Výsledky vyhledávání - "Patrick Ka Kit Yeung"

Akademický článek

Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Autor: Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian, Sookja Kim Chung

Publikováno v: Microbiome, Vol 10, Iss 1, Pp 1-17 (2022)

Abstract Background Gut microbiota (GM) dysregulation, known as dysbiosis, has been proposed as a crucial driver of obesity associated with “Western” diet (WD) consumption. Gut dysbiosis is associated with increased gut permeability, inflammation

Externí odkaz: https://doaj.org/article/65d94cb3435a4021ae179007539e07c2

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Akademický článek

Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function.

Autor: Man Chi Mak, Ka Man Lam, Ping Kei Chan, Yu Bond Lau, Wai Ho Tang, Patrick Ka Kit Yeung, Ben Chi Bun Ko, Stephen Man Sum Chung, Sookja Kim Chung

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e19186 (2011)

Nuclear factor of activated T cells 5 protein (NFAT5) is thought to be important for cellular adaptation to osmotic stress by regulating the transcription of genes responsible for the synthesis or transport of organic osmolytes. It is also thought to

Externí odkaz: https://doaj.org/article/fa7a0f91eeec4630a9e1b9b988acf99e

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Exchange protein directly activated by cAMP (Epac) 1 plays an essential role in stress-induced exercise capacity by regulating PGC-1α and fatty acid metabolism in skeletal muscle

Autor: Yingxian Chen, Billy C K Chow, Seung Hun Jeong, Hyoung Kyu Kim, Jin Han, Patrick Ka Kit Yeung, Sookja Kim Chung, Wai-Kin So

Publikováno v: Pflügers Archiv - European Journal of Physiology. 472:195-216

Exchange protein directly activated by cAMP (Epac) mediates cAMP-mediated cell signal independent of protein kinase A (PKA). Mice lacking Epac1 displayed metabolic defect suggesting possible functional involvement of skeletal muscle and exercise capa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081a4f01cfa3180d326c8a0b68010cd2
https://doi.org/10.1007/s00424-019-02344-6

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Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation

Autor: Way K.W. Lau, Andrew Chi Kin Law, Rui Feng, Sze-Wah Tam, Patrick Ka Kit Yeung, Sookja K. Chung

Publikováno v: J Biol Chem

Endothelin-1 (ET-1) is a neuroactive peptide produced by neurons, reactive astrocytes, and endothelial cells in the brain. Elevated levels of ET-1 have been detected in the post-mortem brains of individuals with Alzheimer's disease (AD). We have prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29ee6cefb07c8d6129072abc9d60edf
https://doi.org/10.1074/jbc.ra118.005155

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Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood-brain barrier

Autor: Junlei Chang, Fang Zhang, Kai Wang, Ruby L. C. Hoo, Leiluo Geng, Boya Liao, Ling Wei, L Shu, Aimin Xu, Paul M. Vanhoutte, Patrick Ka Kit Yeung, Karen S.L. Lam, Sookja K. Chung

Publikováno v: Liao, B, Geng, L, Zhang, F, Shu, L, Wei, L, Yeung, P K K, Lam, K S L, Chung, S K, Chang, J, Vanhoutte, P M, Xu, A, Wang, K & Hoo, R L C 2020, ' Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood-brain barrier ', European Heart Journal, vol. 41, no. 33, pp. 3169-3180 . https://doi.org/10.1093/eurheartj/ehaa207

Aims Adipocyte fatty acid-binding protein (A-FABP) is an adipokine implicating in various metabolic diseases. Elevated circulating levels of A-FABP correlate positively with poor prognosis in ischaemic stroke (IS) patients. No information is availabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e2a839e9678ee5dcbf7f7836467ffe
https://findresearcher.sdu.dk:8443/ws/files/171459470/ehaa207.pdf

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Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease

Autor: Sookja K. Chung, Angela K. W. Lai, Onyou Hwang, Patrick Ka Kit Yeung, Hyo Jin Son, Xu Zhang, Stephen S.M. Chung

Publikováno v: Neurobiology of Aging. 50:119-133

Fungicide exposure causes degeneration of dopaminergic neurons and contributes to Parkinson's disease (PD). Benomyl inhibits enzymes responsible for detoxifying the reactive dopamine metabolite 3,4-dihydroxyphenylacetaldehyde. Aldose reductase (AR) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f50e7a566b853b521f823b6579e6a5
https://doi.org/10.1016/j.neurobiolaging.2016.11.008

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Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke

Autor: Patrick Ka Kit Yeung, Sookja K. Chung, Ke Zhong, Prince L M Zilundu, Li-Hua Zhou, Xiao Cheng

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-16 (2019)

Background Endothelin-1 (ET-1) is synthesized and upregulated in astrocytes under stroke. We previously demonstrated that transgenic mice over-expressing astrocytic ET-1 (GET-1) displayed more severe neurological deficits characterized by a larger in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb7ccd6730d44d0c0a318dd987b4fba
http://europepmc.org/articles/PMC6858703

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Simple and Rapid Tissue Clearing Method for Three-Dimensional Histology of the Pancreas

Autor: Hang Sheung Wong, Sookja K. Chung, Patrick Ka Kit Yeung, Karen S.L. Lam, Hei Ming Lai, Wu Wutian

Publikováno v: Current protocols in cell biologyLiterature Cited. 77

Previously, high-resolution three-dimensional imaging of a whole and intact pancreas was not possible, since light is scattered when it passes through cell compartments with different refractive indices. CLARITY is one of the tissue clearing techniqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55b9691c4362ee37dfcc506f17485c9
https://pubmed.ncbi.nlm.nih.gov/29227554

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Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy

Autor: Amy C. Y. Lo, Lu Cheng, Stephen S.M. Chung, Patrick Ka Kit Yeung, Sookja K. Chung, Jin Liu

Publikováno v: Science China Life Sciences. 58:521-530

Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are cAMP mediators playing important roles in maintenance of endothelial barrier and neuronal functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3698b7e536c7393fd4d3bf8f10e99146
https://doi.org/10.1007/s11427-015-4860-1

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Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis

Autor: Sookja K. Chung, Patrick Ka Kit Yeung, Shing-Cheong Kwan, Yawei Guo, Philip Wing-Lok Ho, Chung-Wah Siu, Koon-Ho Chan

Publikováno v: Journal of Neuroimmunology. 276:64-70

Multiple sclerosis (MS) is a CNS inflammatory demyelinating disorder. T helper 1 (Th1) and T helper 17 (Th17) cells are important in MS immunopathogenesis. Level of endothelin-1 (ET-1), a potent vasoconstrictor, is increased in sera of MS patients. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c2fcc9b3f3654d9f2e6df0f1f2f3a7
https://doi.org/10.1016/j.jneuroim.2014.08.616

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