Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Patrick Kerchan"'
Autor:
Zhiwei Liu, Yang Luo, Samuel Kirimunda, Murielle Verboom, Olusegun O. Onabajo, Mateus H. Gouveia, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Herry Dhudha, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Nathan Cole, Wen Luo, Jia Liu, Michelle Manning, Belynda Hicks, Ludmila Prokunina-Olsson, George Chagaluka, W. Thomas Johnston, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Ann W. Hsing, James E. Mensah, Anthony A. Adjei, Amy Hutchinson, Mary Carrington, Meredith Yeager, Rainer Blasczyk, Stephen J. Chanock, Soumya Raychaudhuri, Sam M. Mbulaiteye
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum. However, whether human leukocyte antigen (HLA) polymo
Externí odkaz:
https://doaj.org/article/9dbb6d4ddc894347a08013feb54d1c14
Autor:
Weiyin Zhou, Anja Fischer, Martin D. Ogwang, Wen Luo, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Mateus H. Gouveia, Nathan Cole, Belynda Hicks, Kristine Jones, Michael Hummel, Mathias Schlesner, George Chagaluka, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Selina Glaser, Helene Kretzmer, Michelle Manning, Amy Hutchinson, Ann W. Hsing, Yao Tettey, Andrew A. Adjei, Stephen J. Chanock, Reiner Siebert, Meredith Yeager, Ludmila Prokunina-Olsson, Mitchell J. Machiela, Sam M. Mbulaiteye
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub
Externí odkaz:
https://doaj.org/article/d757f218f82541a7abe121d8c91e7678
Autor:
Sally Peprah, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Isaac Otim, Ismail D. Legason, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Ruth M. Pfeiffer, Sam M. Mbulaiteye
Publikováno v:
Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background Falciparum and endemic Burkitt lymphoma (eBL) are co-endemic in Africa, but the malaria experience in eBL patients is unknown. A lower prevalence of falciparum has been reported in eBL patients, but those results are anecdotally a
Externí odkaz:
https://doaj.org/article/d9cd604539b046ebade78eff82c45868
Autor:
Hsiao-Mei Liao, Hebing Liu, Pei-Ju Chin, Bingjie Li, Guo-Chiuan Hung, Shien Tsai, Isaac Otim, Ismail D. Legason, Martin D. Ogwang, Steven J. Reynolds, Patrick Kerchan, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Leona W. Ayers, Ruth M. Pfeiffer, Kishor Bhatia, James J. Goedert, Shyh-Ching Lo, Sam M. Mbulaiteye
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Epstein-Barr virus (EBV) is associated with endemic Burkitt lymphoma (eBL), but the contribution of EBV variants is ill-defined. Studies of EBV whole genome sequences (WGS) have identified phylogroups that appear to be distinct for Asian versus non-A
Externí odkaz:
https://doaj.org/article/2a21a29c953b47499ac9f75bebc1c04c
Autor:
Lawrence S. Redmond, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Nestory Masalu, Esther Kawira, Isaac Otim, Ismail D. Legason, Herry Dhudha, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Sam M. Mbulaiteye
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-14 (2020)
Abstract Background Endemic Burkitt lymphoma (eBL) is an aggressive B cell non-Hodgkin lymphoma associated with antigenic stimulation from Plasmodium falciparum malaria. Whether eBL risk is related to malaria parasite density is unknown. To address t
Externí odkaz:
https://doaj.org/article/04009f8923ce4ab6b5c93351efa13f53
Autor:
Rena R. Xian, Tobias Kinyera, Isaac Otim, Joshua N. Sampson, Hadijah Nabalende, Ismail D. Legason, Jennifer Stone, Martin D. Ogwang, Steven J. Reynolds, Patrick Kerchan, Kishor Bhatia, James J. Goedert, Sam M. Mbulaiteye, Richard F. Ambinder
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in regions of equatorial Africa where P. falciparum malaria is holoendemic. The tumor is consistently associated with Epstein-Barr virus (EBV). Screening for EBV DNA in plasma in a hi
Externí odkaz:
https://doaj.org/article/9dfbb1ef324146c49971c60d64c8f4d2
Autor:
Andriy Derkach, Isaac Otim, Ruth M. Pfeiffer, Olusegun O. Onabajo, Ismail D. Legason, Hadijah Nabalende, Martin D. Ogwang, Patrick Kerchan, Ambrose O. Talisuna, Leona W. Ayers, Steven J. Reynolds, Francis Nkrumah, Janet Neequaye, Kishor Bhatia, Thor G. Theander, Ludmila Prokunina-Olsson, Louise Turner, James J. Goedert, Thomas Lavstsen, Sam M. Mbulaiteye
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 358-368 (2019)
Background: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa. We investigated antibody reactivity to several human receptor-binding domains of the Pf erythroc
Externí odkaz:
https://doaj.org/article/86c01784983c474b9b73e9a198f63f6c
Autor:
Marlena Maziarz, Hadijah Nabalende, Isaac Otim, Ismail D. Legason, Tobias Kinyera, Martin D. Ogwang, Ambrose O. Talisuna, Steven J. Reynolds, Patrick Kerchan, Kishor Bhatia, Robert J. Biggar, James J. Goedert, Ruth M. Pfeiffer, Sam M. Mbulaiteye
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-15 (2018)
Abstract Background Plasmodium falciparum malaria is an important cause of morbidity in northern Uganda. This study was undertaken to assess village-, household-, and individual-level risk factors of asymptomatic falciparum malaria in children in 12
Externí odkaz:
https://doaj.org/article/131ff574eb0646faa6901c7a1c16d9a7
Autor:
Ismail D. Legason, Ruth M. Pfeiffer, Krizia-Ivana Udquim, Andrew W. Bergen, Mateus H. Gouveia, Samuel Kirimunda, Isaac Otim, Eric Karlins, Patrick Kerchan, Hadijah Nabalende, Ariunaa Bayanjargal, Benjamin Emmanuel, Paul Kagwa, Ambrose O. Talisuna, Kishor Bhatia, Meredith Yeager, Robert J. Biggar, Leona W. Ayers, Steven J. Reynolds, James J. Goedert, Martin D. Ogwang, Joseph F. Fraumeni, Jr, Ludmila Prokunina-Olsson, Sam M. Mbulaiteye
Publikováno v:
EBioMedicine, Vol 25, Iss C, Pp 58-65 (2017)
Background: Plasmodium falciparum (Pf) malaria infection is suspected to cause endemic Burkitt Lymphoma (eBL), but the evidence remains unsettled. An inverse relationship between sickle cell trait (SCT) and eBL, which supports that between malaria an
Externí odkaz:
https://doaj.org/article/2d035808b01e411893158394fd9cb97c
Autor:
Mateus H Gouveia, Andrew W Bergen, Victor Borda, Kelly Nunes, Thiago P Leal, Martin D Ogwang, Edward D Yeboah, James E Mensah, Tobias Kinyera, Isaac Otim, Hadijah Nabalende, Ismail D Legason, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Patrick Kerchan, Kishor Bhatia, Steven J Reynolds, Richard B Birtwum, Andrew A Adjei, Yao Tettey, Evelyn Tay, Robert Hoover, Ruth M Pfeiffer, Robert J Biggar, James J Goedert, Ludmila Prokunina-Olsson, Michael Dean, Meredith Yeager, M Fernanda Lima-Costa, Ann W Hsing, Sarah A Tishkoff, Stephen J Chanock, Eduardo Tarazona-Santos, Sam M Mbulaiteye
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008027 (2019)
Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria. Interestingly, populations with the highest malaria intensity can be identified by the increased occurrence of endem
Externí odkaz:
https://doaj.org/article/070f691a778f44458d9696507b27c0ce