele, Omar Abdouni, Abbey Saadey, Melissa R. Leonard, Robert T. Warren, Michael D. Powell, Jeremy M. Boss, Emily A. Hemann, Jacob S. Yount, Gang Xin, Hazem E. Ghoneim, Chan-Wang J. Lio, Aharon G. Freud, Patrick L. Collins, Kenneth J. Oestreich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The regulation and direction of CD4+ T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4+ cytotoxic and T follicular helper lineages.
Externí odkaz:
https://doaj.org/article/db3616878fde4edbb2df4e62fd0817bd
Autor:
Clare K. Cimperman, Mirna Pena, Sohret M. Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, ChenFeng Qi, Daniel Sturdevant, Louis H. Miller, Patrick L. Collins, Susan K. Pierce, Munir Akkaya
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Cerebral malaria (CM), the deadliest complication of Plasmodium infection, is a complex and unpredictable disease. However, our understanding of the host and parasite factors that cause CM is limited. Using a mouse model of CM, experimental
Externí odkaz:
https://doaj.org/article/3261caae55db47f9969e701fac6f0d4d
Autor:
Patrick L. Collins, Caitlin Purman, Sofia I. Porter, Vincent Nganga, Ankita Saini, Katharina E. Hayer, Greer L. Gurewitz, Barry P. Sleckman, Jeffrey J. Bednarski, Craig H. Bassing, Eugene M. Oltz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Formation of γH2Ax serves as a checkpoint for double-strand break (DSB) repair pathways. Here the authors reveal via integrated chromatin analysis that γH2Ax domains are established by chromosomal contacts with the DSB site.
Externí odkaz:
https://doaj.org/article/52e96531818443018246302cc0d348bc
Autor:
Hongming Ma, Wei Qian, Monika Bambouskova, Patrick L. Collins, Sofia I. Porter, Andrea K. Byrum, Rong Zhang, Maxim Artyomov, Eugene M. Oltz, Nima Mosammaparast, Jonathan J. Miner, Michael S. Diamond
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated da
Externí odkaz:
https://doaj.org/article/0f2c9b9750b24e7f848a405e26004f91
Publikováno v:
Annu Rev Immunol
Cell identity and function largely rely on the programming of transcriptomes during development and differentiation. Signature gene expression programs are orchestrated by regulatory circuits consisting of cis-acting promoters and enhancers, which re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b1a04d7a292ef0a0e3795adbfd2abd
https://doi.org/10.1146/annurev-immunol-101320-025949
https://doi.org/10.1146/annurev-immunol-101320-025949
Autor:
Clare K. Cimperman, Mirna Pena, Sohret M. Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, ChenFeng Qi, Daniel Sturdevant, Louis H. Miller, Patrick L Collins, Susan K. Pierce, Munir Akkaya
Cerebral Malaria (CM), the deadliest complication ofPlasmodiuminfection, is a complex and unpredictable disease. However, our understanding of the host and parasite factors that cause CM is limited. Using a mouse model of CM, experimental CM (ECM), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48bc41d815ba2f783e94cf8e4f98409
https://doi.org/10.1101/2022.11.23.517617
https://doi.org/10.1101/2022.11.23.517617
Autor:
Caprice D. Eisele, Courtney J. Riedinger, Jesse J. Kowalski, Bethany L. Mundy-Bosse, Paige M. Porrett, Patrick L. Collins, Casey M. Cosgrove, Aharon G. Freud
Publikováno v:
Cancer Research. 83:1351-1351
Endometrial Cancer (EC) is the most common gynecological malignancy in the United States, with striking heterogeneity of risk factors, molecular identities, and outcomes. Two common subtypes of EC are Type 1, which display endometrioid histology and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adbe52c67359d21eecd438e51774ad0a
https://doi.org/10.1158/1538-7445.am2023-1351
https://doi.org/10.1158/1538-7445.am2023-1351
Autor:
Matthew R Lordo, Thanh T Dinh, Nikolas A Shilo, Ekaterina S Altynova, Erin G. Jeremy, Aditi Varkey, Patrick L Collins, Aharon G Freud, Bethany L Mundy-Bosse
Publikováno v:
Blood. 140:5494-5495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ae28634cf51e25381449652575ea5c3
https://doi.org/10.1182/blood-2022-167732
https://doi.org/10.1182/blood-2022-167732
Autor:
Konstantin Zaitsev, Roman Chernyatchik, Patrick L. Collins, Sviatoslav Sidorov, Mykyta Artomov, Juhi Bagaitkar, Mark J. Daly, Ekaterina Loginicheva, Aleksei Dievskii, Amanda Swain, Eugene M. Oltz, Laura L. Arthur, Denis A. Mogilenko, Marko Jovanovic, Irina Shchukina, German Demidov, Oleg Shpynov, Christina Camell, Alexandra Panteleeva, Monika Bambouskova, Sheila A. Stewart, Maxim N. Artyomov, Sergey Dmitriev, Petr Tsurinov, Vishwa Deep Dixit, Sofia I. Porter, Erica Wolin, Evgeny Kurbatsky
Publikováno v:
Nature aging
The impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad70c31fd7ae30ecc93af6fd883493d4
https://doi.org/10.1038/s43587-020-00002-6
https://doi.org/10.1038/s43587-020-00002-6