Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Patrick Kibler"'
Autor:
Benben Song, Kalyani Jambunathan, Patrick Kibler, Aaron N. Endsley, Surendra Kumar Nayak, Amit K. Galande
Publikováno v:
Chemical Biology & Drug Design. 86:1433-1437
Hemopressin is a naturally occurring and therapeutically relevant peptide with applications in hypertension, pain, addiction, and obesity. We had previously demonstrated that hemopressin converts into amyloid-like fibrils under aqueous conditions. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b2272d5a5979eae3e273f58260e806
https://doi.org/10.1111/cbdd.12610
https://doi.org/10.1111/cbdd.12610
Autor:
U. S. Raghavender, Surendra Kumar Nayak, Amit K. Galande, Meghan E Cupp, Patrick Kibler, William J Thomsen, Benben Song
Publikováno v:
Journal of Peptide Science. 19:337-344
With an increasing number of new chemical entities entering clinical studies, and an increasing share of the market, peptides and peptidomimetics constitute one of the most promising classes of therapeutics. The success of synthetic peptides as thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79cb5b3b535bbcb39ad319f45fc253e8
https://doi.org/10.1002/psc.2502
https://doi.org/10.1002/psc.2502
Publikováno v:
Biomacromolecules. 13:579-583
The nonapeptide hemopressin, which is derived from the α chain of hemoglobin, has been reported to exhibit inverse agonist activity against the CB1 receptor. Administration of this peptide in animal models led to decreased food intake and elicited h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d611b2d1ae760d38ecd4b459c66a5647
https://doi.org/10.1021/bm201836f
https://doi.org/10.1021/bm201836f
Publikováno v:
Organic Letters. 14:732-735
Serine-Proline (SP) dipeptide motifs have been shown to form unique hydrogen-bonding patterns in protein crystal structures. Peptides were designed to mimic these patterns by forming the 6 + 10 and the 9 + 10 hydrogen-bonded rings. Factors that contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9c1e836a4813d1988c6a23fb995c4e
https://doi.org/10.1021/ol203272k
https://doi.org/10.1021/ol203272k
Publikováno v:
Organic Letters. 13:5878-5881
Aiming to design short linear peptides featuring strong intramolecular hydrogen bonds in water, a series of tetrapeptides based on the sequence Ac-Ala-Pro-Ala-Ala-NH(2) containing all possible combinations of L- and D-amino acids was synthesized. A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e864e84f7cea20674d988666cbcb6e
https://doi.org/10.1021/ol2024983
https://doi.org/10.1021/ol2024983
Autor:
Kalyani Jambunathan, Amit K. Galande, Benben Song, Surendra Kumar Nayak, Amina S Adem, Patrick Kibler, Aaron N. Endsley
Publikováno v:
The FASEB Journal. 28
Hemopressin is a naturally occurring nonapeptide derived from the α-chain of hemoglobin that acts as an inverse agonist for the type-1 cannabinoid (CB1) receptor. Based on its in vivo activity, hem...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5083f44eceae06329f0253e1d6329a76
https://doi.org/10.1096/fasebj.28.1_supplement.1054.2
https://doi.org/10.1096/fasebj.28.1_supplement.1054.2
Autor:
Melissa Works, Annalisa D'Andrea, Amit K. Galande, Mary J. Tanga, Patrick Kibler, Benben Song
Publikováno v:
Protein and peptide letters. 21(5)
Tyrosine kinase inhibitors show great promise as clinical therapies, but small molecule inhibitors that are available in the clinic and under development bind to the adenosine triphosphate binding domain of the kinase, potentially limiting efficacy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e08c2b4980b225c41dec9796379feb
https://pubmed.ncbi.nlm.nih.gov/24304386
https://pubmed.ncbi.nlm.nih.gov/24304386
Publikováno v:
Journal of the American Chemical Society. 132(13)
Using a combination of an aromatic amino acid, a homoserine side chain, and a d-amino acid, a series of linear tetrapeptides were designed that adopt an “Hse turn” in water. The conformation was stabilized by intramolecular hydrogen bonds even in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89a8bce00a1d536c3034be0f639e350
https://pubmed.ncbi.nlm.nih.gov/20232912
https://pubmed.ncbi.nlm.nih.gov/20232912
Publikováno v:
Organic Letters; Nov2011, Vol. 13 Issue 21, p5878-5881, 4p