Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Patrick Kratschmer"'
Autor:
Srinivasa R. Rao, Alison Howarth, Patrick Kratschmer, Ann E. Snaith, Clarence Yapp, Daniel Ebner, Freddie C. Hamdy, Claire M. Edwards
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Identifying new mechanisms that underlie the complex process of metastasis is vital to combat this fatal step in prostate cancer (PCa) progression. Small non-coding RNAs are emerging as important regulators of tumor cell biology. Here we take an inte
Externí odkaz:
https://doaj.org/article/c186622b7f404a8b9206592704de88ba
Autor:
James J L Hodge, Edgar Buhl, Dimitri M. Kullmann, Simon Lowe, James E.C. Jepson, Patrick Kratschmer, Alan Pittman, Ko-Fan Chen
Publikováno v:
Kratschmer, P, Lowe, S A, Buhl, E, Chen, K-F, Kullmann, D M, Pittman, A, Hodge, J J L & Jepson, J E C 2021, ' Impaired pre-motor circuit activity and movement in a Drosophila model of KCNMA1-linked dyskinesia ', Movement Disorders, vol. 36, no. 5, pp. 1158-1169 . https://doi.org/10.1002/mds.28479
Movement Disorders
Movement Disorders
Background Paroxysmal dyskinesias (PxDs) are characterized by involuntary movements and altered pre‐motor circuit activity. Causative mutations provide a means to understand the molecular basis of PxDs. Yet in many cases, animal models harboring co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9072c0641ebdde5b853ad64ccdc1a978
https://research-information.bris.ac.uk/en/publications/1c8174e6-e6e0-43b6-885f-978b12fc56c1
https://research-information.bris.ac.uk/en/publications/1c8174e6-e6e0-43b6-885f-978b12fc56c1
Autor:
Simon Lowe, James E.C. Jepson, Edgar Buhl, Patrick Kratschmer, James J L Hodge, Dimitri M. Kullmann, Ko-Fan Chen
BackgroundGenetic and in vitro studies have linked a heterozygous gain-of-function mutation (D434G) in the hSlo1 BK (Big potassium) channel to paroxysmal dyskinesia. However, support for this linkage from in vivo models has been lacking.ObjectivesWe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863161291b72ccd630d666b3607fa732
https://doi.org/10.1101/2020.02.20.957571
https://doi.org/10.1101/2020.02.20.957571
Autor:
Srinivasa R. Rao, Alison Howarth, Patrick Kratschmer, Ann E. Snaith, Clarence Yapp, Daniel Ebner, Freddie C. Hamdy, Claire M. Edwards
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, Vol 10 (2020)
Identifying new mechanisms that underlie the complex process of metastasis is vital to combat this fatal step in prostate cancer (PCa) progression. Small non-coding RNAs are emerging as important regulators of tumour cell biology. Here we take an int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341179931bd1b91d11b256b5e5007b89
https://pubmed.ncbi.nlm.nih.gov/32231998
https://pubmed.ncbi.nlm.nih.gov/32231998
Autor:
Claire M. Edwards, Srinivasa R. Rao, James R. Edwards, Patrick Kratschmer, James E.C. Jepson, Sam W. Z. Olechnowicz
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Experimental biological model system outcomes such as altered animal movement capability or behaviour are difficult to quantify manually. Existing automatic movement tracking devices can be expensive and imposing upon the typical environment of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f013e89cb15f78e8933b03bddd3b9df7
https://doi.org/10.1038/s41598-019-48841-7
https://doi.org/10.1038/s41598-019-48841-7
SUMMARYIn the wild, when to go to sleep is a critical decision. Sleep onset is controlled by two processes: the circadian clock, and a homeostat measuring sleep drive [1, 2]. Environmental stimuli must also clearly intersect with the circadian clock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3378d3a2580154c0c7d3b165879b1c3a
Publikováno v:
Current biology : CB. 28(19)
Summary Circadian clocks play conserved roles in gating sleep and wake states throughout the day-night cycle [ 1 , 2 , 3 , 4 , 5 ]. In the fruit fly Drosophila melanogaster, DN1p clock neurons have been reported to play both wake- and sleep-promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5488ad444de3fd873f96c5d24b123f
https://pubmed.ncbi.nlm.nih.gov/30270186
https://pubmed.ncbi.nlm.nih.gov/30270186
Primary dystonia is a hyperkinetic movement disorder linked to altered dopaminergic signaling and synaptic plasticity in regions of the brain involved in motor control. Mutations inHPCA, encoding the neuronal calcium sensor Hippocalcin, are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a8cf670d68e6040fefca441532bba9
Autor:
A. Snaith, A. Haire, Srinivasa R. Rao, Freddie C. Hamdy, D. Ebner, Patrick Kratschmer, A. Howarth, Clarence Yapp, Claire M. Edwards
Publikováno v:
European Urology Supplements. 16:e241-e242
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d6317ecfebc8f4b23d7ab033b7f6a8b
https://doi.org/10.1016/s1569-9056(17)30211-7
https://doi.org/10.1016/s1569-9056(17)30211-7