NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice

Autor: Konstantina Chachlaki, Andrea Messina, Virginia Delli, Valerie Leysen, Csilla Maurnyi, Chieko Huber, Gaëtan Ternier, Katalin Skrapits, Georgios Papadakis, Sonal Shruti, Maria Kapanidou, Xu Cheng, James Acierno, Jesse Rademaker, Sowmyalakshmi Rasika, Richard Quinton, Marek Niedziela, Dagmar L’Allemand, Duarte Pignatelli, Mirjam Dirlewander, Mariarosaria Lang-Muritano, Patrick Kempf, Sophie Catteau-Jonard, Nicolas J. Niederländer, Philippe Ciofi, Manuel Tena-Sempere, John Garthwaite, Laurent Storme, Paul Avan, Erik Hrabovszky, Alan Carleton, Federico Santoni, Paolo Giacobini, Nelly Pitteloud, Vincent Prevot

Publikováno v: Science Translational Medicine
Science Translational Medicine, 2022, 14 (665), pp.eabh2369. ⟨10.1126/scitranslmed.abh2369⟩
Science translational medicine, vol. 14, no. 665, pp. eabh2369

The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal NO synthase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b9ba2a2f53ed6983bfc3208da7475d
https://www.hal.inserm.fr/inserm-03841246

Carbohydrate Intake in the Context of Exercise in People with Type 1 Diabetes

Autor: Patrick Kempf, Sam N. Scott, Lia Bally, Christoph Stettler

Publikováno v: Scott, Sam; Kempf, Patrick; Bally, Lia; Stettler, Christoph (2019). Carbohydrate Intake in the Context of Exercise in People with Type 1 Diabetes. Nutrients, 11(12) Molecular Diversity Preservation International MDPI 10.3390/nu11123017
Nutrients

Although the benefits of regular exercise on cardiovascular risk factors are well established for people with type 1 diabetes (T1D), glycemic control remains a challenge during exercise. Carbohydrate consumption to fuel the exercise bout and/or for h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7c213b3359e73dc9ff3e88e413b8a7

Short‐term effects of dapagliflozin on insulin sensitivity, postprandial glucose excursion and ketogenesis in type 1 diabetes mellitus: A randomized, placebo‐controlled, double blind, cross‐over pilot study

Autor: Christoph Ebenbichler, Patrick Kempf, Thomas R. Pieber, Markus Laimer, Julia K. Mader, Lukas Lunger, Christoph Stettler, Herbert Tilg, Andreas Melmer

Publikováno v: Diabetes, Obesity and Metabolism. 20:2685-2689

We investigated the short-term effects of dapagliflozin as adjunct to insulin on insulin sensitivity, postprandial glucose excursions and ketone body production in type 1 diabetes mellitus (T1DM). A total of seven male patients completed the randomiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8efdf13c6609c1306221dd2e2c0933
https://doi.org/10.1111/dom.13439

Tipps und Tricks zur Behandlung des pankreatopriven Diabetes mellitus

Autor: Christoph Stettler, Patrick Kempf, Markus Laimer

Publikováno v: Therapeutische Umschau. 73:495-499

Zusammenfassung. Verschiedenste Erkrankungen des exokrinen Pankreas können auch Störungen des endokrinen Pankreasanteils verursachen. Der resultierende Diabetes mellitus wird als pankreatopriver (Typ-3c-Diabetes) bezeichnet. Mangel an funktionieren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9b9c4e35c644a940205815e9d4da8e
https://doi.org/10.1024/0040-5930/a000824

Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes

Autor: Luc Tappy, Robin Rosset, Nicola Pasi, Christian Speck, Patrick Kempf, Thomas Zueger, Matthias Wilhelm, Ayse Sila Dokumaci, Christoph Stettler, Lia Bally, Tania Buehler, Hannah Loher, Carlos Ciller, Katrin Feller, Christoph Hans Boesch

Publikováno v: Nutrients; Volume 9; Issue 2; Pages: 164
Nutrients
Nutrients, vol. 9, no. 2, pp. 1-13
Bally, Lia; Kempf, Patrick; Zueger, Thomas; Speck, Christian; Pasi, Nicola; Ciller, Carlos; Feller, Katrin; Loher, Hannah; Rosset, Robin; Wilhelm, Matthias; Boesch, Christoph; Buehler, Tania; Dokumaci, Ayse S.; Tappy, Luc; Stettler, Christoph (2017). Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes. Nutrients, 9(2) Molecular Diversity Preservation International MDPI 10.3390/nu9020164
Europe PubMed Central
Nutrients, 9(2):164
Nutrients, Vol 9, Iss 2, p 164 (2017)

This paper aims to compare the metabolic effects of glucose-fructose co-ingestion (GLUFRU) with glucose alone (GLU) in exercising individuals with type 1 diabetes mellitus. Fifteen male individuals with type 1 diabetes (HbA1c 7.0% ± 0.6% (53 ± 7 mm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7e58b44fb7aa8be769cd660b702ffb